Search Results - "Vekich, John A."

Mesencephalic Astrocyte-derived Neurotrophic Factor Protects the Heart from Ischemic Damage and Is Selectively Secreted upon Sarco/endoplasmic Reticulum Calcium Depletion by Glembotski, Christopher C., Thuerauf, Donna J., Huang, Chengqun, Vekich, John A., Gottlieb, Roberta A., Doroudgar, Shirin

“…Background: Intra- and extracellular MANF are protective; however, the conditions governing MANF secretion are unknown. Results: Of the conditions examined,…”
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Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages by Visentin, Barbara, Vekich, John A., Sibbald, Bradley J., Cavalli, Amy L., Moreno, Kelli M., Matteo, Rosalia G., Garland, William A., Lu, Yiling, Yu, Shuangxing, Hall, Hassan S., Kundra, Vikas, Mills, Gordon B., Sabbadini, Roger A.

“…S1P has been proposed to contribute to cancer progression by regulating tumor proliferation, invasion, and angiogenesis. We developed a biospecific monoclonal…”
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Protein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death by Vekich, John A, Belmont, Peter J, Thuerauf, Donna J, Glembotski, Christopher C

“…Abstract Proper folding of secreted and transmembrane proteins made in the rough endoplasmic reticulum (ER) requires oxygen for disulfide bond formation…”
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Balanced Activation of Striatal Output Pathways by Faster Off-Rate PDE10A Inhibitors Elicits Not Only Antipsychotic-Like Effects But Also Procognitive Effects in Rodents by Harada, Akina, Kaushal, Nidhi, Suzuki, Kazunori, Nakatani, Atsushi, Bobkov, Konstantin, Vekich, John A, Doyle, Joseph P, Kimura, Haruhide

“…Faster off-rate competitive enzyme inhibitors are generally more sensitive than slower off-rate ones to binding inhibition by enzyme substrates. We previously…”
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