Search Results - "Vela, José M."

Sigma 1 receptor as a therapeutic target for amyotrophic lateral sclerosis by Herrando‐Grabulosa, Mireia, Gaja‐Capdevila, Núria, Vela, José M., Navarro, Xavier

“…Amyotrophic lateral sclerosis (ALS) is an adult disease causing a progressive loss of upper and lower motoneurons, muscle paralysis and early death. ALS has a…”
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Directing the Crystal Packing in Triphenylphosphine Gold(I) Thiolates by Ligand Fluorination by Moreno-Alcántar, Guillermo, Turcio-García, Luis, Guevara-Vela, José M, Romero-Montalvo, Eduardo, Rocha-Rinza, Tomás, Pendás, Ángel Martín, Flores-Álamo, Marcos, Torrens, Hugo

“…We explore herein the supramolecular interactions that control the crystalline packing in a series of fluorothiolate triphenylphosphine gold­(I) compounds with…”
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Sigma‐1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury by Bravo‐Caparrós, Inmaculada, Ruiz‐Cantero, M. Carmen, Perazzoli, Gloria, Cronin, Shane J. F., Vela, José M., Hamed, Mohamed F., Penninger, Josef M., Baeyens, José M., Cobos, Enrique J., Nieto, Francisco R.

“…Neuron‐immune interaction in the dorsal root ganglia (DRG) plays a pivotal role in the neuropathic pain development after nerve injury. Sigma‐1 receptor…”
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S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund’s adjuvant models in mice by Gris, Georgia, Merlos, Manuel, Vela, José M, Zamanillo, Daniel, Portillo-Salido, Enrique

“…The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ1R) antagonist, has been explored in experimental neuropathic pain, but not in…”
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EST79232 and EST79376, Two Novel Sigma-1 Receptor Ligands, Exert Neuroprotection on Models of Motoneuron Degeneration by Gaja-Capdevila, Núria, Hernández, Neus, Yeste, Sandra, Reinoso, Raquel F, Burgueño, Javier, Montero, Ana, Merlos, Manuel, Vela, José M, Herrando-Grabulosa, Mireia, Navarro, Xavier

“…Motor neuron diseases (MNDs) include sporadic and hereditary neurological disorders characterized by progressive degeneration of motor neurons (MNs). Sigma-1…”
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Genetic Inactivation and Pharmacological Blockade of Sigma-1 Receptors Prevent Paclitaxel-Induced Sensory-Nerve Mitochondrial Abnormalities and Neuropathic Pain in Mice by Nieto, Francisco R, Cendán, Cruz M, Cañizares, Francisco J, Cubero, María A, Vela, José M, Fernández-Segura, Eduardo, Baeyens, José M

“…Background: Paclitaxel, a widely-used antineoplastic drug, produces a painful peripheral neuropathy that in rodents is associated with peripheral-nerve…”
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Pharmacological sensitivity of reflexive and nonreflexive outcomes as a correlate of the sensory and affective responses to visceral pain in mice by de la Puente, Beatriz, Zamanillo, Daniel, Romero, Luz, Vela, José M., Merlos, Manuel, Portillo-Salido, Enrique

“…Pain encompasses both sensory and affective dimensions which can be differentially modulated by drugs. Here, we compare the pharmacological sensitivity of the…”
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Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice by Tejada, Miguel A., Montilla-García, Angeles, Cronin, Shane J., Cikes, Domagoj, Sánchez-Fernández, Cristina, González-Cano, Rafael, Ruiz-Cantero, M. Carmen, Penninger, Josef M., Vela, José M., Baeyens, José M., Cobos, Enrique J.

“…Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs, so sigma-1 receptors constitute a biological brake to opioid drug-induced…”
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A new Chrysomelid-Pinaceae relationship: Calomicrus foveolatus (Coleoptera, Chrysomelidae) feeding on the Andalusian fir, Abies pinsapo (Pinaceae) in the Sierra de las Nieves National Park (Málaga, Spain) by Vela, José M., Azofra-Ruiz, Lorena, Sánchez-Callado, Francisco M.

“…Aim of study: A defoliating insect, Calomicrus foveolatus, feeding on the Andalusian endemic fir Abies pinsapo (Pinaceae) is herein reported for the first…”
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Cannabinoids Promote Oligodendrocyte Progenitor Survival: Involvement of Cannabinoid Receptors and Phosphatidylinositol-3 Kinase/Akt Signaling by Molina-Holgado, Eduardo, Vela, Jose M, Arevalo-Martin, Angel, Almazan, Guillermina, Molina-Holgado, Francisco, Borrell, Jose, Guaza, Carmen

“…Cannabinoids exert pleiotropic actions in the CNS, including the inhibition of inflammatory responses and the enhancement of neuronal survival after injury…”
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Torymus sinensis Kamijo, a biocontrol agent against the invasive chestnut gall wasp Dryocosmus kuriphilus Yasumatsu in Spain: its natural dispersal from France and the first data on establishment after experimental releases by Nieves-Aldrey, Jose Luis, Gil-Tapetado, Diego, Gavira, Oscar, Boyero, Juan R., Polidori, Carlo, Lombardero, Maria J., Blanco, Diana, Rey del castillo, Carmen, Rodriguez Rojo, Pilar, Vela, Jose M., Wong, Eva

