Search Results - "Vega, Jerel"

Systemic delivery of factor IX messenger RNA for protein replacement therapy by Ramaswamy, Suvasini, Tonnu, Nina, Tachikawa, Kiyoshi, Limphong, Pattraranee, Vega, Jerel B., Karmali, Priya P., Chivukula, Pad, Verma, Inder M.

“…Safe and efficient delivery of messenger RNAs for protein replacement therapies offers great promise but remains challenging. In this report, we demonstrate…”
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Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir by Pardons, Marion, Cole, Basiel, Lambrechts, Laurens, van Snippenberg, Willem, Rutsaert, Sofie, Noppe, Ytse, De Langhe, Nele, Dhondt, Annemieke, Vega, Jerel, Eyassu, Filmon, Nijs, Erik, Van Gulck, Ellen, Boden, Daniel, Vandekerckhove, Linos

“…The development of latency reversing agents that potently reactivate HIV without inducing global T cell activation would benefit the field of HIV reservoir…”
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Lipid Nanoparticle Formulation Increases Efficiency of DNA-Vectored Vaccines/Immunoprophylaxis in Animals Including Transchromosomic Bovines by Mucker, Eric M., Karmali, Priya P., Vega, Jerel, Kwilas, Steven A., Wu, Hua, Joselyn, Matthew, Ballantyne, John, Sampey, Darryl, Mukthavaram, Rajesh, Sullivan, Eddie, Chivukula, Pad, Hooper, Jay W.

“…The use of nucleic acid as a drug substance for vaccines and other gene-based medicines continues to evolve. Here, we have used a technology originally…”
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Anti-HFRS Human IgG Produced in Transchromosomic Bovines Has Potent Hantavirus Neutralizing Activity and Is Protective in Animal Models by Perley, Casey C., Brocato, Rebecca L., Wu, Hua, Bausch, Christoph, Karmali, Priya P., Vega, Jerel B., Cohen, Melanie V., Somerville, Brandon, Kwilas, Steven A., Principe, Lucia M., Shamblin, Joshua, Chivukula, Padmanabh, Sullivan, Eddie, Hooper, Jay W.

“…We explored an emerging technology to produce anti-Hantaan virus (HTNV) and anti-Puumala virus (PUUV) neutralizing antibodies for use as pre- or post-exposure…”
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Development of an mRNA replacement therapy for phenylketonuria by Perez-Garcia, Carlos G., Diaz-Trelles, Ramon, Vega, Jerel Boyd, Bao, Yanjie, Sablad, Marciano, Limphong, Patty, Chikamatsu, Simon, Yu, Hailong, Taylor, Wendy, Karmali, Priya P., Tachikawa, Kiyoshi, Chivukula, Padmanabh

“…Phenylketonuria (PKU) is an inborn error caused by deficiencies in phenylalanine (Phe) metabolism. Mutations in the phenylalanine hydroxylase (PAH) gene are…”
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Lipid nanoparticle delivers phenylalanine ammonia lyase mRNA to the liver leading to catabolism and clearance of phenylalanine in a phenylketonuria mouse model by Diaz-Trelles, Ramon, Lee, Sharon, Kuakini, Kristen, Park, Jenny, Dukanovic, Adrian, Gonzalez, Jose A., Dam, Thanhchau, Kim, Jae Heon, Vega, Jerel Boyd, Sablad, Marciano, Karmali, Priya P., Tachikawa, Kiyoshi, Chivukula, Padmanabh

“…Phenylketonuria (PKU) is a genetic disorder affecting around 1 in 12,000 live births (1), caused by a mutation in the phenylalanine hydroxylase (PAH) gene in…”
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A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice by de Alwis, Ruklanthi, Gan, Esther S., Chen, Shiwei, Leong, Yan Shan, Tan, Hwee Cheng, Zhang, Summer L., Yau, Clement, Low, Jenny G.H., Kalimuddin, Shirin, Matsuda, Daiki, Allen, Elizabeth C., Hartman, Paula, Park, Kyoung-Joo Jenny, Alayyoubi, Maher, Bhaskaran, Hari, Dukanovic, Adrian, Bao, Yanjie, Clemente, Brenda, Vega, Jerel, Roberts, Scott, Gonzalez, Jose A., Sablad, Marciano, Yelin, Rodrigo, Taylor, Wendy, Tachikawa, Kiyoshi, Parker, Suezanne, Karmali, Priya, Davis, Jared, Sullivan, Brian M., Sullivan, Sean M., Hughes, Steve G., Chivukula, Pad, Ooi, Eng Eong

“…A self-transcribing and replicating RNA (STARR)-based vaccine (LUNAR-COV19) has been developed to prevent SARS-CoV-2 infection. The vaccine encodes an…”
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Nanoparticle delivery of Tat synergizes with classical latency reversal agents to express HIV antigen targets by Raines, Samuel L M, Falcinelli, Shane D, Peterson, Jackson J, Van Gulck, Ellen, Allard, Brigitte, Kirchherr, Jennifer, Vega, Jerel, Najera, Isabel, Boden, Daniel, Archin, Nancie M, Margolis, David M

“…Limited cellular levels of the HIV transcriptional activator Tat are one contributor to proviral latency that might be targeted in HIV cure strategies. We…”
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A truncated HIV Tat demonstrates potent and specific latency reversal activity by Van Gulck, Ellen, Pardons, Marion, Nijs, Erik, Verheyen, Nick, Dockx, Koen, Van Den Eynde, Christel, Battivelli, Emilie, Vega, Jerel, Florence, Eric, Autran, Brigitte, Archin, Nancie M, Margolis, David M, Katlama, Christine, Hamimi, Chiraz, Van Den Wyngaert, Ilse, Eyassu, Filmon, Vandekerckhove, Linos, Boden, Daniel

“…A major barrier to HIV-1 cure is caused by the pool of latently infected CD4 T-cells that persist under combination antiretroviral therapy (cART). This latent…”
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CD8 + T cells mediate protection against Zika virus induced by an NS3-based vaccine by Elong Ngono, Annie, Syed, Thasneem, Nguyen, Anh-Viet, Regla-Nava, Jose Angel, Susantono, Mercylia, Spasova, Darina, Aguilar, Allison, West, Melissa, Sparks, Jessica, Gonzalez, Andrew, Branche, Emilie, DeHart, Jason L, Vega, Jerel Boyd, Karmali, Priya Prakash, Chivukula, Padmanabh, Kamrud, Kurt, Aliahmad, Parinaz, Wang, Nathaniel, Shresta, Sujan

“…Zika virus (ZIKV) is associated with congenital malformations in infants born to infected mothers, and with Guillain-Barré syndrome in infected adults…”
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