Search Results - "Veeravalli, Krishna Kumar"

Mesenchymal Stem Cell Treatment Prevents Post-Stroke Dysregulation of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases by Chelluboina, Bharath, Nalamolu, Koteswara Rao, Mendez, Gustavo G., Klopfenstein, Jeffrey D., Pinson, David M, Wang, David Z, Veeravalli, Krishna Kumar

“…Background/Aims: Stem cell treatment is one of the potential treatment options for ischemic stroke. We recently demonstrated a protective effect of human…”
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Implications of MMP-12 in the pathophysiology of ischaemic stroke by Veeravalli, Krishna Kumar

“…This article focuses on the emerging role of matrix metalloproteinase-12 (MMP-12) in ischaemic stroke (IS). MMP-12 expression in the brain increases…”
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Matrix Metalloproteinase-12 Induces Blood–Brain Barrier Damage After Focal Cerebral Ischemia by Chelluboina, Bharath, Klopfenstein, Jeffrey D, Pinson, David M, Wang, David Z, Vemuganti, Raghu, Veeravalli, Krishna Kumar

“…BACKGROUND AND PURPOSE—Matrix metalloproteinases (MMPs) have a central role in compromising the integrity of the blood–brain barrier (BBB). The role of MMP-12…”
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Cardioprotective Activity of Alcoholic Extract of Tinospora cordifolia in Ischemia-Reperfusion Induced Myocardial Infarction in Rats by Rao, Pragada Rajeswara, Kumar, Veeravalli Krishna, Viswanath, Routhu Kasi, Subbaraju, Gottumukkala Venkata

“…It has been suggested that the beneficial effects of reperfusing the myocardium might be in part reversed by the occurrence of reperfusion injury. Oxidative…”
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Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1 by Nersesyan, Yelena, Demirkhanyan, Lusine, Cabezas-Bratesco, Deny, Oakes, Victoria, Kusuda, Ricardo, Dawson, Tyler, Sun, Xiaohui, Cao, Chike, Cohen, Alejandro Martin, Chelluboina, Bharath, Veeravalli, Krishna Kumar, Zimmermann, Katharina, Domene, Carmen, Brauchi, Sebastian, Zakharian, Eleonora

“…Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons project to the brainstem and spinal cord. Oxytocin release from these…”
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Editorial: Reviews in: stroke by Sehm, Bernhard, Barlinn, Kristian, Candelario-Jalil, Eduardo, Veeravalli, Krishna Kumar, Ni, Chunping, Yao, Jun

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Exosomes Treatment Mitigates Ischemic Brain Damage but Does Not Improve Post-Stroke Neurological Outcome by Nalamolu, Koteswara Rao, Venkatesh, Ishwarya, Mohandass, Adithya, Klopfenstein, Jeffrey D, Pinson, David M, Wang, David Z, Veeravalli, Krishna Kumar

“…Recent studies demonstrated that the treatment with mesenchymal stem cells (MSCs) obtained from the human umbilical cord blood improved survival, reduced brain…”
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Exosomes Secreted by the Cocultures of Normal and Oxygen–Glucose-Deprived Stem Cells Improve Post-stroke Outcome by Nalamolu, Koteswara Rao, Venkatesh, Ishwarya, Mohandass, Adithya, Klopfenstein, Jeffrey D., Pinson, David M., Wang, David Z., Kunamneni, Adinarayana, Veeravalli, Krishna Kumar

“…Emerging stroke literature suggests that treatment of experimentally induced stroke with stem cells offered post-stroke neuroprotection via exosomes produced…”
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MMP-12, a Promising Therapeutic Target for Neurological Diseases by Chelluboina, Bharath, Nalamolu, Koteswara Rao, Klopfenstein, Jeffrey D., Pinson, David M., Wang, David Z., Vemuganti, Raghu, Veeravalli, Krishna Kumar

“…The role of matrix metalloproteinase-12 (MMP-12) in the pathogenesis of several inflammatory diseases such as chronic obstructive pulmonary disease, emphysema,…”
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Temporal Regulation of Apoptotic and Anti-apoptotic Molecules After Middle Cerebral Artery Occlusion Followed by Reperfusion by Chelluboina, Bharath, Klopfenstein, Jeffrey D., Gujrati, Meena, Rao, Jasti S., Veeravalli, Krishna Kumar

“…A tremendous effort has been expended to elucidate the role of apoptotic molecules in ischemia. However, many agents that target apoptosis, despite their…”
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Therapeutic efficacy of matrix metalloproteinase-12 suppression on neurological recovery after ischemic stroke: Optimal treatment timing and duration by Challa, Siva Reddy, Nalamolu, Koteswara Rao, Fornal, Casimir A, Wang, Billy C, Martin, Ryan C, Olson, Elsa A, Ujjainwala, Ammar L, Pinson, David M, Klopfenstein, Jeffrey D, Veeravalli, Krishna Kumar

“…We recently showed that the post-ischemic induction of matrix metalloproteinase-12 (MMP-12) in the brain degrades tight junction proteins, increases MMP-9 and…”
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p53- and Bax-Mediated Apoptosis in Injured Rat Spinal Cord by Kotipatruni, Ramaprasada Rao, Dasari, Venkata Ramesh, Veeravalli, Krishna Kumar, Dinh, Dzung H., Fassett, Daniel, Rao, Jasti S.

