Search Results - "Veelen, Peter A."

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport by Jongsma, Marlieke L.M., Berlin, Ilana, Wijdeven, Ruud H.M., Janssen, Lennert, Janssen, George M.C., Garstka, Malgorzata A., Janssen, Hans, Mensink, Mark, van Veelen, Peter A., Spaapen, Robbert M., Neefjes, Jacques

“…Through a network of progressively maturing vesicles, the endosomal system connects the cell’s interior with extracellular space. Intriguingly, this network…”
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Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T‐cell activation by Rosalia, Rodney A., Quakkelaar, Esther D., Redeker, Anke, Khan, Selina, Camps, Marcel, Drijfhout, Jan W., Silva, Ana Luisa, Jiskoot, Wim, Hall, Thorbald, Veelen, Peter A., Janssen, George, Franken, Kees, Cruz, Luis J., Tromp, Angelino, Oostendorp, Jaap, Burg, Sjoerd H., Ossendorp, Ferry, Melief, Cornelis J. M.

“…The efficiency of antigen (Ag) processing by dendritic cells (DCs) is vital for the strength of the ensuing T‐cell responses. Previously, we and others have…”
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Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses by Lehmann, Kathleen C, Gulyaeva, Anastasia, Zevenhoven-Dobbe, Jessika C, Janssen, George M C, Ruben, Mark, Overkleeft, Hermen S, van Veelen, Peter A, Samborskiy, Dmitry V, Kravchenko, Alexander A, Leontovich, Andrey M, Sidorov, Igor A, Snijder, Eric J, Posthuma, Clara C, Gorbalenya, Alexander E

“…RNA viruses encode an RNA-dependent RNA polymerase (RdRp) that catalyzes the synthesis of their RNA(s). In the case of positive-stranded RNA viruses belonging…”
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ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab by Duarte, Henrique O., Rodrigues, Joana G., Gomes, Catarina, Hensbergen, Paul J., Ederveen, Agnes L. Hipgrave, de Ru, Arnoud H., Mereiter, Stefan, Polónia, António, Fernandes, Elisabete, Ferreira, José A., van Veelen, Peter A., Santos, Lúcio L., Wuhrer, Manfred, Gomes, Joana, Reis, Celso A.

“…The clinical performance of the therapeutic monoclonal antibody trastuzumab in the treatment of ErbB2-positive unresectable gastric cancer (GC) is severely…”
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Non‐prime‐ and prime‐side profiling of Pro‐Pro endopeptidase specificity using synthetic combinatorial peptide libraries and mass spectrometry by Claushuis, Bart, Cordfunke, Robert A., Ru, Arnoud H., Angeren, Jordy, Baumann, Ulrich, Veelen, Peter A., Wuhrer, Manfred, Corver, Jeroen, Drijfhout, Jan W., Hensbergen, Paul J.

“…A group of bacterial proteases, the Pro‐Pro endopeptidases (PPEPs), possess the unique ability to hydrolyze proline‐proline bonds in proteins. Since a…”
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The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling by Treffers, Emmely E, Tas, Ali, Scholte, Florine E M, de Ru, Arnoud H, Snijder, Eric J, van Veelen, Peter A, van Hemert, Martijn J

“…Chikungunya virus (CHIKV) is a reemerging alphavirus. Since 2005, it has infected millions of people during outbreaks in Africa, Asia, and South/Central…”
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Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes by Kracht, Maria J L, van Lummel, Menno, Nikolic, Tatjana, Joosten, Antoinette M, Laban, Sandra, van der Slik, Arno R, van Veelen, Peter A, Carlotti, Françoise, de Koning, Eelco J P, Hoeben, Rob C, Zaldumbide, Arnaud, Roep, Bart O

“…Use of an alternative open reading frame, potentially as a result of cellular stress, drives production of an unconventional insulin epitope that is recognized…”
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A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells by Luimstra, Jolien J, Garstka, Malgorzata A, Roex, Marthe C J, Redeker, Anke, Janssen, George M C, van Veelen, Peter A, Arens, Ramon, Falkenburg, J H Frederik, Neefjes, Jacques, Ovaa, Huib

“…Adaptive immunity is initiated by T cell recognition of specific antigens presented by major histocompatibility complexes (MHCs). MHC multimer technology has…”
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Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia by van der Lee, Dyantha I, Reijmers, Rogier M, Honders, Maria W, Hagedoorn, Renate S, de Jong, Rob Cm, Kester, Michel Gd, van der Steen, Dirk M, de Ru, Arnoud H, Kweekel, Christiaan, Bijen, Helena M, Jedema, Inge, Veelken, Hendrik, van Veelen, Peter A, Heemskerk, Mirjam Hm, Falkenburg, J H Frederik, Griffioen, Marieke

“…The most frequent subtype of acute myeloid leukemia (AML) is defined by mutations in the nucleophosmin 1 (NPM1) gene. Mutated NPM1 (ΔNPM1) is an attractive…”
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Efficient −2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein by Fang, Ying, Treffers, Emmely E, Li, Yanhua, Tas, Ali, Sun, Zhi, van der Meer, Yvonne, de Ru, Arnoud H, van Veelen, Peter A, Atkins, John F, Snijder, Eric J, Firth, Andrew E

