Search Results - "Velders, M P"

Role of alkaline phosphatase in colitis in man and rats by Tuin, A, Poelstra, K, de Jager-Krikken, A, Bok, L, Raaben, W, Velders, M P, Dijkstra, G

“…Crohn's disease (CD) and ulcerative colitis (UC) are chronic multifactorial inflammatory bowel diseases (IBDs) with unknown aetiology, but a deregulated…”
Get more information

Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells by Gabrilovich, Dmitry I, Velders, Markwin P, Sotomayor, Eduardo M, Kast, W. Martin

“…The mechanism of tumor-associated T cell dysfunction remains an unresolved problem of tumor immunology. Development of T cell defects in tumor-bearing hosts…”
Get full text

Ep-CAM: A Human Epithelial Antigen Is a Homophilic Cell-Cell Adhesion Molecule by Litvinov, Sergey V., Velders, Markwin P., Hellen A. M. Bakker, Fleuren, Gert Jan, Warnaar, Sven O.

“…The epithelial glycoprotein 40 (EGP40, also known as GA733-2, ESA, KSA, and the 17-1A antigen), encoded by the GA-733-2 gene, is expressed on the baso-lateral…”
Get full text

Defined Flanking Spacers and Enhanced Proteolysis Is Essential for Eradication of Established Tumors by an Epitope String DNA Vaccine by Velders, Markwin P, Weijzen, Sanne, Eiben, Gretchen L, Elmishad, Amira G, Kloetzel, Peter-M, Higgins, Terry, Ciccarelli, Richard B, Evans, Mererid, Man, Stephen, Smith, Larry, Kast, W. Martin

“…Loss of immunogenic epitopes by tumors has urged the development of vaccines against multiple epitopes. Recombinant DNA technologies have opened the…”
Get full text

The impact of antigen density and antibody affinity on antibody-dependent cellular cytotoxicity: relevance for immunotherapy of carcinomas by VELDERS, M. P, VAN RHIJN, C. M, OSKAM, E, FLEUREN, G. J, WARNAAR, S. O, LITVINOV, S. V

“…Antibody-dependent cellular cytotoxicity (ADCC) is considered to be the major mechanism through which tumour cells, upon treatment with anti-tumour MAbs, are…”
Get full text

Modulation of the immune response and tumor growth by activated Ras by WEIJZEN, S, VELDERS, M. P, KAST, W. M

“…As a result of its transforming abilities, activated Ras is expressed in a great number of cancers. The ras mutation frequency varies between 95% in pancreatic…”
Get full text

Prospects for immunotherapy of acute lymphoblastic leukemia by VELDERS, M. P, TER HORST, S. A. J, KAST, W. M

“…Acute lymphoblastic leukemia (ALL) is diagnosed in approximately 100000 people worldwide per year and 70% of the patients are children. Most children have a…”
Get full text

Active immunization against cancer cells: impediments and advances by Velders, M P, Schreiber, H, Kast, W M

“…Immunotherapy of cancer is still mainly an experimental treatment. Some monoclonal antibodies have been approved for adjuvant therapy of cancer in patients,…”
Get more information

Pharmacokinetic Differences Between a T Cell-Tolerizing and a T Cell-Activating Peptide by Weijzen, Sanne, Meredith, Stephen C, Velders, Markwin P, Elmishad, Amira G, Schreiber, Hans, Kast, W. Martin

“…Vaccination with a peptide representing a CTL epitope from the human papillomavirus (HPV)16 E7 protein induces a specific CTL response that prevents the…”
Get full text

Induction of HPV16 capsid protein-specific human T cell responses by virus-like particles by Rudolf, M P, Nieland, J D, DaSilva, D M, Velders, M P, Müller, M, Greenstone, H L, Schiller, J T, Kast, W M

“…It has been postulated that upon binding to a cell surface receptor, papilloma virus-like particles (VLPs) gain entry into the cytosol of infected cells and…”
Get more information

New chimeric anti-pancarcinoma monoclonal antibody with superior cytotoxicity-mediating potency by VELDERS, M. P, LITVINOV, S. V, WARNAAR, S. O, GORTER, A, FLEUREN, G. J, ZURAWSKI, V. R, CONEY, L. R

