Search Results - "Vellenga, Edo"

The multifaceted role of autophagy in cancer and the microenvironment by Folkerts, Hendrik, Hilgendorf, Susan, Vellenga, Edo, Bremer, Edwin, Wiersma, Valerie R.

“…Autophagy is a crucial recycling process that is increasingly being recognized as an important factor in cancer initiation, cancer (stem) cell maintenance as…”
Get full text

Differential redox-regulation and mitochondrial dynamics in normal and leukemic hematopoietic stem cells: A potential window for leukemia therapy by Mattes, Katharina, Vellenga, Edo, Schepers, Hein

“…Leukemia stem cells (LSCs) have low levels of ROS and rely on mitochondrial integrity for their survival. In AML cells, ROS levels and stemness potential are…”
Get full text

Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes by Fenaux, Pierre, Platzbecker, Uwe, Mufti, Ghulam J, Garcia-Manero, Guillermo, Buckstein, Rena, Santini, Valeria, Díez-Campelo, María, Finelli, Carlo, Cazzola, Mario, Ilhan, Osman, Sekeres, Mikkael A, Falantes, José F, Arrizabalaga, Beatriz, Salvi, Flavia, Giai, Valentina, Vyas, Paresh, Bowen, David, Selleslag, Dominik, DeZern, Amy E, Jurcic, Joseph G, Germing, Ulrich, Götze, Katharina S, Quesnel, Bruno, Beyne-Rauzy, Odile, Cluzeau, Thomas, Voso, Maria-Teresa, Mazure, Dominiek, Vellenga, Edo, Greenberg, Peter L, Hellström-Lindberg, Eva, Zeidan, Amer M, Adès, Lionel, Verma, Amit, Savona, Michael R, Laadem, Abderrahmane, Benzohra, Aziz, Zhang, Jennie, Rampersad, Anita, Dunshee, Diana R, Linde, Peter G, Sherman, Matthew L, Komrokji, Rami S, List, Alan F

“…Luspatercept is a fusion protein aimed at binding TGF-β family members and reducing SMAD2 and SMAD3 signaling in patients with myelodysplasia with ring…”
Get full text

Azacitidine maintenance after intensive chemotherapy improves DFS in older AML patients by Huls, Gerwin, Chitu, Dana A., Havelange, Violaine, Jongen-Lavrencic, Mojca, van de Loosdrecht, Arjan A., Biemond, Bart J., Sinnige, Harm, Hodossy, Beata, Graux, Carlos, Kooy, Rien van Marwijk, de Weerdt, Okke, Breems, Dimitri, Klein, Saskia, Kuball, Jürgen, Deeren, Dries, Terpstra, Wim, Vekemans, Marie-Christiane, Ossenkoppele, Gert J., Vellenga, Edo, Löwenberg, Bob

“…The prevention of relapse is the major therapeutic challenge in older patients with acute myeloid leukemia (AML) who have obtained a complete remission (CR) on…”
Get full text

Knockdown of TP53 in ASXL1 negative background rescues apoptotic phenotype of human hematopoietic stem and progenitor cells but without overt malignant transformation by Hilgendorf, Susan, Vellenga, Edo

Get full text

Definition of Iron Deficiency Based on the Gold Standard of Bone Marrow Iron Staining in Heart Failure Patients by Grote Beverborg, Niels, Klip, IJsbrand T, Meijers, Wouter C, Voors, Adriaan A, Vegter, Eline L, van der Wal, Haye H, Swinkels, Dorine W, van Pelt, Joost, Mulder, Andre B, Bulstra, Sjoerd K, Vellenga, Edo, Mariani, Massimo A, de Boer, Rudolf A, van Veldhuisen, Dirk J, van der Meer, Peter

“…The most commonly used definition of iron deficiency (ID; ferritin <100 ng/mL or ferritin 100-300 ng/mL and transferrin saturation [TSAT] <20%) has not been…”
Get full text

Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION) by Kantarjian, Hagop M., Shah, Neil P., Cortes, Jorge E., Baccarani, Michele, Agarwal, Mohan B., Undurraga, María Soledad, Wang, Jianxiang, Kassack Ipiña, Juan Julio, Kim, Dong-Wook, Ogura, Michinori, Pavlovsky, Carolina, Junghanss, Christian, Milone, Jorge H., Nicolini, Franck E., Robak, Tadeusz, Van Droogenbroeck, Jan, Vellenga, Edo, Bradley-Garelik, M. Brigid, Zhu, Chao, Hochhaus, Andreas

“…Dasatinib is a highly potent BCR-ABL inhibitor with established efficacy and safety in imatinib-resistant/-intolerant patients with chronic myeloid leukemia…”
Get full text

Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock by Azkanaz, Maria, Rodríguez López, Aida, de Boer, Bauke, Huiting, Wouter, Angrand, Pierre-Olivier, Vellenga, Edo, Kampinga, Harm H, Bergink, Steven, Martens, Joost Ha, Schuringa, Jan Jacob, van den Boom, Vincent

“…Maintenance of epigenetic modifiers is of utmost importance to preserve the epigenome and consequently appropriate cellular functioning. Here, we analyzed…”
Get full text

The IL1-IL1RAP axis plays an important role in the inflammatory leukemic niche that favors acute myeloid leukemia proliferation over normal hematopoiesis by De Boer, Bauke, Sheveleva, Sofia, Apelt, Katja, Vellenga, Edo, Mulder, André B, Huls, Gerwin, Jacob Schuringa, Jan

“…Upregulation of the plasma membrane receptor IL1RAP in Acute Myeloid Leukemia (AML) has been reported but its role in the context of the leukemic bone marrow…”
Get full text

A Proteomics and Transcriptomics Approach to Identify Leukemic Stem Cell (LSC) Markers by Bonardi, Francesco, Fusetti, Fabrizia, Deelen, Patrick, van Gosliga, Djoke, Vellenga, Edo, Schuringa, Jan Jacob

“…Interactions between hematopoietic stem cells and their niche are mediated by proteins within the plasma membrane (PM) and changes in these interactions might…”
Get full text

Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones by de Boer, Bauke, Prick, Janine, Pruis, Maurien G., Keane, Peter, Imperato, Maria Rosaria, Jaques, Jennifer, Brouwers-Vos, Annet Z., Hogeling, Shanna M., Woolthuis, Carolien M., Nijk, Marije T., Diepstra, Arjan, Wandinger, Sebastian, Versele, Matthias, Attar, Ricardo M., Cockerill, Peter N., Huls, Gerwin, Vellenga, Edo, Mulder, André B., Bonifer, Constanze, Schuringa, Jan Jacob

“…Intra-tumor heterogeneity caused by clonal evolution is a major problem in cancer treatment. To address this problem, we performed label-free quantitative…”
Get full text

Repression of BMI1 in normal and leukemic human CD34+ cells impairs self-renewal and induces apoptosis by Rizo, Aleksandra, Olthof, Sandra, Han, Lina, Vellenga, Edo, de Haan, Gerald, Schuringa, Jan Jacob

“…High expression of BMI1 in acute myeloid leukemia (AML) cells is associated with an unfavorable prognosis. Therefore, the effects of down-modulation of BMI1 in…”
Get full text

Inhibition of autophagy as a treatment strategy for p53 wild-type acute myeloid leukemia by Folkerts, Hendrik, Hilgendorf, Susan, Wierenga, Albertus T J, Jaques, Jennifer, Mulder, André B, Coffer, Paul J, Schuringa, Jan Jacob, Vellenga, Edo

“…Here we have explored whether inhibition of autophagy can be used as a treatment strategy for acute myeloid leukemia (AML). Steady-state autophagy was measured…”
Get full text

