Search Results - "Vela, Jennifer E."

Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides by Arnold, Jamie J, Sharma, Suresh D, Feng, Joy Y, Ray, Adrian S, Smidansky, Eric D, Kireeva, Maria L, Cho, Aesop, Perry, Jason, Vela, Jennifer E, Park, Yeojin, Xu, Yili, Tian, Yang, Babusis, Darius, Barauskus, Ona, Peterson, Blake R, Gnatt, Averell, Kashlev, Mikhail, Zhong, Weidong, Cameron, Craig E

“…Ribonucleoside analogues have potential utility as anti-viral, -parasitic, -bacterial and -cancer agents. However, their clinical applications have been…”
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Mechanism of Active Renal Tubular Efflux of Tenofovir by RAY, Adrian S, CIHLAR, Tomas, ROBINSON, Kelly L, TONG, Leah, VELA, Jennifer E, FULLER, Michael D, WIEMAN, Lani M, EISENBERG, Eugene J, RHODES, Gerry R

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Design and Profiling of GS-9148, a Novel Nucleotide Analog Active against Nucleoside-Resistant Variants of Human Immunodeficiency Virus Type 1, and Its Orally Bioavailable Phosphonoamidate Prodrug, GS-9131 by Cihlar, Tomas, Ray, Adrian S, Boojamra, Constantine G, Zhang, Lijun, Hui, Hon, Laflamme, Genevieve, Vela, Jennifer E, Grant, Deborah, Chen, James, Myrick, Florence, White, Kirsten L, Gao, Ying, Lin, Kuei-Ying, Douglas, Janet L, Parkin, Neil T, Carey, Anne, Pakdaman, Rowchanak, Mackman, Richard L

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Novel Nucleotide Human Immunodeficiency Virus Reverse Transcriptase Inhibitor GS-9148 with a Low Nephrotoxic Potential: Characterization of Renal Transport and Accumulation by CIHLAR, Tomas, LAFLAMME, Genevieve, FISHER, Robyn, CAREY, Anne C, VELA, Jennifer E, MACKMAN, Richard, RAY, Adrian S

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Simultaneous quantitation of the nucleotide analog adefovir, its phosphorylated anabolites and 2′-deoxyadenosine triphosphate by ion-pairing LC/MS/MS by Vela, Jennifer E., Olson, Loren Y., Huang, Alan, Fridland, Arnold, Ray, Adrian S.

“…The nucleotide analog adefovir is an important therapy for hepatitis B viral infection. The study of nucleoside/tide pharmacology has been hampered by…”
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Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148 by Mackman, Richard L., Ray, Adrian S., Hui, Hon C., Zhang, Lijun, Birkus, Gabriel, Boojamra, Constantine G., Desai, Manoj C., Douglas, Janet L., Gao, Ying, Grant, Deborah, Laflamme, Genevieve, Lin, Kuei-Ying, Markevitch, David Y., Mishra, Ruchika, McDermott, Martin, Pakdaman, Rowchanak, Petrakovsky, Oleg V., Vela, Jennifer E., Cihlar, Tomas

“…GS-9148 [(5-(6-amino-purin-9-yl)-4-fluoro-2,5-dihydro-furan-2-yloxymethyl)phosphonic acid] 4 is a novel nucleoside phosphonate HIV-1 reverse transcriptase (RT)…”
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Intracellular Metabolism of the Nucleotide Prodrug GS-9131, a Potent Anti-Human Immunodeficiency Virus Agent by RAY, Adrian S, VELA, Jennifer E, CIHLAR, Tomas, BOOJAMRA, Constantine G, LIJUN ZHANG, HUI, Hon, CALLEBAUT, Christian, STRAY, Kirsten, LIN, Kuei-Ying, YING GAO, MACKMAN, Richard L

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Design, synthesis, and anti-HIV activity of 4′-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors by Boojamra, Constantine G., Parrish, Jay P., Sperandio, David, Gao, Ying, Petrakovsky, Oleg V., Lee, Sharon K., Markevitch, David Y., Vela, Jennifer E., Laflamme, Genevieve, Chen, James M., Ray, Adrian S., Barron, Abraham C., Sparacino, Mark L., Desai, Manoj C., Kim, Choung U., Cihlar, Tomas, Mackman, Richard L.

