Search Results - "Velden, C."

An Overview of the TROPICS NASA Earth Venture Mission by Blackwell, W. J., Braun, S., Bennartz, R., Velden, C., DeMaria, M., Atlas, R., Dunion, J., Marks, F., Rogers, R., Annane, B., Leslie, R. V.

“…The Time-Resolved Observations of Precipitation structure and storm Intensity with a Constellation of Smallsats (TROPICS) mission was selected by NASA as part…”
Get full text

Unraveling allostery within the angiotensin II type 1 receptor for Gα q and β-arrestin coupling by Cao, Yubo, van der Velden, Wijnand J C, Namkung, Yoon, Nivedha, Anita K, Cho, Aaron, Sedki, Dana, Holleran, Brian, Lee, Nicholas, Leduc, Richard, Muk, Sanychen, Le, Keith, Bhattacharya, Supriyo, Vaidehi, Nagarajan, Laporte, Stéphane A

“…G protein-coupled receptors engage both G proteins and β-arrestins, and their coupling can be biased by ligands and mutations. Here, to resolve structural…”
Get more information

Novel agonist and antagonist radioligands for the GLP‐2 receptor. Useful tools for studies of basic GLP‐2 receptor pharmacology by Gadgaard, Sarina, Velden, Wijnand J. C., Schiellerup, Sine P., Hunt, Jenna Elizabeth, Gabe, Maria B. N., Windeløv, Johanne Agerlin, Boer, Geke Aline, Kissow, Hannelouise, Ørskov, Cathrine, Holst, Jens J., Hartmann, Bolette, Rosenkilde, Mette M.

“…Background Glucagon‐like peptide‐2 (GLP‐2) is a pro‐glucagon‐derived hormone secreted from intestinal enteroendocrine L cells with actions on gut and bones…”
Get full text

The Effect of Prognostic Communication on Patient Outcomes in Palliative Cancer Care: a Systematic Review by van der Velden, Naomi C. A., Meijers, Maartje C., Han, Paul K. J., van Laarhoven, Hanneke W. M., Smets, Ellen M. A., Henselmans, Inge

“…Background While prognostic information is considered important for treatment decision-making, physicians struggle to communicate prognosis to advanced cancer…”
Get full text

Characteristics of patients with advanced cancer preferring not to know prognosis: a multicenter survey study by van der Velden, Naomi C. A, van Laarhoven, Hanneke W. M, Burgers, Sjaak A, Hendriks, Lizza E. L, de Vos, Filip Y. F. L, Dingemans, Anne-Marie C, Jansen, Joost, van Haarst, Jan-Maarten W, Dits, Joyce, Smets, Ellen MA, Henselmans, Inge

“…Abstract Background For some patients with advanced cancer not knowing prognosis is essential. Yet, in an era of informed decision-making, the potential…”
Get full text

Tone in politics is not systematically related to macro trends, ideology, or experience by Pipal, Christian, Bakker, Bert N., Schumacher, Gijs, van der Velden, Mariken A. C. G.

“…What explains the variation in tone in politics? Different literatures argue that changes in the tone of politicians reflect changes in the economy, general…”
Get full text

When is it safe to resume driving after total hip and total knee arthroplasty? a meta-analysis of literature on post-operative brake reaction times by van der Velden, C A, Tolk, J J, Janssen, R P A, Reijman, M

“…The aim of this study was to assess the current available evidence about when patients might resume driving after elective, primary total hip (THA) or total…”
Get more information

Communication about Prognosis during Patient-Initiated Second Opinion Consultations in Advanced Cancer Care: An Observational Qualitative Analysis by van der Velden, N. C. A., van der Kleij, M. B. A., Lehmann, V., Smets, E. M. A., Stouthard, J. M. L., Henselmans, I., Hillen, M. A.

“…Prognostic communication is essential for patients with advanced cancer to enable informed medical decision-making and end-of-life planning. Discussing…”
Get full text

A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor by Sun, Wen, Chen, Li-Nan, Zhou, Qingtong, Zhao, Li-Hua, Yang, Dehua, Zhang, Huibing, Cong, Zhaotong, Shen, Dan-Dan, Zhao, Fenghui, Zhou, Fulai, Cai, Xiaoqing, Chen, Yan, Zhou, Yan, Gadgaard, Sarina, van der Velden, Wijnand J. C., Zhao, Suwen, Jiang, Yi, Rosenkilde, Mette M., Xu, H. Eric, Zhang, Yan, Wang, Ming-Wei

“…Glucagon-like peptides (GLP-1 and GLP-2) are two proglucagon-derived intestinal hormones that mediate distinct physiological functions through two related…”
Get full text

Phase II to III Study Comparing Doxorubicin and Docetaxel With Fluorouracil, Doxorubicin, and Cyclophosphamide As First-Line Chemotherapy in Patients With Metastatic Breast Cancer: Results of a Dutch Community Setting Trial for the Clinical Trial Group of the Comprehensive Cancer Centre by BONTENBAL, Marijke, CREEMERS, Geert-Jan, SCHOTHORST, Kristel L, SCHMITZ, Paul I, BOKMA, Hansje J, VERWEIJ, Jaap, SEYNAEVE, Caroline, BRAUN, Hans J, DE BOER, Auke C, JANSSEN, Jos Th, LEYS, Rieneke B, RUIT, Jan B, GOEY, Swan Hoo, VAN DER VELDEN, Paul C, KERKHOFS, Lean G

