Search Results - "Vellayappan, Balamurugan A."

ROS and the DNA damage response in cancer by Srinivas, Upadhyayula Sai, Tan, Bryce W.Q., Vellayappan, Balamurugan A., Jeyasekharan, Anand D.

“…Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-containing molecules that can induce DNA damage and affect the DNA damage…”
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Cytokine Release Syndrome in Cancer Patients Receiving Immune Checkpoint Inhibitors: A Case Series of 25 Patients and Review of the Literature by Tay, Sen Hee, Toh, Michelle Min Xuan, Thian, Yee Liang, Vellayappan, Balamurugan A, Fairhurst, Anna-Marie, Chan, Yiong Huak, Aminkeng, Folefac, Bharwani, Lavina D, Huang, Yiqing, Mak, Anselm, Wong, Alvin Seng Cheong

“…Cytokine release syndrome (CRS) is a phenomenon of immune hyperactivation described in the setting of immunotherapy. Unlike other immune-related adverse…”
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Megavoltage Radiosensitization of Gold Nanoparticles on a Glioblastoma Cancer Cell Line Using a Clinical Platform by Kazmi, Farasat, Vallis, Katherine A, Vellayappan, Balamurugan A, Bandla, Aishwarya, Yukun, Duan, Carlisle, Robert

“…Gold nanoparticles (GNPs) have demonstrated significant dose enhancement with kilovoltage (kV) X-rays; however, recent studies have shown inconsistent findings…”
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Evaluation of ex vivo drug combination optimization platform in recurrent high grade astrocytic glioma: An interventional, non-randomized, open-label trial protocol by Toh, Tan Boon, Thng, Dexter Kai Hao, Bolem, Nagarjun, Vellayappan, Balamurugan A, Tan, Bryce Wei Quan, Shen, Yating, Soon, Sou Yen, Ang, Yvonne Li En, Dinesh, Nivedh, Teo, Kejia, Nga, Vincent Diong Weng, Low, Shiong Wen, Khong, Pek Lan, Chow, Edward Kai-Hua, Ho, Dean, Yeo, Tseng Tsai, Wong, Andrea Li Ann

“…High grade astrocytic glioma (HGG) is a lethal solid malignancy with high recurrence rates and limited survival. While several cytotoxic agents have…”
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The evolution and rise of stereotactic body radiotherapy (SBRT) for spinal metastases by Vellayappan, Balamurugan A., Chao, Samuel T., Foote, Matthew, Guckenberger, Matthias, Redmond, Kristin J., Chang, Eric L., Mayr, Nina A., Sahgal, Arjun, Lo, Simon S.

“…Introduction: Owing to improvements in clinical care and systemic therapy, more patients are being diagnosed with, and living longer with, spinal metastases…”
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Neoadjuvant short-course radiotherapy or chemoradiation plus consolidative chemotherapy followed by radical operation for locally advanced rectal cancer by Lee, Shing Fung, Yip, Pui Lam, Wo, Barry, Wong, Natalie Sean-Man, Vellayappan, Balamurugan A, Mamon, Harvey J, Lee, Francis Ann Shing

“…Limited evidence compares short-course radiotherapy (SCRT) and long-course chemoradiotherapy (LCCRT), both of which are followed by consolidative chemotherapy…”
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Radiation Necrosis from Stereotactic Radiosurgery—How Do We Mitigate? by Vellayappan, Balamurugan A., McGranahan, Tresa, Graber, Jerome, Taylor, Lynne, Venur, Vyshak, Ellenbogen, Richard, Sloan, Andrew E., Redmond, Kristin J., Foote, Matthew, Chao, Samuel T., Suh, John H., Chang, Eric L., Sahgal, Arjun, Lo, Simon S.

“…Opinion statement Intracranial stereotactic radiosurgery (SRS) is an effective and convenient treatment for many brain conditions. Data regarding safety come…”
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CURATE.AI COR-Tx platform as a digital therapy and digital diagnostic for cognitive function in patients with brain tumour postradiotherapy treatment: protocol for a prospective mixed-methods feasibility clinical trial by Remus, Alexandria, Tadeo, Xavier, Kai, Grady Ng Shi, Blasiak, Agata, Kee, Theodore, Vijayakumar, Smrithi, Nguyen, Le, Raczkowska, Marlena N, Chai, Qian Yee, Aliyah, Fatin, Rusalovski, Yaromir, Teo, Kejia, Yeo, Tseng Tsai, Wong, Andrea Li Ann, Chia, David, Asplund, Christopher L, Ho, Dean, Vellayappan, Balamurugan A

“…IntroductionConventional interventional modalities for preserving or improving cognitive function in patients with brain tumour undergoing radiotherapy usually…”
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Deep Learning Model for Classifying Metastatic Epidural Spinal Cord Compression on MRI by Hallinan, James Thomas Patrick Decourcy, Zhu, Lei, Zhang, Wenqiao, Lim, Desmond Shi Wei, Baskar, Sangeetha, Low, Xi Zhen, Yeong, Kuan Yuen, Teo, Ee Chin, Kumarakulasinghe, Nesaretnam Barr, Yap, Qai Ven, Chan, Yiong Huak, Lin, Shuxun, Tan, Jiong Hao, Kumar, Naresh, Vellayappan, Balamurugan A, Ooi, Beng Chin, Quek, Swee Tian, Makmur, Andrew

