Search Results - "Vehkavaara, S."

Overproduction of large VLDL particles is driven by increased liver fat content in man by Adiels, M, Taskinen, M.-R, Packard, C, Caslake, M. J, Soro-Paavonen, A, Westerbacka, J, Vehkavaara, S, Häkkinen, A, Olofsson, S.-O, Yki-Järvinen, H, Borén, J

“…Aims/hypothesis We determined whether hepatic fat content and plasma adiponectin concentration regulate VLDL₁ production. Methods A multicompartment model was…”
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Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk by WESTERBACKA, J, CORNER, A, TIIKKAINEN, M, TAMMINEN, M, VEHKAVAARA, S, HÄKKINEN, A.-M, FREDRIKSSON, J, YKI-JÄRVINEN, H

“…Fat accumulation in the liver has been shown to be closely correlated with hepatic insulin resistance and features of insulin resistance, also independently of…”
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Acute suppression of VLDL₁ secretion rate by insulin is associated with hepatic fat content and insulin resistance by Adiels, M, Westerbacka, J, Soro-Paavonen, A, Häkkinen, A. M, Vehkavaara, S, Caslake, M. J, Packard, C, Olofsson, S. O, Yki-Järvinen, H, Taskinen, M. R, Borén, J

“…Aims/hypothesis Overproduction of VLDL₁ seems to be the central pathophysiological feature of the dyslipidaemia associated with type 2 diabetes. We explored…”
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Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients by Ryysy, L, Häkkinen, A M, Goto, T, Vehkavaara, S, Westerbacka, J, Halavaara, J, Yki-Järvinen, H

“…Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements…”
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Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women by Vehkavaara, S, Silveira, A, Hakala-Ala-Pietilä, T, Virkamäki, A, Hovatta, O, Hamsten, A, Taskinen, M R, Yki-Järvinen, H

“…We compared the effects of oral estradiol (2 mg), transdermal estradiol (50 microg), and placebo on measures of coagulation, fibrinolysis, inflammation and…”
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Obesity is associated with impaired platelet-inhibitory effect of acetylsalicylic acid in nondiabetic subjects by Tamminen, M, Lassila, R, Westerbacka, J, Vehkavaara, S, Yki-Järvinen, H

“…OBJECTIVE: Platelet aggregation responses to acetylsalicylic acid (ASA) show considerable interindividual variation, the causes of which are largely unknown…”
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Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity by WESTERBACKA, J, VEHKAVAARA, S, BERGHOLM, R, WILKINSON, I, COCKCROFT, J, YKI-JÄRVINEN, H

“…Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity. J Westerbacka , S Vehkavaara , R Bergholm , I Wilkinson…”
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Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women by VEHKAVAARA, Satu, HAKALA-ALA-PIETILÄ, Tiina, VIRKAMÄKI, Antti, BERGHOLM, Robert, EHNHOLM, Christian, HOVATTA, Outi, TASKINEN, Marja-Riitta, YKI-JÄRVINEN, Hannele

“…We determined whether the vascular effects of estradiol depend on the route of administration by comparing the effects of oral estradiol and transdermal…”
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In vivo endothelial dysfunction characterizes patients with impaired fasting glucose by VEHKAVAARA, S, SEPPALA-LINDROOS, A, WESTERBACKA, J, GROOP, P.-H, YKI-JARVINEN, H

“…In vivo endothelial dysfunction characterizes patients with impaired fasting glucose. S Vehkavaara , A Seppälä-Lindroos , J Westerbacka , P H Groop and H…”
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Insulin therapy improves insulin actions on glucose metabolism and aortic wave reflection in type 2 diabetic patients by Tamminen, M. K., Westerbacka, J., Vehkavaara, S., Yki-Järvinen, H.

