Search Results - "Veldhuizen, Ruud"

Lung remodeling associated with recovery from acute lung injury by Gill, Sean E., Yamashita, Cory M., Veldhuizen, Ruud A. W.

“…Acute respiratory distress syndrome (ARDS) is a disease with a variety of causes and is defined by severe hypoxemia. Whereas ARDS carries a mortality of…”
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Pulmonary Surfactant: A Mighty Thin Film by Possmayer, Fred, Zuo, Yi Y., Veldhuizen, Ruud A. W., Petersen, Nils O.

“…Pulmonary surfactant is a critical component of lung function in healthy individuals. It functions in part by lowering surface tension in the alveoli, thereby…”
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Novel Functions and Signaling Specificity for the GraS Sensor Kinase of Staphylococcus aureus in Response to Acidic pH by Kuiack, Robert C, Veldhuizen, Ruud A W, McGavin, Martin J

“…Although the GraS sensor kinase of is known for the sensing of and resistance to cationic antimicrobial peptides (CAMPs), we recently established that it also…”
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Maternal protein restriction during perinatal life affects lung mechanics and the surfactant system during early postnatal life in female rats by Khazaee, Reza, McCaig, Lynda A, Yamashita, Cory, Hardy, Daniel B, Veldhuizen, Ruud A W

“…Limited information is available on how fetal growth retardation (FGR) affects the lung in the neonatal period in males and females. This led us to test the…”
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New insights into exogenous surfactant as a carrier of pulmonary therapeutics by Baer, Brandon, Souza, Lucas Miguel Pereira, Pimentel, André Silva, Veldhuizen, Ruud A.W.

“…[Display omitted] As an organ system, the lung has unique advantages and disadvantages for localized drug delivery. Its direct contact with the external…”
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Lung lavage and surfactant replacement during ex vivo lung perfusion for treatment of gastric acid aspiration-induced donor lung injury by Nakajima, Daisuke, Liu, Mingyao, Ohsumi, Akihiro, Kalaf, Ricardo, Iskender, Ilker, Hsin, Michael, Kanou, Takashi, Chen, Manyin, Baer, Brandon, Coutinho, Rafael, Maahs, Lucas, Behrens, Paula, Azad, Sassan, Martinu, Tereza, Waddell, Thomas K, Lewis, James F, Post, Martin, Veldhuizen, Ruud A.W, Cypel, Marcelo, Keshavjee, Shaf

“…Background Ex vivo lung perfusion (EVLP) provides opportunities to treat injured donor lungs before transplantation. We investigated whether lung lavage, to…”
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Current perspectives in pulmonary surfactant — Inhibition, enhancement and evaluation by Zuo, Yi Y., Veldhuizen, Ruud A.W., Neumann, A. Wilhelm, Petersen, Nils O., Possmayer, Fred

“…Pulmonary surfactant (PS) is a complicated mixture of approximately 90% lipids and 10% proteins. It plays an important role in maintaining normal respiratory…”
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Antimicrobial and biophysical properties of surfactant supplemented with an antimicrobial peptide for treatment of bacterial pneumonia by Banaschewski, Brandon J H, Veldhuizen, Edwin J A, Keating, Eleonora, Haagsman, Henk P, Zuo, Yi Y, Yamashita, Cory M, Veldhuizen, Ruud A W

“…Antibiotic-resistant bacterial infections represent an emerging health concern in clinical settings, and a lack of novel developments in the pharmaceutical…”
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Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice by Tyml, Karel, Swarbreck, Scott, Pape, Cynthia, Secor, Dan, Koropatnick, James, Feng, Qingping, Veldhuizen, Ruud A W, Gill, Sean E

“…Despite many animal studies and clinical trials, mortality in sepsis remains high. This may be due to the fact that most experimental studies of sepsis employ…”
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Human alveolar epithelial cells attenuate pulmonary microvascular endothelial cell permeability under septic conditions by Wang, Lefeng, Taneja, Ravi, Wang, Wei, Yao, Li-Juan, Veldhuizen, Ruud A W, Gill, Sean E, Fortin, Dalilah, Inculet, Richard, Malthaner, Richard, Mehta, Sanjay

“…Acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS), are characterised by high-protein pulmonary edema and severe…”
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The effect of maternal protein restriction during perinatal life on the inflammatory response in pediatric rats by Veldhuizen, Ruud A W, Baer, Brandon, McCaig, Lynda A, Solomon, Lauren A, Cameron, Lisa, Hardy, Daniel B