“…The monoclonal antibodies (MAbs) 323/A3 and 17-1A both recognize a 40-kDa carcinoma-associated epithelial glycoprotein (EGP40). MAb 17-1A has been used in many…”
Get full text

Eradication of established tumors by vaccination with venezuelan equine encephalitis virus replicon particles delivering human papillomavirus 16 E7 RNA by VELDERS, Markwin P, MCELHINEY, Sue, CASSETTI, Maria Cristina, EIBEN, Gretchen L, HIGGINS, Terry, KOVACS, Gerald R, ELMISHAD, Amira G, KAST, W. Martin, SMITH, Larry R

“…The etiological role of human papillomaviruses (HPV) in cervical and other cancers suggests that therapeutic vaccines directed against requisite viral antigens…”
Get full text

The Notch Ligand Jagged-1 Is Able to Induce Maturation of Monocyte-Derived Human Dendritic Cells by Weijzen, Sanne, Velders, Markwin P, Elmishad, Amira G, Bacon, Patricia E, Panella, Jeffrey R, Nickoloff, Brian J, Miele, Lucio, Kast, W. Martin

“…Notch receptors play a key role in several cellular processes including differentiation, proliferation, and apoptosis. This study investigated whether the…”
Get full text

Immunotherapy with low and high affinity monoclonal antibodies 17-1A and 323/A3 in a nude mouse xenograft carcinoma model by VELDERS, M. P, VAN RHIJN, C. M, BRIAIRE, I. H, FLEUREN, G. J, WARNAAR, S. O, LITVINOV, S. V

“…The therapeutic effects of the low and high affinity mAbs 17-1A and 323/A3 were investigated in nude mice xenografted with LS 180 human colorectal carcinoma…”
Get full text

Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen : Prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice by DAMU YANG, HOLT, Gregory E, VELDERS, Markwin P, KWON, Eugene D, KAST, W. Martin

“…To identify genes that are differentially up-regulated in prostate cancer of transgenic adenocarcinoma mouse prostate (TRAMP) mice, we subtracted cDNA isolated…”
Get full text

Establishment of an HLA-A0201 human papillomavirus type 16 tumor model to determine the efficacy of vaccination strategies in HLA-A0201 transgenic mice by EIBEN, Gretchen L, VELDERS, Markwin P, SCHREIBER, Hans, CASSETTI, Maria Cristina, PULLEN, Jeffrey K, SMITH, Larry R, KAST, W. Martin

“…With the increasing generation of new cancer vaccine strategies, there is also an increasing demand for preclinical models that can carefully predict the…”
Get full text

The role of monoclonal antibody affinity in tumor immunotherapy evaluated in in vivo models for minimal residual disease by Velders, M P, van Rhijn, C M, Cornelissen, I M, van Muijen, G N, Briaire, I H, Dohlsten, M, Fleuren, G J, Warnaar, S O, Litvinov, S V

“…To evaluate the role of affinity in monoclonal antibody (mAb)-mediated treatment of carcinomas, we compared the antibodies 17-1A and 323/A3 that bind with…”
Get more information

Physical interaction of human papillomavirus virus-like particles with immune cells by Da Silva, Diane M., Velders, Markwin P., Nieland, John D., Schiller, John T., Nickoloff, Brian J., Kast, W. Martin

“…Human papillomavirus virus-like particles (HPV VLP) and chimeric VLP are immunogens that are able to elicit potent anti-viral/tumor B and T cell responses. To…”
Get full text

Human T cell responses to endogenously presented HLA-A0201 restricted peptides of simian virus 40 large T antigen by Velders, Markwin P., Macedo, M. Fatima, Provenzano, Maurizio, Elmishad, Amira G., Holzhütter, Hermann-Georg, Carbone, Michele, Kast, W. Martin

“…Presence of the simian virus 40 (SV40) has recently been demonstrated in a relatively high percentage of human mesotheliomas and it is associated with the…”
Get full text

A Murine Model for the Effects of Pelvic Radiation and Cisplatin Chemotherapy on Human Papillomavirus Vaccine Efficacy by SMALL, Laurie A, DA SILVA, Diane M, DE VISSER, Karin E, VELDERS, Markwin P, FISHER, Susan G, POTKUL, Ronald K, KAST, W. Martin

“…Therapeutic human papillomavirus (HPV) vaccines for cervical cancer depend on a competent immune system to be effective. However, cancer patients are often…”
Get full text