Search Results - "Veesler, David"

A Common Evolutionary Origin for Tailed-Bacteriophage Functional Modules and Bacterial Machineries by VEESLER, David, CAMBILLAU, Christian

“…Article Usage Stats Services MMBR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein by Walls, Alexandra C., Park, Young-Jun, Tortorici, M. Alejandra, Wall, Abigail, McGuire, Andrew T., Veesler, David

“…The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths. Coronavirus spike (S) glycoproteins promote entry into cells and are the main…”
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Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation by McCallum, Matthew, Walls, Alexandra C., Bowen, John E., Corti, Davide, Veesler, David

“…SARS-CoV-2 is the causative agent of the COVID-19 pandemic, with 10 million infections and more than 500,000 fatalities by June 2020. To initiate infection,…”
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Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion by Walls, Alexandra C., Tortorici, M. Alejandra, Snijder, Joost, Xiong, Xiaoli, Bosch, Berend-Jan, Rey, Felix A., Veesler, David

“…The tremendous pandemic potential of coronaviruses was demonstrated twice in the past few decades by two global outbreaks of deadly pneumonia. The coronavirus…”
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Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement by McCallum, Matthew, Czudnochowski, Nadine, Rosen, Laura E, Zepeda, Samantha K, Bowen, John E, Walls, Alexandra C, Hauser, Kevin, Joshi, Anshu, Stewart, Cameron, Dillen, Josh R, Powell, Abigail E, Croll, Tristan I, Nix, Jay, Virgin, Herbert W, Corti, Davide, Snell, Gyorgy, Veesler, David

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern evades antibody-mediated immunity that comes from vaccination or…”
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De novo design of picomolar SARS-CoV-2 miniprotein inhibitors by Cao, Longxing, Goreshnik, Inna, Coventry, Brian, Case, James Brett, Miller, Lauren, Kozodoy, Lisa, Chen, Rita E, Carter, Lauren, Walls, Alexandra C, Park, Young-Jun, Strauch, Eva-Maria, Stewart, Lance, Diamond, Michael S, Veesler, David, Baker, David

“…Targeting the interaction between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and the human angiotensin-converting enzyme 2…”
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Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding by Starr, Tyler N., Greaney, Allison J., Hilton, Sarah K., Ellis, Daniel, Crawford, Katharine H.D., Dingens, Adam S., Navarro, Mary Jane, Bowen, John E., Tortorici, M. Alejandra, Walls, Alexandra C., King, Neil P., Veesler, David, Bloom, Jesse D.

“…The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor and is a major determinant of host range and…”
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Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody by Pinto, Dora, Park, Young-Jun, Beltramello, Martina, Walls, Alexandra C., Tortorici, M. Alejandra, Bianchi, Siro, Jaconi, Stefano, Culap, Katja, Zatta, Fabrizia, De Marco, Anna, Peter, Alessia, Guarino, Barbara, Spreafico, Roberto, Cameroni, Elisabetta, Case, James Brett, Chen, Rita E., Havenar-Daughton, Colin, Snell, Gyorgy, Telenti, Amalio, Virgin, Herbert W., Lanzavecchia, Antonio, Diamond, Michael S., Fink, Katja, Veesler, David, Corti, Davide

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged coronavirus that is responsible for the current pandemic of coronavirus disease…”
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N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 by McCallum, Matthew, De Marco, Anna, Lempp, Florian A., Tortorici, M. Alejandra, Pinto, Dora, Walls, Alexandra C., Beltramello, Martina, Chen, Alex, Liu, Zhuoming, Zatta, Fabrizia, Zepeda, Samantha, di Iulio, Julia, Bowen, John E., Montiel-Ruiz, Martin, Zhou, Jiayi, Rosen, Laura E., Bianchi, Siro, Guarino, Barbara, Fregni, Chiara Silacci, Abdelnabi, Rana, Foo, Shi-Yan Caroline, Rothlauf, Paul W., Bloyet, Louis-Marie, Benigni, Fabio, Cameroni, Elisabetta, Neyts, Johan, Riva, Agostino, Snell, Gyorgy, Telenti, Amalio, Whelan, Sean P.J., Virgin, Herbert W., Corti, Davide, Pizzuto, Matteo Samuele, Veesler, David

“…The SARS-CoV-2 spike (S) glycoprotein contains an immunodominant receptor-binding domain (RBD) targeted by most neutralizing antibodies (Abs) in COVID-19…”
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Structural basis for human coronavirus attachment to sialic acid receptors by Tortorici, M. Alejandra, Walls, Alexandra C., Lang, Yifei, Wang, Chunyan, Li, Zeshi, Koerhuis, Danielle, Boons, Geert-Jan, Bosch, Berend-Jan, Rey, Félix A., de Groot, Raoul J., Veesler, David

“…Coronaviruses cause respiratory tract infections in humans and outbreaks of deadly pneumonia worldwide. Infections are initiated by the transmembrane spike (S)…”
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Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion by Walls, Alexandra C., Xiong, Xiaoli, Park, Young-Jun, Tortorici, M. Alejandra, Snijder, Joost, Quispe, Joel, Cameroni, Elisabetta, Gopal, Robin, Dai, Mian, Lanzavecchia, Antonio, Zambon, Maria, Rey, Félix A., Corti, Davide, Veesler, David

