Minisatellite diversity supports a recent African origin for modern humans

Minisatellite diversity supports a recent African origin for modern humans

In a study of human diversity at a highly variable locus, we have mapped the internal structures of tandem-repetitive alleles from different populations at the minisatellite MS205 (D16S309). The results give an unusually detailed view of the different allelic structures represented on modern human c...

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Bibliographic Details
Published in:Nature genetics Vol. 13; no. 2; pp. 154 - 160
Main Authors: Armour, John A.L, Anttinen, Tiiu, May, Celia A, Vega, Emilce E, Sajantila, Antti, Kidd, Judith R, Kidd, Kenneth K, Bertranpetit, Jaume, Pääbo, Svante, Jeffreys, Alec J
Format: Journal Article
Language:English
Published: London Nature Publishing Group 01-06-1996
Subjects:
Africa
Alleles
Animals
Base Sequence
Biological and medical sciences
Biological Evolution
Classical genetics, quantitative genetics, hybrids
DNA, Satellite - genetics
Europe
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genetic Variation
Genetics of eukaryotes. Biological and molecular evolution
Hominidae - genetics
Human
Humans
Models, Genetic
Molecular Sequence Data
Polymerase Chain Reaction - methods
Africa
Europe
Human
Origin
Divergence
Genetic variability
Genetic marker
Minisatellite DNA
Biological evolution
World population
Anthropology
Tandemly repeated sequence
Polymorphism
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Summary:In a study of human diversity at a highly variable locus, we have mapped the internal structures of tandem-repetitive alleles from different populations at the minisatellite MS205 (D16S309). The results give an unusually detailed view of the different allelic structures represented on modern human chromosomes, and of the ancestral relationships between them. There was a clear difference in allelic diversity between African and non-African populations. A restricted set of allele families was found in non-African populations, and formed a subset of the much greater diversity seen on African chromosomes. The data strongly support a recent African origin for modern human diversity at this locus.
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ISSN:1061-4036
1546-1718
DOI:10.1038/ng0696-154