Search Results - "Vega, Mario I."

Roles and Regulation of BCL-xL in Hematological Malignancies by Morales-Martínez, Mario, Vega, Mario I

“…Members of the Bcl-2 family are proteins that play an essential role in the regulation of apoptosis, a crucial process in development and normal physiology in…”
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Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology by Morales-Martínez, Mario, Vega, Mario I.

“…miRNAs are non-coding RNA sequences of approximately 22 nucleotides that interact with genes by inhibiting their translation through binding to their 3′ or 5′…”
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Sulforaphane induces differential modulation of mitochondrial biogenesis and dynamics in normal cells and tumor cells by Negrette-Guzmán, Mario, Huerta-Yepez, Sara, Vega, Mario I., León-Contreras, Juan Carlos, Hernández-Pando, Rogelio, Medina-Campos, Omar Noel, Rodríguez, Esteban, Tapia, Edilia, Pedraza-Chaverri, José

“…Antioxidant-based chemotherapy has been intensely debated. Herein, we show that sulforaphane (SFN) induced mitochondrial biogenesis followed by mitochondrial…”
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Role of Yin Yang-1 (YY1) in the transcription regulation of the multi-drug resistance (MDR1) gene by Antonio-Andrés, Gabriela, Rangel-Santiago, Jesus, Tirado-Rodríguez, Belen, Martinez-Ruiz, Gustavo U., Klunder-Klunder, Miguel, Vega, Mario I., Lopez-Martinez, Briceida, Jiménez-Hernández, Elva, Torres Nava, Jose, Medina-Sanson, Aurora, Huerta-Yepez, Sara

“…Resistance to chemotherapy hinders the successful treatment of acute lymphoblastic leukemia (ALL). The multi-drug resistance-1 (MDR1/ABCB1) gene encodes…”
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MicroRNA-7 Regulates Migration and Chemoresistance in Non-Hodgkin Lymphoma Cells Through Regulation of KLF4 and YY1 by Morales-Martinez, Mario, Vega, Gabriel G., Neri, Natividad, Nambo, M. J, Alvarado, Isabel, Cuadra, Ivonne, Duran-Padilla, M. A., Huerta-Yepez, Sara, Vega, Mario I.

“…The discovery and description of the role of microRNAs has become very important, specifically due to their participation in the regulation of proteins and…”
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Novel therapeutic applications of nitric oxide donors in cancer: Roles in chemo- and immunosensitization to apoptosis and inhibition of metastases by Bonavida, Benjamin, Baritaki, Stavroula, Huerta-Yepez, Sara, Vega, Mario I., Chatterjee, Devasis, Yeung, Kam

“…The treatment of primary tumors results in an initial response to approved conventional therapeutics. However, recurrences and malignancies develop as a result…”
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Inhibition of the Raf-MEK1/2-ERK1/2 signaling pathway, Bcl-xL down-regulation, and chemosensitization of non-Hodgkin's lymphoma B cells by Rituximab by Jazirehi, Ali R, Vega, Mario I, Chatterjee, Devasis, Goodglick, Lee, Bonavida, Benjamin

“…Rituximab (Rituxan, IDEC-C2B8) has been shown to sensitize non-Hodgkin's lymphoma (NHL) cell lines to chemotherapeutic drug-induced apoptosis. Rituximab…”
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Rituximab-Mediated Cell Signaling and Chemo/Immuno-sensitization of Drug-Resistant B-NHL Is Independent of Its Fc Functions by Vega, Mario I., Huerta-Yepez, Sara, Martinez-Paniagua, Melisa, Martinez-Miguel, Bernardo, Hernandez-Pando, Rogelio, González-Bonilla, Cesar R., Chinn, Paul, Hanna, Nabil, Hariharan, Kandasamy, Jazirehi, Ali R., Bonavida, Benjamin

“…Purpose: Rituximab [chimeric anti-CD20 monoclonal antibody], alone or combined with chemotherapy, is used in the treatment of non–Hodgkin's lymphoma (NHL)…”
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Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax (GX15-070) contribute in the sensitization of B-NHL cells to TRAIL apoptosis by Martínez-Paniagua, Melisa A., Baritaki, Stavroula, Huerta-Yepez, Sara, Ortiz-Navarrete, Vianney F., González-Bonilla, Cesar, Bonavida, Benjamin, Vega, Mario I.