“…Aim of study: The globally invasive gall wasp, Dryocosmus kuriphilus Yasumatsu, 1951 (Cynipidae: Cynipini), reached Spain seven years ago and is already…”
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Cyclooxygenase-independent inhibitory effects on T cell activation of novel 4,5-dihydro-3 trifluoromethyl pyrazole cyclooxygenase-2 inhibitors by Iñiguez, Miguel A., Punzón, Carmen, Cacheiro-Llaguno, Cristina, Díaz-Muñoz, Manuel D., Duque, Javier, Cuberes, Rosa, Alvarez, Inés, Andrés, Eva M., Buxens, Jordi, Buschmann, Helmut, Vela, José M., Fresno, Manuel

“…Anti-inflammatory efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) has been related to their properties as inhibitors of cyclooxygenase…”
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Inhibitory effects of sigma-2 receptor agonists on T lymphocyte activation by Iñiguez, Miguel A, Punzón, Carmen, Nieto, Raquel, Burgueño, Javier, Vela, José M, Fresno, Manuel

“…Sigma (σ) receptor ligands are essentially known for their effects on the nervous system although recent studies have shown their potential effects modulating…”
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COX-2 Inhibition Combined with Radiation Reduces Orthotopic Glioma Outgrowth by Targeting the Tumor Vasculature by Wagemakers, Michiel, van der Wal, Gesiena E., Cuberes, Rosa, Álvarez, Inés, Andrés, Eva Ma, Buxens, Jordi, Vela, José M., Moorlag, Henk, Mooij, Jan Jakob A., Molema, Grietje

“…Cyclooxygenase 2 (COX-2) inhibitors have been shown to enhance tumor's response to radiation in several animal models. The strong association of COX-2 and…”
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A Medicinal-Chemistry-Guided Approach to Selective and Druglike Sigma 1 Ligands by Corbera, Jordi, Vaño, David, Martínez, Daniel, Vela, José M., Zamanillo, Daniel, Dordal, Alberto, Andreu, Francesc, Hernandez, Enric, Perez, Raquel, Escriche, Marisol, Salgado, Leonardo, Yeste, Sandra, Serafini, Maria Teresa, Pascual, Rosalia, Alegre, Júlia, Calvet, Maria Carme, Cano, Núria, Carro, Mónica, Buschmann, Helmut, Holenz, Jörg

“…Based on a medicinal‐chemistry‐guided approach, three novel series of druglike cycloalkyl‐annelated pyrazoles were synthesized and display high affinity (pKi…”
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The Relationship Between Metabolic Syndrome and Benign Prostate Enlargement: A Case–Control Study in a Peruvian Military Hospital by Ugarte-Carbajal, Valeria, Vela-Ruiz, José M, Guillen-Ponce, Vela-Rui, Correa-López, Lucy E, Rubin-de-Celis, Verónica, Jhony A. De La Cruz-Vargas

“…Objective: This study aimed to determine how metabolic syndrome is related to benign prostatic enlargement in males under 60 years old in a national military…”
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Niveles elevados de fibrinógeno en el sujeto delgado metabólicamente obeso: un estudio transversal analítico a partir de una muestra de pobladores peruanos by Victor Juan Vera-Ponce, Gianella Zulema Zeñas-Trujillo, Jenny Raquel Torres-Malca, Liliana Cruz-Ausejo, Mario J. Valladares-Garrido, Jesus Enrique Talavera Ramirez, Jose M Vela-Ruiz, Jhony A. De la Cruz Vargas

“…Introducción: El fibrinógeno plasmático, es reconocido como un factor de riesgo importante para eventos cardiometabólicos a través de mecanismos como la…”
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Inter-organizational Cooperation and Environmental Change: Moderating Effects between Flexibility and Innovation Performance by Martínez-Sánchez, Angel, Vela-Jiménez, M. José, Pérez-Pérez, Manuela, De-Luis-Carnicer, Pilar

“…The paper investigates the moderator effect of inter‐organizational cooperation in the relationship between workplace flexibility and innovation performance…”
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Interleukin-1 Regulates Proliferation and Differentiation of Oligodendrocyte Progenitor Cells by Vela, José M., Molina-Holgado, Eduardo, Arévalo-Martı́n, Ángel, Almazán, Guillermina, Guaza, Carmen

“…Interleukin-1 (IL-1) is a pleiotropic cytokine expressed during normal CNS development and in inflammatory demyelinating diseases, but remarkably little is…”
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Gaps in access to oncological treatment in a reference health hospital in the south of Lima in 2019 by Bustamante, Reina I., Vela- Ruiz, José M., Paredes-Olivares, Omar, Carreño-Escobedo, Ricardo A.

“…Introduction: Cancer, a chronic disease that has a high incidence with 14.1 million people and more than 8.1 million deaths, generating a large access gap…”
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