“…Metastatic epidural spinal cord compression (MESCC) is a devastating complication of advanced cancer. A deep learning (DL) model for automated MESCC…”
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Deep learning assessment compared to radiologist reporting for metastatic spinal cord compression on CT by Hallinan, James Thomas Patrick Decourcy, Zhu, Lei, Zhang, Wenqiao, Ge, Shuliang, Muhamat Nor, Faimee Erwan, Ong, Han Yang, Eide, Sterling Ellis, Cheng, Amanda J L, Kuah, Tricia, Lim, Desmond Shi Wei, Low, Xi Zhen, Yeong, Kuan Yuen, AlMuhaish, Mona I, Alsooreti, Ahmed Mohamed, Kumarakulasinghe, Nesaretnam Barr, Teo, Ee Chin, Yap, Qai Ven, Chan, Yiong Huak, Lin, Shuxun, Tan, Jiong Hao, Kumar, Naresh, Vellayappan, Balamurugan A, Ooi, Beng Chin, Quek, Swee Tian, Makmur, Andrew

“…Metastatic spinal cord compression (MSCC) is a disastrous complication of advanced malignancy. A deep learning (DL) algorithm for MSCC classification on CT…”
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Clinical characteristics and genetic testing outcome of suspected hereditary peripheral nerve sheath tumours in a tertiary cancer institution in Singapore by Loh, Jerold, Ong, Pei Yi, Goh, Denise Li Meng, Puhaindran, Mark E, Vellayappan, Balamurugan A, Ow, Samuel Guan Wei, Chan, Gloria, Lee, Soo-Chin

“…Peripheral Nerve Sheath Tumors (PNST) are a diverse group of mostly benign tumours uncommon in the general population. About 5-10% of PNSTs are hereditary,…”
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Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer by Vellayappan, Balamurugan A, Soon, Yu Yang, Ku, Geoffrey Y, Leong, Cheng Nang, Lu, Jiade J, Tey, Jeremy Cs

“…Please see Appendix 4 for a glossary of terms.The outcome of patients with esophageal cancer is generally poor. Although multimodal therapy is standard, there…”
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Is two-staged gamma knife surgery a reasonable management option for very large cerebellar metastases? A case series of three patients by Lo, Yu Tung, Karlsson, Bengt, Wong, Andrea, Vellayappan, Balamurugan A., Yeo, Tseng Tsai, Nga, Vincent Diong Weng

“…Objective Two-staged gamma knife surgery (GKS) is a method that may extend the upper tumor volume limit for using GKS in the management of brain metastases…”
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Stereotactic radiosurgery in alveolar soft part sarcoma brain metastases: Case series and literature review by Lim, Jia Xu, Karlsson, Bengt, Pang, Angela, Vellayappan, Balamurugan A., Nga, Vincent

“…•ASPS has the highest incidence of brain metastasis amongst sarcomas.•High prescription doses necessary to achieve local tumour control.•Retreatment of lesions…”
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Accuracy of 18F-flurodeoxyglucosepositron emission tomography/computed tomography in the staging of newly diagnosed nasopharyngeal carcinoma: a systematic review and meta-analysis by Vellayappan, Balamurugan A., Soon, Yu Yang, Earnest, Arul, Zhang, Qing, Koh, Wee Yao, Tham, Ivan Weng Keong, Lee, Khai Mun

“…Background. The specific role of 18F-flurodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in staging of nasopharyngeal carcinoma…”
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Radiation therapy with phenotypic medicine: towards N-of-1 personalization by Chong, Li Ming, Wang, Peter, Lee, V. Vien, Vijayakumar, Smrithi, Tan, Hong Qi, Wang, Fu Qiang, Yeoh, Teri Danielle You Ying, Truong, Anh T. L., Tan, Lester Wen Jeit, Tan, Shi Bei, Senthil Kumar, Kirthika, Hau, Eric, Vellayappan, Balamurugan A., Blasiak, Agata, Ho, Dean

“…In current clinical practice, radiotherapy (RT) is prescribed as a pre-determined total dose divided over daily doses (fractions) given over several weeks. The…”
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Is there an optimal timing between radiotherapy and surgery to reduce wound complications in metastatic spine disease? A systematic review by Kumar, Naresh, Madhu, Sirisha, Bohra, Hussain, Pandita, Naveen, Wang, Samuel Sherng Young, Lopez, Keith Gerard, Tan, Jiong Hao, Vellayappan, Balamurugan A.

“…Purpose Surgery with radiation therapy (RT) is more effective in treating spinal metastases, than RT alone. However, RT when administered in close proximity to…”
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An overview of the tumors affecting the spine—inside to out by Kumar, Naresh, Tan, Wei Loong Barry, Wei, Wei, Vellayappan, Balamurugan A

“…Abstract Spine tumors may arise within or surrounding the spinal cord and/or vertebral column. Spinal tumors can be benign or malignant. Based on their…”
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Novel 3D printable PEEK-HA-Mg2SiO4 composite material for spine implants: biocompatibility and imaging compatibility assessments by Kumar, Naresh, Alathur Ramakrishnan, Sridharan, Lopez, Keith Gerard, Wang, Niyou, Vellayappan, Balamurugan A., Hallinan, James Thomas Patrick Decourcy, Fuh, Jerry Ying Hsi, Kumar, A. Senthil

“…Purpose To develop a novel 3D printable polyether ether ketone (PEEK)-hydroxyapatite (HA)-magnesium orthosilicate (Mg 2 SiO 4 ) composite material with…”
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Evolution of materials for implants in metastatic spine disease till date – Have we found an ideal material? by Kumar, Naresh, Lopez, Keith Gerard, Alathur Ramakrishnan, Sridharan, Hallinan, James Thomas Patrick Decourcy, Fuh, Jerry Ying Hsi, Pandita, Naveen, Madhu, Sirisha, Kumar, Aravind, Benneker, Lorin M., Vellayappan, Balamurugan A.

“…•Evolution of stainless steel and Ti6Al4V implants in spine surgery.•Adaptation of Ti6Al4V implants to metastatic spine tumor surgery (MSTS)•Emergence of…”
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