Comparative Analysis of Stromal Vascular Fraction and Alternative Mechanisms in Bone Fracture Stimulation to Bridge the Gap between Nature and Technological Advancement: A Systematic Review

Comparative Analysis of Stromal Vascular Fraction and Alternative Mechanisms in Bone Fracture Stimulation to Bridge the Gap between Nature and Technological Advancement: A Systematic Review

Various stimulation methods, including electrical, ultrasound, mechanical, and biological interventions, are explored, each leveraging intricate cellular and molecular dynamics to expedite healing. The advent of stromal vascular fraction (SVF) marks a significant stride, offering multifarious benefi...

Full description

Saved in:
Bibliographic Details
Published in:Biomedicines Vol. 12; no. 2; p. 342
Main Authors: Goncharov, Evgeniy Nikolaevich, Koval, Oleg Aleksandrovich, Nikolaevich Bezuglov, Eduard, Engelgard, Mikhail, Igorevich, Eremin Ilya, Velentinovich Kotenko, Konstantin, Encarnacion Ramirez, Manuel De Jesus, Montemurro, Nicola
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-02-2024
Subjects:
19th century
Analysis
Bone growth
Bone healing
Comparative analysis
Cytokines
Electric properties
Electrodes
Electromagnetism
Fibroblasts
Flow cytometry
Fractures
graft survival
Growth factors
Health aspects
Inflammation
Literature reviews
Mechanical stimuli
Molecular dynamics
Osteogenesis
Osteoporosis
Regeneration
regenerative medicine
Reviews
Stem cells
stromal vascular fraction
surgery
tissue regeneration
Ultrasonic imaging
Ultrasound
Vibration
graft survival
tissue regeneration
stromal vascular fraction
regenerative medicine
surgery
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Various stimulation methods, including electrical, ultrasound, mechanical, and biological interventions, are explored, each leveraging intricate cellular and molecular dynamics to expedite healing. The advent of stromal vascular fraction (SVF) marks a significant stride, offering multifarious benefits in bone healing, from enhanced bone formation to optimal vascular integration, drawing a harmonious balance between innate mechanisms and scientific advancements. This systematic review was conducted focusing on literature from 2016 to 2023 and encompassing various bone healing stimulation mechanisms like SVF, electrical, ultrasound, and mechanical stimulation. The extracted data underwent meticulous synthesis and analysis, emphasizing comparative evaluations of mechanisms, applications, and outcomes of each intervention. The reviewed studies reveal the potential of SVF in bone fracture healing, with its regenerative and anti-inflammatory effects. The purification of SVF is crucial for safe therapeutic use. Characterization involves flow cytometry and microscopy. Studies show SVF's efficacy in bone regeneration, versatility in various contexts, and potential for clinical use. SVF appears superior to electrical, ultrasound, and mechanical stimulation, with low complications. This review compares bone healing methods, including SVF. It provides valuable insights into SVF's potential for bone regeneration. However, due to limited human studies and potential bias, cautious interpretation is necessary. Further research is essential to validate these findings and determine the optimal SVF applications in bone healing.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12020342