“…Spinal cord injury (SCI) induces a series of endogenous biochemical changes that lead to secondary degeneration, including apoptosis. p53-mediated…”
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Glioma stem cell invasion through regulation of the interconnected ERK, integrin α6 and N-cadherin signaling pathway by Velpula, Kiran Kumar, Rehman, Azeem A., Chelluboina, Bharath, Dasari, Venkata Ramesh, Gondi, Christopher S., Rao, Jasti S., Veeravalli, Krishna Kumar

“…The recent characterization of glioma stem cells (GSCs) prompts a necessary examination of the signaling pathways that facilitate invasiveness. Molecular…”
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Stem cell treatment improves post stroke neurological outcomes: a comparative study in male and female rats by Nalamolu, Koteswara Rao, Chelluboina, Bharath, Fornal, Casimir A, Challa, Siva Reddy, Pinson, David M, Wang, David Z, Klopfenstein, Jeffrey D, Veeravalli, Krishna Kumar

“…Background and purposeThe therapeutic potential of different stem cells for ischaemic stroke treatment is intriguing and somewhat controversial. Recent results…”
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Human umbilical cord blood stem cells upregulate matrix metalloproteinase-2 in rats after spinal cord injury by Veeravalli, Krishna Kumar, Dasari, Venkata Ramesh, Tsung, Andrew J, Dinh, Dzung H, Gujrati, Meena, Fassett, Dan, Rao, Jasti S

“…Abstract Matrix metalloproteinases (MMPs) are a large family of proteolytic enzymes involved in inflammation, wound healing and other pathological processes…”
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The Impact of Social Isolation and Environmental Deprivation on Blood Pressure and Depression-Like Behavior in Young Male and Female Mice by Challa, Siva Reddy, Fornal, Casimir A., Wang, Billy C., Boyineni, Jerusha, DeVera, Roberto E., Unnam, Pavani, Song, Yajing, Soares, Marcelo Bento, Malchenko, Sergey, Gyarmati, Peter, Veeravalli, Krishna Kumar

“…Background: Social isolation (SI) and loneliness are major adult and adolescent health concerns, particularly in the coronavirus disease 2019 (COVID-19) era…”
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MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice by Veeravalli, Krishna Kumar, Chetty, Chandramu, Ponnala, Shivani, Gondi, Christopher S, Lakka, Sajani S, Fassett, Daniel, Klopfenstein, Jeffrey D, Dinh, Dzung H, Gujrati, Meena, Rao, Jasti S

“…Involvement of MMP-9, uPAR and cathepsin B in adhesion, migration, invasion, proliferation, metastasis and tumor growth has been well established. In the…”
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Regulation of DNA repair mechanism in human glioma xenograft cells both in vitro and in vivo in nude mice by Ponnala, Shivani, Veeravalli, Krishna Kumar, Chetty, Chandramu, Dinh, Dzung H, Rao, Jasti S

“…Glioblastoma Multiforme (GBM) is the most lethal form of brain tumor. Efficient DNA repair and anti-apoptotic mechanisms are making glioma treatment difficult…”
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Neuroprotection by cord blood stem cells against glutamate-induced apoptosis is mediated by Akt pathway by Dasari, Venkata Ramesh, Veeravalli, Krishna Kumar, Saving, Kay L, Gujrati, Meena, Fassett, Dan, Klopfenstein, Jeffrey D, Dinh, Dzung H, Rao, Jasti S

“…Abstract The neurotransmitter glutamate mediates excitatory synaptic transmission in the brain and spinal cord. In pathological conditions massive glutamate…”
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Urokinase plasminogen activator receptor and/or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells by Chetty, Chandramu, Lakka, Sajani S, Bhoopathi, Praveen, Gondi, Christopher S, Veeravalli, Krishna Kumar, Fassett, Daniel, Klopfenstein, Jeffrey D, Dinh, Dzung H, Gujrati, Meena, Rao, Jasti S

“…Small interfering RNA (siRNA)-mediated transcriptional knockdown of urokinase plasminogen activator receptor (uPAR) and matrix metalloproteinase-9 (MMP-9),…”
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