“…The pan Bcl-2 family antagonist Obatoclax (GX15-070), currently in clinical trials, was shown to sensitize TRAIL-resistant tumors to TRAIL-mediated apoptosis…”
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Rituximab (chimeric anti-CD20) sensitizes B-NHL cell lines to Fas-induced apoptosis by VEGA, Mario I, HUERTA-YEPEZ, Sara, JAZIREHI, Ali R, GARBAN, Hermes, BONAVIDA, Benjamin

“…Rituximab (chimeric anti-CD20 monoclonal antibodies) is currently being used in the treatment of B non-Hodgkin's lymphoma (NHL). We have recently reported that…”
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Rituximab inhibits p38 MAPK activity in 2F7 B NHL and decreases IL-10 transcription: Pivotal role of p38 MAPK in drug resistance by VEGA, Mario I, HUERTA-YEPAZ, Sara, GARBAN, Hermes, JAZIREHI, Ali, EMMANOUILIDES, Christos, BONAVIDA, Benjamin

“…We have recently reported that Rituximab (anti-CD20) sensitizes drug-resistant 2F7 and 10C9 B Non-Hodgkin's lymphoma (NHL) cell lines to the apoptotic effects…”
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HIF-1 expression is associated with CCL2 chemokine expression in airway inflammatory cells: implications in allergic airway inflammation by Baay-Guzman, Guillermina J, Bebenek, Ilona G, Zeidler, Michelle, Hernandez-Pando, Rogelio, Vega, Mario I, Garcia-Zepeda, Eduardo A, Antonio-Andres, Gabriela, Bonavida, Benjamin, Riedl, Marc, Kleerup, Eric, Tashkin, Donald P, Hankinson, Oliver, Huerta-Yepez, Sara

“…The pathogenesis of allergic airway inflammation in asthmatic patients is complex and characterized by cellular infiltrates and activity of many cytokines and…”
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Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival by Huerta-Yepez, Sara, Yoon, Nam K, Hernandez-Cueto, Angeles, Mah, Vei, Rivera-Pazos, Clara M, Chatterjee, Devasis, Vega, Mario I, Maresh, Erin L, Horvath, Steve, Chia, David, Bonavida, Benjamin, Goodglick, Lee

“…Raf-1 kinase inhibitor protein (RKIP) has been reported to negatively regulate signal kinases of major survival pathways. RKIP activity is modulated in part by…”
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p38 Molecular Targeting for Next-Generation Multiple Myeloma Therapy by Morales-Martínez, Mario, Vega, Mario I

“…Resistance to therapy and disease progression are the main causes of mortality in most cancers. In particular, the development of resistance is an important…”
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Function of Deptor and its roles in hematological malignancies by Morales-Martinez, Mario, Lichtenstein, Alan, Vega, Mario I

“…Deptor is a protein that interacts with mTOR and that belongs to the mTORC1 and mTORC2 complexes. Deptor is capable of inhibiting the kinase activity of mTOR…”
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KLF4 inhibition by Kenpaullone induces cytotoxicity and chemo sensitization in B-NHL cell lines via YY1 independent by Montecillo-Aguado, Mayra, Morales-Martínez, Mario, Huerta-Yepez, Sara, Vega, Mario I.

“…Krüppel-like factor 4 (KLF4) is a member of the KLF transcription factor family containing zinc-fingers, and is involved in the regulation of apoptosis,…”
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Development of rituximab-resistant lymphoma clones with altered cell signaling and cross-resistance to chemotherapy by JAZIREHI, Ali R, VEGA, Mario I, BONAVIDA, Benjamin

“…Immunotherapy with rituximab (chimeric anti-CD20 monoclonal antibody, Rituxan), alone or in conjunction with chemotherapy, has significantly improved the…”
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A Novel Therapeutic Induces DEPTOR Degradation in Multiple Myeloma Cells with Resulting Tumor Cytotoxicity by Vega, Mario I, Shi, Yijiang, Frost, Patrick, Huerta-Yepez, Sara, Antonio-Andres, Gabriela, Hernandez-Pando, Rogelio, Lee, Jihye, Jung, Michael E, Gera, Joseph F, Lichtenstein, Alan

“…Prior work indicates DEPTOR expression in multiple myeloma cells could be a therapeutic target. DEPTOR binds to mTOR via its PDZ domain and inhibits mTOR…”
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Contribution of either YY1 or BclXL-induced inhibition by the NO-donor DETANONOate in the reversal of drug resistance, both in vitro and in vivo. YY1 and BclXL are overexpressed in prostate cancer by Huerta-Yepez, Sara, Baritaki, Stavroula, Baay-Guzman, Guillermina, Hernandez-Luna, Marco A., Hernandez-Cueto, Angeles, Vega, Mario I., Bonavida, Benjamin

“…► We analyzed the chemosensitizing activity and mechanism of action of nitric oxide. ► We identified at YY1 and BclXL in PCa that regulate resistance and are…”
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Cytotoxic effect caspase activation dependent of a genetically engineered fusion protein with a CD154 peptide mimetic (OmpC-CD154p) on B-NHL cell lines is mediated by the inhibition of bcl-6 and YY1 through MAPK p38 activation by Pantoja-Escobar, Gerardo, Morales-Martínez, Mario, Vega, Gabriel G., Castro-Escarpulli, Graciela, Vega, Mario I.

“…The interaction between CD40, and its ligand, CD154, is essential for the development of humoral and cellular immune responses. The selective inhibition or…”
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