Search Results - "Veldhuizen, Ruud A.W"

Current perspectives in pulmonary surfactant — Inhibition, enhancement and evaluation by Zuo, Yi Y., Veldhuizen, Ruud A.W., Neumann, A. Wilhelm, Petersen, Nils O., Possmayer, Fred

“…Pulmonary surfactant (PS) is a complicated mixture of approximately 90% lipids and 10% proteins. It plays an important role in maintaining normal respiratory…”
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Lung lavage and surfactant replacement during ex vivo lung perfusion for treatment of gastric acid aspiration-induced donor lung injury by Nakajima, Daisuke, Liu, Mingyao, Ohsumi, Akihiro, Kalaf, Ricardo, Iskender, Ilker, Hsin, Michael, Kanou, Takashi, Chen, Manyin, Baer, Brandon, Coutinho, Rafael, Maahs, Lucas, Behrens, Paula, Azad, Sassan, Martinu, Tereza, Waddell, Thomas K, Lewis, James F, Post, Martin, Veldhuizen, Ruud A.W, Cypel, Marcelo, Keshavjee, Shaf

“…Background Ex vivo lung perfusion (EVLP) provides opportunities to treat injured donor lungs before transplantation. We investigated whether lung lavage, to…”
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The effect of maternal protein restriction during perinatal life on the inflammatory response in pediatric rats by Veldhuizen, Ruud A W, Baer, Brandon, McCaig, Lynda A, Solomon, Lauren A, Cameron, Lisa, Hardy, Daniel B

“…Fetal growth restriction can affect health outcomes in postnatal life. This study tested the hypothesis that the response to an inflammatory pulmonary insult…”
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Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome by Rizzo, Alicia N, Haeger, Sarah M, Oshima, Kaori, Yang, Yimu, Wallbank, Alison M, Jin, Ying, Lettau, Marie, McCaig, Lynda A, Wickersham, Nancy E, McNeil, J Brennan, Zakharevich, Igor, McMurtry, Sarah A, Langouët-Astrié, Christophe J, Kopf, Katrina W, Voelker, Dennis R, Hansen, Kirk C, Shaver, Ciara M, Kerchberger, V Eric, Peterson, Ryan A, Kuebler, Wolfgang M, Ochs, Matthias, Veldhuizen, Ruud Aw, Smith, Bradford J, Ware, Lorraine B, Bastarache, Julie A, Schmidt, Eric P

“…Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure yet has few pharmacologic therapies, reflecting the mechanistic…”
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Specific cleavage of the lung surfactant protein A by human cathepsin S may impair its antibacterial properties by Lecaille, Fabien, Naudin, Clément, Sage, Juliette, Joulin-Giet, Alix, Courty, Agnès, Andrault, Pierre-Marie, Veldhuizen, Ruud A.W., Possmayer, Fred, Lalmanach, Gilles

“…•Lung SP-A that participates to innate host defense is degraded in sputum of CF patients.•Cathepsin S cleaves specifically SP-A within its carbohydrate…”
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The effect of matrix metalloproteinase-3 deficiency on pulmonary surfactant in a mouse model of acute lung injury by Yamashita, Cory M, Cybulskie, Candice, Milos, Scott, Zuo, Yi Y, McCaig, Lynda A, Veldhuizen, Ruud A W

“…The acute respiratory distress syndrome (ARDS) is characterized by arterial hypoxemia accompanied by severe inflammation and alterations to the pulmonary…”
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Systemic and cerebral inflammatory response to umbilical cord occlusions with worsening acidosis in the ovine fetus by Prout, Andrew P., MSc, Frasch, Martin G., MD, PhD, Veldhuizen, Ruud A.W., PhD, Hammond, Rob, MD, Ross, Michael G., MD, Richardson, Bryan S., MD

“…Objective We hypothesized that repetitive umbilical cord occlusions (UCOs) with worsening acidosis will lead to a fetal inflammatory response. Study Design…”
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Recent advances in alveolar biology: Some new looks at the alveolar interface by Possmayer, Fred, Hall, Stephen B, Haller, Thomas, Petersen, Nils O, Zuo, Yi Y, Bernardino de la Serna, Jorge, Postle, Anthony D, Veldhuizen, Ruud A.W, Orgeig, Sandra

“…Abstract This article examines the manner in which some new methodologies and novel concepts have contributed to our understanding of how pulmonary surfactant…”
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IL -6 and TNFα across the umbilical circulation in term pregnancies: Relationship with labour events by Duncombe, Greg, Veldhuizen, Ruud A.W, Gratton, Robert J, Han, Victor K.M, Richardson, Bryan S

