Search Results - "Veldhuizen, Ruud A. W"

Lung remodeling associated with recovery from acute lung injury by Gill, Sean E., Yamashita, Cory M., Veldhuizen, Ruud A. W.

“…Acute respiratory distress syndrome (ARDS) is a disease with a variety of causes and is defined by severe hypoxemia. Whereas ARDS carries a mortality of…”
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Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice by Tyml, Karel, Swarbreck, Scott, Pape, Cynthia, Secor, Dan, Koropatnick, James, Feng, Qingping, Veldhuizen, Ruud A W, Gill, Sean E

“…Despite many animal studies and clinical trials, mortality in sepsis remains high. This may be due to the fact that most experimental studies of sepsis employ…”
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Maternal protein restriction during perinatal life affects lung mechanics and the surfactant system during early postnatal life in female rats by Khazaee, Reza, McCaig, Lynda A, Yamashita, Cory, Hardy, Daniel B, Veldhuizen, Ruud A W

“…Limited information is available on how fetal growth retardation (FGR) affects the lung in the neonatal period in males and females. This led us to test the…”
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Human alveolar epithelial cells attenuate pulmonary microvascular endothelial cell permeability under septic conditions by Wang, Lefeng, Taneja, Ravi, Wang, Wei, Yao, Li-Juan, Veldhuizen, Ruud A W, Gill, Sean E, Fortin, Dalilah, Inculet, Richard, Malthaner, Richard, Mehta, Sanjay

“…Acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS), are characterised by high-protein pulmonary edema and severe…”
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Antimicrobial and biophysical properties of surfactant supplemented with an antimicrobial peptide for treatment of bacterial pneumonia by Banaschewski, Brandon J H, Veldhuizen, Edwin J A, Keating, Eleonora, Haagsman, Henk P, Zuo, Yi Y, Yamashita, Cory M, Veldhuizen, Ruud A W

“…Antibiotic-resistant bacterial infections represent an emerging health concern in clinical settings, and a lack of novel developments in the pharmaceutical…”
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National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research by Mendelson, Asher A., Lansdell, Casey, Fox-Robichaud, Alison E., Liaw, Patricia, Arora, Jaskirat, Cailhier, Jean-François, Cepinskas, Gediminas, Charbonney, Emmanuel, dos Santos, Claudia, Dwivedi, Dhruva, Ellis, Christopher G., Fergusson, Dean, Fiest, Kirsten, Gill, Sean E., Hendrick, Kathryn, Hunniford, Victoria T., Kowalewska, Paulina M., Krewulak, Karla, Lehmann, Christian, Macala, Kimberly, Marshall, John C., Mawdsley, Laura, McDonald, Braedon, McDonald, Ellen, Medeiros, Sarah K., Muniz, Valdirene S., Osuchowski, Marcin, Presseau, Justin, Sharma, Neha, Sohrabipour, Sahar, Sunohara-Neilson, Janet, Vázquez-Grande, Gloria, Veldhuizen, Ruud A. W., Welsh, Donald, Winston, Brent W., Zarychanski, Ryan, Zhang, Haibo, Zhou, Juan, Lalu, Manoj M.

“…Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. Factors…”
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Novel Functions and Signaling Specificity for the GraS Sensor Kinase of Staphylococcus aureus in Response to Acidic pH by Kuiack, Robert C, Veldhuizen, Ruud A W, McGavin, Martin J

“…Although the GraS sensor kinase of is known for the sensing of and resistance to cationic antimicrobial peptides (CAMPs), we recently established that it also…”
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Pseudomonas aeruginosa protease IV degrades surfactant proteins and inhibits surfactant host defense and biophysical functions by Malloy, Jaret L, Veldhuizen, Ruud A W, Thibodeaux, Brett A, O'Callaghan, Richard J, Wright, Jo Rae

“…Pulmonary surfactant has two distinct functions within the lung: reduction of surface tension at the air-liquid interface and participation in innate host…”
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Swept under the carpet? The role of mucociliary clearance in ventilator-induced lung injury by Yamashita, Cory M., Veldhuizen, Ruud A. W.