“…Recent outbreaks of severe acute respiratory syndrome and Middle East respiratory syndrome, along with the threat of a future coronavirus-mediated pandemic,…”
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Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy by Walls, Alexandra C, Tortorici, M Alejandra, Frenz, Brandon, Snijder, Joost, Li, Wentao, Rey, Félix A, DiMaio, Frank, Bosch, Berend-Jan, Veesler, David

“…Cryo-EM and mass spectrometry analyses of the spike glycoprotein trimer from coronavirus HcoV-NL63 reveal an extensive glycan shield that covers the protein…”
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SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern by McCallum, Matthew, Bassi, Jessica, De Marco, Anna, Chen, Alex, Walls, Alexandra C, Di Iulio, Julia, Tortorici, M Alejandra, Navarro, Mary-Jane, Silacci-Fregni, Chiara, Saliba, Christian, Sprouse, Kaitlin R, Agostini, Maria, Pinto, Dora, Culap, Katja, Bianchi, Siro, Jaconi, Stefano, Cameroni, Elisabetta, Bowen, John E, Tilles, Sasha W, Pizzuto, Matteo Samuele, Guastalla, Sonja Bernasconi, Bona, Giovanni, Pellanda, Alessandra Franzetti, Garzoni, Christian, Van Voorhis, Wesley C, Rosen, Laura E, Snell, Gyorgy, Telenti, Amalio, Virgin, Herbert W, Piccoli, Luca, Corti, Davide, Veesler, David

“…A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally detected in California, carries spike glycoprotein mutations S13I in the…”
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SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses by Walls, Alexandra C., Sprouse, Kaitlin R., Bowen, John E., Joshi, Anshu, Franko, Nicholas, Navarro, Mary Jane, Stewart, Cameron, Cameroni, Elisabetta, McCallum, Matthew, Goecker, Erin A., Degli-Angeli, Emily J., Logue, Jenni, Greninger, Alex, Corti, Davide, Chu, Helen Y., Veesler, David

“…Although infections among vaccinated individuals lead to milder COVID-19 symptoms relative to those in unvaccinated subjects, the specificity and durability of…”
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Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains by Starr, Tyler N, Greaney, Allison J, Stewart, Cameron M, Walls, Alexandra C, Hannon, William W, Veesler, David, Bloom, Jesse D

“…SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD) that impact ACE2 receptor binding, folding stability, and antibody…”
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Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies by Lempp, Florian A., Soriaga, Leah B., Montiel-Ruiz, Martin, Benigni, Fabio, Noack, Julia, Park, Young-Jun, Bianchi, Siro, Walls, Alexandra C., Bowen, John E., Zhou, Jiayi, Kaiser, Hannah, Joshi, Anshu, Agostini, Maria, Meury, Marcel, Dellota, Exequiel, Jaconi, Stefano, Cameroni, Elisabetta, Martinez-Picado, Javier, Vergara-Alert, Júlia, Izquierdo-Useros, Nuria, Virgin, Herbert W., Lanzavecchia, Antonio, Veesler, David, Purcell, Lisa A., Telenti, Amalio, Corti, Davide

“…SARS-CoV-2 infection—which involves both cell attachment and membrane fusion—relies on the angiotensin-converting enzyme 2 (ACE2) receptor, which is…”
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Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants by McCallum, Matthew, Walls, Alexandra C, Sprouse, Kaitlin R, Bowen, John E, Rosen, Laura E, Dang, Ha V, De Marco, Anna, Franko, Nicholas, Tilles, Sasha W, Logue, Jennifer, Miranda, Marcos C, Ahlrichs, Margaret, Carter, Lauren, Snell, Gyorgy, Pizzuto, Matteo Samuele, Chu, Helen Y, Van Voorhis, Wesley C, Corti, Davide, Veesler, David

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission leads to the emergence of variants, including the B.1.617.2 (Delta) variant of…”
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Automatic and accurate ligand structure determination guided by cryo-electron microscopy maps by Muenks, Andrew, Zepeda, Samantha, Zhou, Guangfeng, Veesler, David, DiMaio, Frank

“…Advances in cryo-electron microscopy (cryoEM) and deep-learning guided protein structure prediction have expedited structural studies of protein complexes…”
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Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays by Crawford, Katharine H D, Eguia, Rachel, Dingens, Adam S, Loes, Andrea N, Malone, Keara D, Wolf, Caitlin R, Chu, Helen Y, Tortorici, M Alejandra, Veesler, David, Murphy, Michael, Pettie, Deleah, King, Neil P, Balazs, Alejandro B, Bloom, Jesse D

“…SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera…”
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Structural basis for broad coronavirus neutralization by Sauer, Maximilian M., Tortorici, M. Alejandra, Park, Young-Jun, Walls, Alexandra C., Homad, Leah, Acton, Oliver J., Bowen, John E., Wang, Chunyan, Xiong, Xiaoli, de van der Schueren, Willem, Quispe, Joel, Hoffstrom, Benjamin G., Bosch, Berend-Jan, McGuire, Andrew T., Veesler, David

“…Three highly pathogenic β-coronaviruses have crossed the animal-to-human species barrier in the past two decades: SARS-CoV, MERS-CoV and SARS-CoV-2. To…”
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