“…Background  Normal insulin action in vivo involves a decrease in aortic systolic blood pressure as a result of an insulin‐induced decrease in the amplitude of…”
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Insulin sensitivity regulates autonomic control of heart rate variation independent of body weight in normal subjects by BERGHOLM, R, WESTERBACKA, J, VEHKAVAARA, S, SEPPÄLÄ-LINDROOS, A, GOTO, T, YKI-JÄRVINEN, H

“…It is unclear whether insulin sensitivity independent of body weight regulates control of heart rate variation (HRV) by the autonomic nervous system. Insulin…”
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Effect of estrogen replacement therapy on insulin sensitivity of glucose metabolism and preresistance and resistance vessel function in healthy postmenopausal women by VEHKAVAARA, Satu, WESTERBACKA, Jukka, HAKALA-ALA-PIETILÄ, Tiina, VIRKAMAKI, Antti, HOVATTA, Outi, YKI-JÄRVINEN, Hannele

“…In the present study, we hypothesized that estradiol, via its ability to vasodilate in an endothelium-dependent manner, might enhance vascular effects of…”
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Physiologic doses of insulin decrease central systolic blood pressure without changing peripheral vascular resistance in normal subjects by Vehkavaara, S., Westerbacka, J., Yki-Järvinen, H.

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Insulin Sensitivity Regulates Autonomic Control of Heart Rate Variation Independent of Body Weight in Normal Subjects1 by Bergholm, R., Westerbacka, J., Vehkavaara, S., Seppälä-Lindroos, A., Goto, T., Yki-Järvinen, H.

“…It is unclear whether insulin sensitivity independent of body weight regulates control of heart rate variation (HRV) by the autonomic nervous system. Insulin…”
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Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men by SEPPÄLÄ-LINDROOS, Anneli, VEHKAVAARA, Satu, HÄKKINEN, Anna-Maija, GOTO, Takashi, WESTERBACKA, Jukka, SOVIJÄRVI, Anssi, HALAVAARA, Juha, YKI-JÄRVINEN, Hannele

“…We determined whether interindividual variation in hepatic insulin sensitivity could be attributed to variation in liver fat content (LFAT) independent of…”
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Effects of Identical Weight Loss on Body Composition and Features of Insulin Resistance in Obese Women With High and Low Liver Fat Content by TIIKKAINEN, Mirja, BERGHOLM, Robert, VEHKAVAARA, Satu, RISSANEN, Aila, HÄKKINEN, Anna-Maija, TAMMINEN, Marjo, TERAMO, Kari, YKI-JÄRVINEN, Hannele

“…Effects of Identical Weight Loss on Body Composition and Features of Insulin Resistance in Obese Women With High and Low Liver Fat Content Mirja Tiikkainen 1 ,…”
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3.5 Years of Insulin Therapy With Insulin Glargine Improves In Vivo Endothelial Function in Type 2 Diabetes by Vehkavaara, Satu, Yki-Järvinen, Hannele

“…OBJECTIVE—To determine long-term effects of insulin glargine on vascular function in patients with type 2 diabetes. METHODS AND RESULTS—A total of 49 in vivo…”
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Impaired responsiveness to NO in newly diagnosed patients with rheumatoid arthritis by BERGHOLM, Robert, LEIRISALO-REPO, Marjatta, VEHKAVAARA, Satu, MÄKIMATTILA, Sari, TASKINEN, Marja-Riitta, YKI-JÄRVINEN, Hannele

“…Cardiovascular disease is the major cause of excessive mortality in patients with rheumatoid arthritis (RA). We determined whether endothelial dysfunction…”
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Body Fat Distribution and Cortisol Metabolism in Healthy Men: Enhanced 5β-Reductase and Lower Cortisol/Cortisone Metabolite Ratios in Men with Fatty Liver by Westerbacka, Jukka, Yki-Järvinen, Hannele, Vehkavaara, Satu, Häkkinen, Anna-Maija, Andrew, Ruth, Wake, Deborah J., Seckl, Jonathan R., Walker, Brian R.

“…In Cushing’s syndrome, cortisol causes fat accumulation in specific sites most likely to be associated with insulin resistance, notably in omental adipose and…”
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Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy by SUTINEN, Jussi, HÄKKINEN, Anna-Maija, WESTERBACKA, Jukka, SEPPÄLÄ-LINDROOS, Anneli, VEHKAVAARA, Satu, HALAVAARA, Juha, JÄRVINEN, Asko, RISTOLA, Matti, YKI-JÄRVINEN, Hannele

“…To determine liver fat content in patients with highly active antiretroviral therapy (HAART)-associated lipodystrophy. Lipodystrophy in several animal models…”
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