“…Fetal growth restriction can affect health outcomes in postnatal life. This study tested the hypothesis that the response to an inflammatory pulmonary insult…”
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The COVID-19 pandemic: a target for surfactant therapy? by Veldhuizen, Ruud A W, Zuo, Yi Y, Petersen, Nils O, Lewis, James F, Possmayer, Fred

“…The dramatic impact of COVID-19 on humans worldwide has initiated an extraordinary search for effective treatment approaches. One of these is the…”
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Specific cleavage of the lung surfactant protein A by human cathepsin S may impair its antibacterial properties by Lecaille, Fabien, Naudin, Clément, Sage, Juliette, Joulin-Giet, Alix, Courty, Agnès, Andrault, Pierre-Marie, Veldhuizen, Ruud A.W., Possmayer, Fred, Lalmanach, Gilles

“…•Lung SP-A that participates to innate host defense is degraded in sputum of CF patients.•Cathepsin S cleaves specifically SP-A within its carbohydrate…”
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A modified squeeze-out mechanism for generating high surface pressures with pulmonary surfactant by Keating, Eleonora, Zuo, Yi Y., Tadayyon, Seyed M., Petersen, Nils O., Possmayer, Fred, Veldhuizen, Ruud A.W.

“…The exact mechanism by which pulmonary surfactant films reach the very low surface tensions required to stabilize the alveoli at end expiration remains…”
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Killing of Pseudomonas aeruginosa by Chicken Cathelicidin-2 Is Immunogenically Silent, Preventing Lung Inflammation In Vivo by Coorens, Maarten, Banaschewski, Brandon J H, Baer, Brandon J, Yamashita, Cory, van Dijk, Albert, Haagsman, Henk P, Veldhuizen, Ruud A W, Veldhuizen, Edwin J A

“…The development of antibiotic resistance by is a major concern in the treatment of bacterial pneumonia. In the search for novel anti-infective therapies, the…”
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Collagen Tubular Airway‐on‐Chip for Extended Epithelial Culture and Investigation of Ventilation Dynamics (Small 27/2024) by Gao, Wuyang, Kanagarajah, Kayshani R., Graham, Emma, Soon, Kayla, Veres, Teodor, Moraes, Theo J., Bear, Christine E., Veldhuizen, Ruud A., Wong, Amy P., Günther, Axel

“…Airway‐on‐a‐Chip In article number 2309270, Axel Günther and co‐workers present a collagen tube‐based airway model with an epithelium that is perfused with…”
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Bronchopneumonia with interstitial pneumonia in beef feedlot cattle: Characterization and laboratory investigation by Haydock, Luke A. J., Fenton, R. Kent, Sergejewich, Lauren, Veldhuizen, Ruud A. W., Smerek, Dani, Ojkic, Davor, Caswell, Jeff L.

“…Bronchopneumonia with interstitial pneumonia (BIP) has been considered a variant of acute interstitial pneumonia (AIP) rather than a distinct disease. This…”
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PepBiotics, novel cathelicidin-inspired antimicrobials to fight pulmonary bacterial infections by van Eijk, Martin, van Dijk, Albert, van der Ent, Cornelis K., Arets, Hubertus G.M., Breukink, Eefjan, van Os, Nico, Adrichem, Roy, van der Water, Sven, Lino Gómez, Rita, Kristensen, Maartje, Hessing, Martin, Jekhmane, Shehrazade, Weingarth, Markus, Veldhuizen, Ruud A.W., Veldhuizen, Edwin J.A., Haagsman, Henk P.

“…Antimicrobial peptides are considered potential alternatives to antibiotics. Here we describe the antibacterial properties of a family of novel…”
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Collagen Tubular Airway‐on‐Chip for Extended Epithelial Culture and Investigation of Ventilation Dynamics by Gao, Wuyang, Kanagarajah, Kayshani R., Graham, Emma, Soon, Kayla, Veres, Teodor, Moraes, Theo J., Bear, Christine E., Veldhuizen, Ruud A., Wong, Amy P., Günther, Axel

“…The lower respiratory tract is a hierarchical network of compliant tubular structures that are made from extracellular matrix proteins with a wall lined by an…”
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The effect of matrix metalloproteinase-3 deficiency on pulmonary surfactant in a mouse model of acute lung injury by Yamashita, Cory M, Cybulskie, Candice, Milos, Scott, Zuo, Yi Y, McCaig, Lynda A, Veldhuizen, Ruud A W

“…The acute respiratory distress syndrome (ARDS) is characterized by arterial hypoxemia accompanied by severe inflammation and alterations to the pulmonary…”
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