Autophagy Proteins ATG5 and ATG7 Are Essential for the Maintenance of Human CD34+ Hematopoietic Stem‐Progenitor Cells by Gomez‐Puerto, Maria Catalina, Folkerts, Hendrik, Wierenga, Albertus T.J., Schepers, Koen, Schuringa, Jan Jacob, Coffer, Paul J., Vellenga, Edo

“…Autophagy is a highly regulated catabolic process that involves sequestration and lysosomal degradation of cytosolic components such as damaged organelles and…”
Get full text

Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients by Broyl, Annemiek, Hose, Dirk, Lokhorst, Henk, de Knegt, Yvonne, Peeters, Justine, Jauch, Anna, Bertsch, Uta, Buijs, Arjan, Stevens-Kroef, Marian, Beverloo, H. Berna, Vellenga, Edo, Zweegman, Sonja, Kersten, Marie-Josée, van der Holt, Bronno, el Jarari, Laila, Mulligan, George, Goldschmidt, Hartmut, van Duin, Mark, Sonneveld, Pieter

“…To identify molecularly defined subgroups in multiple myeloma, gene expression profiling was performed on purified CD138+ plasma cells of 320 newly diagnosed…”
Get full text

Convergence of hypoxia and TGFβ pathways on cell cycle regulation in human hematopoietic stem/progenitor cells by Wierenga, Albertus T J, Vellenga, Edo, Schuringa, Jan Jacob

“…Although it has been shown that HIF1 and 2 fulfill essential roles within the hematopoietic system and in the regulation of HSC fate, little is currently known…”
Get full text

Phase 2 study of carfilzomib, thalidomide, and dexamethasone as induction/consolidation therapy for newly diagnosed multiple myeloma by Sonneveld, Pieter, Asselbergs, Emilie, Zweegman, Sonja, van der Holt, Bronno, Kersten, Marie Jose, Vellenga, Edo, van Marwijk-Kooy, Marinus, Broyl, Annemiek, de Weerdt, Okke, Lonergan, Sarah, Palumbo, Antonio, Lokhorst, Henk

“…This multicenter phase 2 study of the European Myeloma Network investigated the combination of carfilzomib, thalidomide, and dexamethasone (KTd) as…”
Get full text

ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia by Martens, Joost H.A., Mandoli, Amit, Simmer, Femke, Wierenga, Bart-Jan, Saeed, Sadia, Singh, Abhishek A., Altucci, Lucia, Vellenga, Edo, Stunnenberg, Hendrik G.

“…ERG and FLI1 are closely related members of the ETS family of transcription factors and have been identified as essential factors for the function and…”
Get full text

Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis by van den Boom, Vincent, Maat, Henny, Geugien, Marjan, Rodríguez López, Aida, Sotoca, Ana M., Jaques, Jennifer, Brouwers-Vos, Annet Z., Fusetti, Fabrizia, Groen, Richard W.J., Yuan, Huipin, Martens, Anton C.M., Stunnenberg, Hendrik G., Vellenga, Edo, Martens, Joost H.A., Schuringa, Jan Jacob

“…Polycomb proteins are classical regulators of stem cell self-renewal and cell lineage commitment and are frequently deregulated in cancer. Here, we find that…”
Get full text

Early detection and evolution of preleukemic clones in therapy-related myeloid neoplasms following autologous SCT by Berger, Gerbrig, Kroeze, Leonie I., Koorenhof-Scheele, Theresia N., de Graaf, Aniek O., Yoshida, Kenichi, Ueno, Hiroo, Shiraishi, Yuichi, Miyano, Satoru, van den Berg, Eva, Schepers, Hein, van der Reijden, Bert A., Ogawa, Seishi, Vellenga, Edo, Jansen, Joop H.

“…Therapy-related myeloid neoplasms (tMNs) are severe adverse events that can occur after treatment with autologous hematopoietic stem cell transplantation…”
Get full text