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Effect of Acute Lung Injury on Structure and Function of Pulmonary Surfactant Films by Panda, Amiya K, Nag, Kaushik, Harbottle, Robert R, Rodriguez-Capote, Karina, Veldhuizen, Ruud A. W, Petersen, Nils O, Possmayer, Fred

“…The structural and functional alterations in pulmonary surfactant that occur during acute lung injury were studied using rat lung surfactant large aggregates…”
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Role of cholesterol in the biophysical dysfunction of surfactant in ventilator-induced lung injury by Vockeroth, Dan, Gunasekara, Lasantha, Amrein, Matthias, Possmayer, Fred, Lewis, James F, Veldhuizen, Ruud A W

“…Mechanical ventilation may lead to an impairment of the endogenous surfactant system, which is one of the mechanisms by which this intervention contributes to…”
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The effect of maternal protein restriction during perinatal life on the inflammatory response in pediatric rats by Veldhuizen, Ruud A W, Baer, Brandon, McCaig, Lynda A, Solomon, Lauren A, Cameron, Lisa, Hardy, Daniel B

“…Fetal growth restriction can affect health outcomes in postnatal life. This study tested the hypothesis that the response to an inflammatory pulmonary insult…”
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Contribution of alveolar macrophages to the response of the TIMP-3 null lung during a septic insult by Martin, Erica L, Sheikh, Tanya A, Leco, Kevin J, Lewis, James F, Veldhuizen, Ruud A W

“…Mice deficient in tissue inhibitor of metalloproteinase-3 (TIMP-3) develop an emphysema-like phenotype involving increased pulmonary compliance, tissue…”
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Systemic and cerebral inflammatory response to umbilical cord occlusions with worsening acidosis in the ovine fetus by Prout, Andrew P., MSc, Frasch, Martin G., MD, PhD, Veldhuizen, Ruud A.W., PhD, Hammond, Rob, MD, Ross, Michael G., MD, Richardson, Bryan S., MD

“…Objective We hypothesized that repetitive umbilical cord occlusions (UCOs) with worsening acidosis will lead to a fetal inflammatory response. Study Design…”
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Physiological effects of oxidized exogenous surfactant in vivo: effects of high tidal volume and surfactant protein A by Bailey, Timothy C, Maruscak, Adam A, Petersen, Anne, White, Sarah, Lewis, James F, Veldhuizen, Ruud A W

“…Oxidative damage to surfactant can decrease lung function in vivo. In the current study, our two objectives were: 1) to examine whether the adverse effects of…”
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Recent advances in alveolar biology: Some new looks at the alveolar interface by Possmayer, Fred, Hall, Stephen B, Haller, Thomas, Petersen, Nils O, Zuo, Yi Y, Bernardino de la Serna, Jorge, Postle, Anthony D, Veldhuizen, Ruud A.W, Orgeig, Sandra

“…Abstract This article examines the manner in which some new methodologies and novel concepts have contributed to our understanding of how pulmonary surfactant…”
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Atomic Force Microscopy Studies of Functional and Dysfunctional Pulmonary Surfactant Films. I. Micro- and Nanostructures of Functional Pulmonary Surfactant Films and the Effect of SP-A by Zuo, Yi Y., Keating, Eleonora, Zhao, Lin, Tadayyon, Seyed M., Veldhuizen, Ruud A.W., Petersen, Nils O., Possmayer, Fred

“…Monolayers of a functional pulmonary surfactant (PS) can reach very low surface tensions well below their equilibrium value. The mechanism by which PS…”
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Pulmonary Surfactant: A Mighty Thin Film by Possmayer, Fred, Zuo, Yi Y., Veldhuizen, Ruud A. W., Petersen, Nils O.

“…Pulmonary surfactant is a critical component of lung function in healthy individuals. It functions in part by lowering surface tension in the alveoli, thereby…”
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The effect of matrix metalloproteinase-3 deficiency on pulmonary surfactant in a mouse model of acute lung injury by Yamashita, Cory M, Cybulskie, Candice, Milos, Scott, Zuo, Yi Y, McCaig, Lynda A, Veldhuizen, Ruud A W

“…The acute respiratory distress syndrome (ARDS) is characterized by arterial hypoxemia accompanied by severe inflammation and alterations to the pulmonary…”
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Physiological and inflammatory response to instillation of an oxidized surfactant in a rat model of surfactant deficiency by Bailey, Timothy C, Da Silva, Keith A, Lewis, James F, Rodriguez-Capote, Karina, Possmayer, Fred, Veldhuizen, Ruud A. W

“…Departments of 1 Physiology and Pharmacology, 2 Biochemistry, and 3 Medicine, Lawson Health Research Institute, University of Western Ontario, London, Ontario,…”
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