“…A series of 4′-modified carbocyclic nucleoside phosphonates were synthesized and found to be potent submicromolar inhibitors of HIV reverse transcriptase. A…”
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Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides by Cho, Aesop, Saunders, Oliver L., Butler, Thomas, Zhang, Lijun, Xu, Jie, Vela, Jennifer E., Feng, Joy Y., Ray, Adrian S., Kim, Choung U.

“…A series of 1′-substituted analogs of 4-aza-7,9-dideazaadenosine C-nucleoside were prepared and evaluated for the potential as antiviral agents. These…”
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Effective metabolism and long intracellular half life of the anti-Hepatitis B agent adefovir in hepatic cells by Ray, Adrian S., Vela, Jennifer E., Olson, Loren, Fridland, Arnold

“…Adefovir dipivoxil (ADV) is esterolytically cleaved to the 2′-deoxyadenosine monophosphate (dAMP) analog adefovir, subsequent phosphorylation leads to the…”
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Metabolism and Pharmacokinetics of the Anti-Hepatitis C Virus Nucleotide Prodrug GS-6620 by MURAKAMI, Eisuke, TING WANG, KIM, Choung U, AESOP CHO, RAY, Adrian S, BABUSIS, Darius, LEPIST, Eve-Irene, SAUER, Dorothea, YEOJIN PARK, VELA, Jennifer E, SHIH, Robert, BIRKUS, Gabriel, STEFANIDIS, Dimitrios

“…The anti-hepatitis C virus nucleotide prodrug GS-6620 employs a double-prodrug approach, with l-alanine-isopropyl ester and phenol moieties attached to the…”
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Molecular assessment of the potential for renal drug interactions between tenofovir and HIV protease inhibitors by CIHLAR, Tomas, RAY, Adrian S, LAFLAMME, Genevieve, VELA, Jennifer E, TONG, Leah, FULLER, Michael D, ROY, Anupma, RHODES, Gerald R

“…Active renal secretion of tenofovir (TFV) across proximal tubules occurs via uptake by human organic anion transporters 1 and 3 (hOAT1 and hOAT3) coupled with…”
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Nucleotide Analogue Prodrug Tenofovir Disoproxil Enhances Lymphoid Cell Loading following Oral Administration in Monkeys by Durand-Gasselin, Lucie, Van Rompay, Koen K. A, Vela, Jennifer E, Henne, Ilana N, Lee, William A, Rhodes, Gerry R, Ray, Adrian S

“…The antiviral drug tenofovir (TFV) is orally administered as the fumarate salt of its disoproxil prodrug (TFV disoproxil fumarate (TDF)). TFV is a dianion at…”
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In vitro evaluation of the anti-HIV activity and metabolic interactions of tenofovir and emtricitabine by BORROTO-ESODA, Katyna, VELA, Jennifer E, MYRICK, Florence, RAY, Adrian S, MILLER, Michael D

“…Tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) are nucleoside reverse transcriptase inhibitors (NRTIs) with once-daily dosing approved for use in…”
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Effect of nucleoside and nucleotide reverse transcriptase inhibitors of HIV on endogenous nucleotide pools by VELA, Jennifer E, MILLER, Michael D, RHODES, Gerald R, RAY, Adrian S

“…Alterations in endogenous nucleotide pools as a result of HIV therapy with nucleoside and nucleotide reverse transcriptase inhibitors (N[t]RTIs) is a proposed…”
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Lack of a metabolic and antiviral drug interaction between tenofovir, abacavir and lamivudine by RAY, Adrian S, MYRICK, Florence, VELA, Jennifer E, OLSON, Loren Y, EISENBERG, Eugene J, BORROTO-ESODA, Katyna, MILLER, Michael D, FRIDLAND, Arnold

“…An anti-HIV regimen composed of the nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) tenofovir (TFV) disoproxil fumarate (TDF), abacavir (ABC)…”
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Synthesis and antiviral activity of a series of 1a2-substituted 4-aza-7,9-dideazaadenosine C-nucleosides by Cho, Aesop, Saunders, Oliver L, Butler, Thomas, Zhang, Lijun, Xu, Jie, Vela, Jennifer E, Feng, Joy Y, Ray, Adrian S, Kim, Choung U

“…A series of 1a2-substituted analogs of 4-aza-7,9-dideazaadenosine C-nucleoside were prepared and evaluated for the potential as antiviral agents. These…”
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