Search Results - "Velghe, Imke"

HES6 knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells by De Vos, Tamara, Oatman, Nicole, Boehme, Lena, Putteman, Tom, Velghe, Imke, Van Droogenbroeck, Yana, De Munter, Stijn, Cesnekova, Michaela, Van Nieuwerburgh, Filip, Vandekerckhove, Bart, Philippe, Jan, Taghon, Tom

“…Hematopoiesis is driven by molecular mechanisms that induce differentiation and proliferation of hematopoietic stem cells and their progeny. This involves the…”
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GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate by Van de Walle, Inge, Dolens, Anne-Catherine, Durinck, Kaat, De Mulder, Katrien, Van Loocke, Wouter, Damle, Sagar, Waegemans, Els, De Medts, Jelle, Velghe, Imke, De Smedt, Magda, Vandekerckhove, Bart, Kerre, Tessa, Plum, Jean, Leclercq, Georges, Rothenberg, Ellen V., Van Vlierberghe, Pieter, Speleman, Frank, Taghon, Tom

“…The gradual reprogramming of haematopoietic precursors into the T-cell fate is characterized by at least two sequential developmental stages. Following…”
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In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis by Vanhee, Stijn, De Mulder, Katrien, Van Caeneghem, Yasmine, Verstichel, Greet, Van Roy, Nadine, Menten, Björn, Velghe, Imke, Philippé, Jan, De Bleser, Dominique, Lambrecht, Bart N, Taghon, Tom, Leclercq, Georges, Kerre, Tessa, Vandekerckhove, Bart

“…Although hematopoietic precursor activity can be generated in vitro from human embryonic stem cells, there is no solid evidence for the appearance of…”
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Functionally Mature CD4 and CD8 TCRαβ Cells Are Generated in OP9-DL1 Cultures from Human CD34+ Hematopoietic Cells by Van Coppernolle, Stefanie, Verstichel, Greet, Timmermans, Frank, Velghe, Imke, Vermijlen, David, De Smedt, Magda, Leclercq, Georges, Plum, Jean, Taghon, Tom, Vandekerckhove, Bart, Kerre, Tessa

“…Abstract Human CD34+ hematopoietic precursor cells cultured on delta-like ligand 1 expressing OP9 (OP9-DL1) stromal cells differentiate to T lineage cells. The…”
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RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia by SNAUWAERT, Sylvia, VANHEE, Stijn, LECIERCQ, Georges, THIELEMANS, Kris, KERRE, Tessa, VANDEKERCKHOVE, Bart, GOETGELUK, Glenn, VERSTICHEL, Greet, VAN CAENEGHEM, Yasmine, VELGHE, Imke, PHILIPPE, Jan, BERNEMAN, Zwi N, PLUM, Jean, TAGHON, Tom

“…Criteria for good candidate antigens for immunotherapy of acute myeloid leukemia are high expression on leukemic stem cells in the majority of patients with…”
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HES6knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells by De Vos, Tamara, Oatman, Nicole, Boehme, Lena, Putteman, Tom, Velghe, Imke, Van Droogenbroeck, Yana, De Munter, Stijn, Cesnekova, Michaela, Van Nieuwerburgh, Filip, Vandekerckhove, Bart, Philippe, Jan, Taghon, Tom

“…Hematopoiesis is driven by molecular mechanisms that induce differentiation and proliferation of hematopoietic stem cells and their progeny. This involves the…”
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An unexpected role for IRF8 during human T cell development by Taghon, Tom N, Liang, Kai Ling, Lavaert, Marieke, Roels, Juliette, Strubbe, Steven, Lambrechts, Nina, De Vos, Tamara, Boehme, Lena, Van Hulle, Jolien, Oatman, Nicole, Putteman, Tom, Velghe, Imke

“…Abstract Lineage tracing studies or other genetic approaches have allowed investigators to obtain detailed insights into the molecular mechanisms that control…”
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Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF by Liang, Kai Ling, Roels, Juliette, Lavaert, Marieke, Putteman, Tom, Boehme, Lena, Tilleman, Laurentijn, Velghe, Imke, Pegoretti, Valentina, Van de Walle, Inge, Sontag, Stephanie, Vandewalle, Jolien, Vandekerckhove, Bart, Leclercq, Georges, Van Vlierberghe, Pieter, Libert, Claude, Van Nieuwerburgh, Filip, Fischer, Roman, Kontermann, Roland E., Pfizenmaier, Klaus, Doody, Gina, Zenke, Martin, Taghon, Tom

“…The cross-talk between thymocytes and thymic stromal cells is fundamental for T cell development. In humans, intrathymic development of dendritic cells (DCs)…”
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Generation of T Cells from Human Embryonic Stem Cell-Derived Hematopoietic Zones by Timmermans, Frank, Velghe, Imke, Vanwalleghem, Lieve, De Smedt, Magda, Van Coppernolle, Stefanie, Taghon, Tom, Moore, Harry D, Leclercq, Georges, Langerak, Anton W, Kerre, Tessa, Plum, Jean, Vandekerckhove, Bart