“…To compare the efficacy and safety of doxorubicin and docetaxel (AT) with fluorouracil, doxorubicin, and cyclophosphamide (FAC) as first-line chemotherapy for…”
Get full text

Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long‐term impairment of the GIP system by Gabe, Maria Buur Nordskov, van der Velden, Wijnand J. C., Gadgaard, Sarina, Smit, Florent Xavier, Hartmann, Bolette, Bräuner‐Osborne, Hans, Rosenkilde, Mette Marie

“…In patients with type 2 diabetes mellitus (T2DM), the insulinotropic action of the GIP system is desensitized, whereas this is not the case for the GLP‐1…”
Get full text

Three Gaps in Computational Text Analysis Methods for Social Sciences: A Research Agenda by Baden, Christian, Pipal, Christian, Schoonvelde, Martijn, van der Velden, Mariken A. C. G

“…We identify three gaps that limit the utility and obstruct the progress of computational text analysis methods (CTAM) for social science research. First, we…”
Get full text

Identification of a conserved chemokine receptor motif that enables ligand discrimination by Larsen, Olav, van der Velden, Wijnand J C, Mavri, Maša, Schuermans, Sara, Rummel, Pia C, Karlshøj, Stefanie, Gustavsson, Martin, Proost, Paul, Våbenø, Jon, Rosenkilde, Mette M

“…Extensive ligand-receptor promiscuity in the chemokine signaling system balances beneficial redundancy and specificity. However, this feature poses a major…”
Get more information

THE IMPACT OF THE SAHARAN AIR LAYER ON ATLANTIC TROPICAL CYCLONE ACTIVITY by Dunion, Jason P., Velden, Christopher S.

“…A deep well-mixed, dry adiabatic layer forms over the Sahara Desert and Sahel regions of North Africa during the late spring, summer, and early fall. As this…”
Get full text

Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2 by Ortiz Zacarías, Natalia V, van Veldhoven, Jacobus P. D, Portner, Laura, van Spronsen, Eric, Ullo, Salviana, Veenhuizen, Margo, van der Velden, Wijnand J. C, Zweemer, Annelien J. M, Kreekel, Roy M, Oenema, Kenny, Lenselink, Eelke B, Heitman, Laura H, IJzerman, Adriaan P

“…The recent crystal structures of CC chemokine receptors 2 and 9 (CCR2 and CCR9) have provided structural evidence for an allosteric, intracellular binding…”
Get full text

Perspective: Implications of Ligand–Receptor Binding Kinetics for Therapeutic Targeting of G Protein-Coupled Receptors by van der Velden, Wijnand J. C, Heitman, Laura H, Rosenkilde, Mette M

“…The concept of ligand–receptor binding kinetics has been broadly applied in drug development pipelines focusing on G protein-coupled receptors (GPCRs). The…”
Get full text

Effects of Prognostic Communication Strategies on Prognostic Perceptions, Treatment Decisions and End-Of-Life Anticipation in Advanced Cancer: An Experimental Study among Analogue Patients by van der Velden, Naomi C.A., Smets, Ellen M.A., van Vliet, Liesbeth M., Brom, Linda, van Laarhoven, Hanneke W.M., Henselmans, Inge

“…Evidence-based guidance for oncologists on how to communicate prognosis is scarce. To investigate the effects of prognostic communication strategies…”
Get full text

Patient-Caregiver Dyads’ Prognostic Information Preferences and Perceptions in Advanced Cancer by van der Velden, Naomi C.A., Smets, Ellen M.A., Hagedoorn, Mariët, Applebaum, Allison J., Onwuteaka-Philipsen, Bregje D., van Laarhoven, Hanneke W.M., Henselmans, Inge

“…Prognostic information is considered important for advanced cancer patients and primary informal caregivers to prepare for the end of life. Little is known…”
Get full text

Use and appreciation of combined computer- and mobile-based physical activity interventions within adults aged 50 years and older: Randomized controlled trial by Collombon, Eline H G M, Bolman, Catherine A W, de Bruijn, Gert-Jan, Peels, Denise A, van der Velden, Jessie M C, Lechner, Lilian

“…To investigate whether six combined computer- and mobile-based physical activity interventions differ regarding use, attrition, usability and appreciation…”
Get full text

GLP‑1 Val8: A Biased GLP‑1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats by van der Velden, Wijnand J. C, Smit, Florent X, Christiansen, Charlotte B, Møller, Thor C, Hjortø, Gertrud M, Larsen, Olav, Schiellerup, Sine P, Bräuner-Osborne, Hans, Holst, Jens J, Hartmann, Bolette, Frimurer, Thomas M, Rosenkilde, Mette M

“…Biased ligands that selectively confer activity in one pathway over another are pharmacologically important because biased signaling may reduce on-target side…”
Get full text