“…Programmed −1 ribosomal frameshifting (−1 PRF) is a gene-expression mechanism used to express many viral and some cellular genes. In contrast, efficient…”
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T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes by Ali, Muhammad, Giannakopoulou, Eirini, Li, Yingqian, Lehander, Madeleine, Virding Culleton, Stina, Yang, Weiwen, Knetter, Cathrine, Odabasi, Mete Can, Bollineni, Ravi Chand, Yang, Xinbo, Foldvari, Zsofia, Böschen, Maxi-Lu, Taraldsrud, Eli, Strønen, Erlend, Toebes, Mireille, Hillen, Amy, Mazzi, Stefania, de Ru, Arnoud H., Janssen, George M. C., Kolstad, Arne, Tjønnfjord, Geir Erland, Lie, Benedicte A., Griffioen, Marieke, Lehmann, Sören, Osnes, Liv Toril, Buechner, Jochen, Garcia, K. Christopher, Schumacher, Ton N., van Veelen, Peter A., Leisegang, Matthias, Jacobsen, Sten Eirik W., Woll, Petter, Olweus, Johanna

“…Unlike chimeric antigen receptors, T-cell receptors (TCRs) can recognize intracellular targets presented on human leukocyte antigen (HLA) molecules. Here we…”
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Posttranslational modification of HLA-DQ binding islet autoantigens in type 1 diabetes by van Lummel, Menno, Duinkerken, Gaby, van Veelen, Peter A, de Ru, Arnoud, Cordfunke, Robert, Zaldumbide, Arnaud, Gomez-Touriño, Iria, Arif, Sefina, Peakman, Mark, Drijfhout, Jan W, Roep, Bart O

“…Posttranslational modification (PTM) of islet autoantigens can cause lack of central tolerance in type 1 diabetes (T1D). Tissue transglutaminase (tTG),…”
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The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis by Stavast, Christiaan J., van Zuijen, Iris, Karkoulia, Elena, Özçelik, Arman, van Hoven-Beijen, Antoinette, Leon, Leticia G., Voerman, Jane S. A., Janssen, George M. C., van Veelen, Peter A., Burocziova, Monika, Brouwer, Rutger W. W., van IJcken, Wilfred F. J., Maas, Alex, Bindels, Eric M., van der Velden, Vincent H. J., Schliehe, Christopher, Katsikis, Peter D., Alberich-Jorda, Meritxell, Erkeland, Stefan J.

“…MIR139 is a tumor suppressor and is commonly silenced in acute myeloid leukemia (AML). However, the tumor-suppressing activities of miR-139 and molecular…”
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PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin by Waard, Antonius A., Verkerk, Tamara, Jongsma, Marlieke L. M., Hoefakker, Kelly, Sethumadhavan, Sunesh, Gerke, Carolin, Bliss, Sophie, Kong, Xiangrui, Janssen, George M. C., Ru, Arnoud H., Claas, Frans H. J., Mulder, Arend, Tampé, Robert, Veelen, Peter A., Halenius, Anne, Spaapen, Robbert M.

“…A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for…”
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Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis by Rombouts, Yoann, Willemze, Annemiek, van Beers, Joyce J B C, Shi, Jing, Kerkman, Priscilla F, van Toorn, Linda, Janssen, George M C, Zaldumbide, Arnaud, Hoeben, Rob C, Pruijn, Ger J M, Deelder, André M, Wolbink, Gertjan, Rispens, Theo, van Veelen, Peter A, Huizinga, Tom W J, Wuhrer, Manfred, Trouw, Leendert A, Scherer, Hans U, Toes, René E M

“…To understand the molecular features distinguishing anti-citrullinated protein antibodies (ACPA) from 'conventional' antibodies in rheumatoid arthritis (RA)…”
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The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K by Mons, Elma, Jansen, Ineke D. C, Loboda, Jure, van Doodewaerd, Bjorn R, Hermans, Jill, Verdoes, Martijn, van Boeckel, Constant A. A, van Veelen, Peter A, Turk, Boris, Turk, Dusan, Ovaa, Huib

“…Irreversible covalent inhibitors can have a beneficial pharmacokinetic/pharmacodynamics profile but are still often avoided due to the risk of indiscriminate…”
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Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies by Kollenstart, Leonie, van der Horst, Sophie C., Vreeken, Kees, Janssen, George M. C., Martino, Fabrizio, Vlaming, Hanneke, van Veelen, Peter A., van Leeuwen, Fred, van Attikum, Haico

“…The collection of known posttranslational modifications (PTMs) has expanded rapidly with the identification of various non-acetyl histone lysine acylations,…”
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Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains by Abendstein, Leoni, Dijkstra, Douwe J., Tjokrodirijo, Rayman T. N., van Veelen, Peter A., Trouw, Leendert A., Hensbergen, Paul J., Sharp, Thomas H.

“…IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and enhanced effector functions, including highly efficient pathogen…”
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Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage by Shi, Jing, Knevel, Rachel, Suwannalai, Parawee, van der Linden, Michael P, Janssen, George M. C, van Veelen, Peter A, Levarht, Nivine E. W, van der Helm-van Mil, Annette H. M, Cerami, Anthony, Huizinga, Tom W. J, Toes, Rene E. M, Trouw, Leendert A

“…Autoimmune responses against posttranslationally modified antigens are a hallmark of several autoimmune diseases. For example, antibodies against citrullinated…”
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Minimal Information About an Immuno‐Peptidomics Experiment (MIAIPE) by Lill, Jennie R., Veelen, Peter A., Tenzer, Stefan, Admon, Arie, Caron, Etienne, Elias, Joshua E., Heck, Albert J.R., Marcilla, Miguel, Marino, Fabio, Müller, Markus, Peters, Bjoern, Purcell, Anthony, Sette, Alessandro, Sturm, Theo, Ternette, Nicola, Vizcaíno, Juan Antonio, Bassani‐Sternberg, Michal

“…Minimal information about an immuno‐peptidomics experiment (MIAIPE) is an initiative of the members of the Human Immuno‐Peptidome Project (HIPP), an…”
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