“…Human embryonic stem cells (hESC) are pluripotent stem cells. A major challenge in the field of hESC is the establishment of specific differentiation protocols…”
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Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development by Dolens, Anne‐Catherine, Durinck, Kaat, Lavaert, Marieke, Van der Meulen, Joni, Velghe, Imke, De Medts, Jelle, Weening, Karin, Roels, Juliette, De Mulder, Katrien, Volders, Pieter‐Jan, De Preter, Katleen, Kerre, Tessa, Vandekerckhove, Bart, Leclercq, Georges, Vandesompele, Jo, Mestdagh, Pieter, Van Vlierberghe, Pieter, Speleman, Frank, Taghon, Tom

“…γδ and αβ T cells have unique roles in immunity and both originate in the thymus from T‐lineage committed precursors through distinct but unclear mechanisms…”
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In vitro human embryonic stem cell hematopoiesis mimics MYB independent yolk sac hematopoiesis by Vanhee, Stijn, De Mulder, Katrien, Van Caeneghem, Yasmine, Van Roy, Nadine, Menten, Björn, Velghe, Imke, Philippé, Jan, Taghon, Tom, Leclercq, Georges, Kerre, Tessa, Vandekerckhove, Bart

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In vitro generation of immune cells from pluripotent stem cells by Vandekerckhove, Bart, Vanhee, Stijn, Van Coppernolle, Stefanie, Snauwaert, Sylvia, Velghe, Imke, Taghon, Tom, Leclercq, Georges, Kerre, Tessa, Plum, Jean

“…Stem cell transplant recipients and acquired or inherited immune-deficiency patients could benefit from the infusion of B, T and/or NK cells. These lymphoid…”
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cMYB expression during human in vitro hematopoiesis by Vanhee, Stijn, Van Caeneghem, Yasmine, De Mulder, Katrien, Velghe, Imke, Taveirne, Sylvie, Van Roy, Nadine, Menten, Björn, Snauwaert, Sylvia, Verstichel, Greet, Dullaers, Melissa, Goetgeluk, Glenn, Leclercq, Georges, Taghon, Tom, Plum, Jean, Kerre, Tessa, Vandekerckhove, Bart

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CD4 and CD8 TCRαβ Cells Are selected On MHC Expressed On Thymocyte Precursors in OP9-DL1 Cultures by Van Coppernolle, Stefanie, Vandekerckhove, Bart, Verstichel, Greet, Velghe, Imke, Taghon, Tom, Leclercq, Georges, Plum, Jean, Kerre, Tessa C.C.

“…Abstract 3670 Poster Board III-606 Human CD34+ haematopoietic precursor cells cultured on delta-like-ligand 1 expressing OP9 (OP9-DL1) stromal cells…”
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OP9-DL1 Cell Line Supports the Development of Phenotypically and Functionally Mature Tcrαβ And Tcrγδ T Cells, through Both Conventional and Aberrant Developmental Pathways by Kerre, Tessa C.C., Verstichel, Greet, Van Coppernolle, Stefanie, Velghe, Imke, Timmermans, Frank, Plum, Jean, Vandekerckhove, Bart

“…In vitro generation of mature T cells from human hematopoietic stem and progenitor cells (HSPC) could fulfill two existing needs. First, it could enhance and…”
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Generation of T Cells from Human Embryonic Stem Cells by Timmermans, Frank, Velghe, Imke, Van Walleghem, Lieve, De Smedt, Magda, Van Coppernolle, Stefanie, Leclercq, Georges, Taghon, Tom, Moore, Harry, Langerak, Anton W, Kerre, Tessa C.C., Plum, Jean, Vandekerckhove, Bart

“…Background: Human embryonic stem cells (hESC) are derived from early stage blastocysts and are characterized by the ability to both self-renew and to generate…”
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Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells by Van Coppernolle, Stefanie, Verstichel, Greet, Timmermans, Frank, Velghe, Imke, Vermijlen, David, De Smedt, Magda, Leclercq, Georges, Plum, Jean, Taghon, Tom, Vandekerckhove, Bart, Kerre, Tessa

“…Human CD34(+) hematopoietic precursor cells cultured on delta-like ligand 1 expressing OP9 (OP9-DL1) stromal cells differentiate to T lineage cells. The nature…”
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Functionally Mature CD4 and CD8 TCR{alpha}{beta} Cells Are Generated in OP9-DL1 Cultures from Human CD34+ Hematopoietic Cells by Van Coppernolle, Stefanie, Verstichel, Greet, Timmermans, Frank, Velghe, Imke, Vermijlen, David, De Smedt, Magda, Leclercq, Georges, Plum, Jean, Taghon, Tom, Vandekerckhove, Bart, Kerre, Tessa

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