“…Abstract Objective We have determined venous and arterial cord blood levels for IL -6 and TNFα at the time of delivery to assess gestational tissue versus…”
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High-frequency oscillation and surfactant treatment in an acid aspiration model by Aspros, Alexander J, Coto, Claudia G, Lewis, James F, Veldhuizen, Ruud A W

“…Both exogenous surfactant therapy and high-frequency oscillation (HFO) have been proposed as clinical interventions in acute respiratory distress syndrome…”
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Pulmonary Surfactant: A Mighty Thin Film by Possmayer, Fred, Zuo, Yi Y., Veldhuizen, Ruud A. W., Petersen, Nils O.

“…Pulmonary surfactant is a critical component of lung function in healthy individuals. It functions in part by lowering surface tension in the alveoli, thereby…”
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New insights into exogenous surfactant as a carrier of pulmonary therapeutics by Baer, Brandon, Souza, Lucas Miguel Pereira, Pimentel, André Silva, Veldhuizen, Ruud A.W.

“…[Display omitted] As an organ system, the lung has unique advantages and disadvantages for localized drug delivery. Its direct contact with the external…”
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Novel Functions and Signaling Specificity for the GraS Sensor Kinase of Staphylococcus aureus in Response to Acidic pH by Kuiack, Robert C, Veldhuizen, Ruud A W, McGavin, Martin J

“…Although the GraS sensor kinase of is known for the sensing of and resistance to cationic antimicrobial peptides (CAMPs), we recently established that it also…”
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The COVID-19 pandemic: a target for surfactant therapy? by Veldhuizen, Ruud A W, Zuo, Yi Y, Petersen, Nils O, Lewis, James F, Possmayer, Fred

“…The dramatic impact of COVID-19 on humans worldwide has initiated an extraordinary search for effective treatment approaches. One of these is the…”
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Lung remodeling associated with recovery from acute lung injury by Gill, Sean E., Yamashita, Cory M., Veldhuizen, Ruud A. W.

“…Acute respiratory distress syndrome (ARDS) is a disease with a variety of causes and is defined by severe hypoxemia. Whereas ARDS carries a mortality of…”
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A modified squeeze-out mechanism for generating high surface pressures with pulmonary surfactant by Keating, Eleonora, Zuo, Yi Y., Tadayyon, Seyed M., Petersen, Nils O., Possmayer, Fred, Veldhuizen, Ruud A.W.

“…The exact mechanism by which pulmonary surfactant films reach the very low surface tensions required to stabilize the alveoli at end expiration remains…”
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Killing of Pseudomonas aeruginosa by Chicken Cathelicidin-2 Is Immunogenically Silent, Preventing Lung Inflammation In Vivo by Coorens, Maarten, Banaschewski, Brandon J H, Baer, Brandon J, Yamashita, Cory, van Dijk, Albert, Haagsman, Henk P, Veldhuizen, Ruud A W, Veldhuizen, Edwin J A

“…The development of antibiotic resistance by is a major concern in the treatment of bacterial pneumonia. In the search for novel anti-infective therapies, the…”
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Bronchopneumonia with interstitial pneumonia in beef feedlot cattle: Characterization and laboratory investigation by Haydock, Luke A. J., Fenton, R. Kent, Sergejewich, Lauren, Veldhuizen, Ruud A. W., Smerek, Dani, Ojkic, Davor, Caswell, Jeff L.

“…Bronchopneumonia with interstitial pneumonia (BIP) has been considered a variant of acute interstitial pneumonia (AIP) rather than a distinct disease. This…”
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Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice by Tyml, Karel, Swarbreck, Scott, Pape, Cynthia, Secor, Dan, Koropatnick, James, Feng, Qingping, Veldhuizen, Ruud A W, Gill, Sean E

“…Despite many animal studies and clinical trials, mortality in sepsis remains high. This may be due to the fact that most experimental studies of sepsis employ…”
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Antimicrobial and biophysical properties of surfactant supplemented with an antimicrobial peptide for treatment of bacterial pneumonia by Banaschewski, Brandon J H, Veldhuizen, Edwin J A, Keating, Eleonora, Haagsman, Henk P, Zuo, Yi Y, Yamashita, Cory M, Veldhuizen, Ruud A W

“…Antibiotic-resistant bacterial infections represent an emerging health concern in clinical settings, and a lack of novel developments in the pharmaceutical…”
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