Search Results - "Vedin, Lise‐Lotte"

Soat2 ties cholesterol metabolism to β‐oxidation and glucose tolerance in male mice by Pramfalk, Camilla, Ahmed, Osman, Pedrelli, Matteo, Minniti, Mirko E., Luquet, Serge, Denis, Raphaël GP, Olin, Maria, Härdfeldt, Jennifer, Vedin, Lise‐Lotte, Steffensen, Knut R, Rydén, Mikael, Hodson, Leanne, Eriksson, Mats, Parini, Paolo

“…Background Sterol O‐acyltransferase 2 (Soat2) encodes acyl‐coenzyme A:cholesterol acyltransferase 2 (ACAT2), which synthesizes cholesteryl esters in…”
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Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα by Liang, Ning, Damdimopoulos, Anastasius, Goñi, Saioa, Huang, Zhiqiang, Vedin, Lise-Lotte, Jakobsson, Tomas, Giudici, Marco, Ahmed, Osman, Pedrelli, Matteo, Barilla, Serena, Alzaid, Fawaz, Mendoza, Arturo, Schröder, Tarja, Kuiper, Raoul, Parini, Paolo, Hollenberg, Anthony, Lefebvre, Philippe, Francque, Sven, Van Gaal, Luc, Staels, Bart, Venteclef, Nicolas, Treuter, Eckardt, Fan, Rongrong

“…Obesity triggers the development of non-alcoholic fatty liver disease (NAFLD), which involves alterations of regulatory transcription networks and epigenomes…”
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The oxysterol receptor LXR inhibits proliferation of human breast cancer cells by Vedin, Lise-Lotte, Lewandowski, Sebastian A., Parini, Paolo, Gustafsson, Jan-Åke, Steffensen, Knut R.

“…The oxysterol receptors [liver X receptors (LXRα and LXRβ)] regulate cholesterol and lipid biosynthesis and several studies link dysregulation of these…”
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Insights From Liver‐Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR‐Agonist Pharmacodynamics in Humans by Minniti, Mirko E., Pedrelli, Matteo, Vedin, Lise‐Lotte, Delbès, Anne‐Sophie, Denis, Raphaël G.P., Öörni, Katariina, Sala, Claudia, Pirazzini, Chiara, Thiagarajan, Divya, Nurmi, Harri J., Grompe, Markus, Mills, Kevin, Garagnani, Paolo, Ellis, Ewa C.S., Strom, Stephen C., Luquet, Serge H., Wilson, Elizabeth M., Bial, John, Steffensen, Knut R., Parini, Paolo

“…Background and Aims Genetically modified mice have been used extensively to study human disease. However, the data gained are not always translatable to humans…”
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The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis by Ferguson, Daniel, Zhang, Jun, Davis, Matthew A., Helsley, Robert N., Vedin, Lise-Lotte, Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Allende, Daniela S., Parini, Paolo, Brown, J.Mark

“…Hepatitis C virus (HCV) is an enveloped RNA virus responsible for 170 million cases of viral hepatitis worldwide. Over 50% of chronically infected HCV patients…”
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Liver X receptors induce antiproliferative effects in basal-like breast cancer by Haugen, Mads Haugland, von der Lippe Gythfeldt, Hedda, Egeland, Eivind Valen, Svartdal Normann, Lisa, Pandya, Abhilash D, Vedin, Lise-Lotte, Juell, Siri, Tenstad, Ellen, Øy, Geir Frode, Kristian, Alexandr, Marangoni, Elisabetta, Sørlie, Therese, Steffensen, Knut, Maelandsmo, Gunhild Mari, Engebraaten, Olav

“…Liver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose and fatty acid metabolism. The…”
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The oxysterol receptors lxrα and lxrβ suppress proliferation in the colon by Vedin, Lise-Lotte, Gustafsson, Jan-Åke, Steffensen, Knut R.

“…The oxysterol receptors LXRα and LXRβ are members of the nuclear receptor family and established transcriptional regulators of lipid metabolism with additional…”
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Liver × receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism by Nguyen-Vu, Trang, Vedin, Lise-Lotte, Liu, Ka, Jonsson, Philip, Lin, Jean Z, Candelaria, Nicholes R, Candelaria, Lindsay P, Addanki, Sridevi, Williams, Cecilia, Gustafsson, Jan-Åke, Steffensen, Knut R, Lin, Chin-Yo

“…Liver × receptors (LXRs) are members of the nuclear receptor family of ligand-dependent transcription factors and have established functions as regulators of…”
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Knockdown of SF-1 and RNF31 affects components of steroidogenesis, TGFβ, and Wnt/β-catenin signaling in adrenocortical carcinoma cells by Ehrlund, Anna, Jonsson, Philip, Vedin, Lise-Lotte, Williams, Cecilia, Gustafsson, Jan-Åke, Treuter, Eckardt

“…The orphan nuclear receptor Steroidogenic Factor-1 (SF-1, NR5A1) is a critical regulator of development and homeostasis of the adrenal cortex and gonads. We…”
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Potential Role of Thyroid Receptor β Agonists in the Treatment of Hyperlipidemia by Jakobsson, Tomas, Vedin, Lise-Lotte, Parini, Paolo

“…Thyroid hormones have important effects on cellular development, growth, and metabolism and are necessary for the healthy function of almost all tissues…”
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Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice by Han, Song‐iee, Komatsu, Yoko, Murayama, Akiko, Steffensen, Knut R., Nakagawa, Yoshimi, Nakajima, Yuka, Suzuki, Michiko, Oie, Shohei, Parini, Paolo, Vedin, Lise‐Lotte, Kishimoto, Hiroyuki, Shimano, Hitoshi, Gustafsson, Jan‐Åke, Yanagisawa, Junn

“…Liver X receptor (LXR) activation stimulates triglyceride (TG) accumulation in the liver. Several lines of evidence indicate that estradiol‐17β (E2) reduces TG…”
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The emerging roles of liver X receptors and their ligands in cancer by Lin, Chin-Yo, Vedin, Lise-Lotte, Steffensen, Knut R

“…Liver X receptors (LXRs) are nuclear receptors with well-known functions in cholesterol transport, fatty acid and glucose metabolism, and modulation of immune…”
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Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells by Candelaria, Nicholes R, Addanki, Sridevi, Zheng, Jine, Nguyen-Vu, Trang, Karaboga, Husna, Dey, Prasenjit, Gabbi, Chiara, Vedin, Lise-Lotte, Liu, Ka, Wu, Wanfu, Jonsson, Philip K, Lin, Jean Z, Su, Fei, Bollu, Lakshmi Reddy, Hodges, Sally E, McElhany, Amy L, Issazadeh, Mehdi A, Fisher, William E, Ittmann, Michael M, Steffensen, Knut R, Gustafsson, Jan-Åke, Lin, Chin-Yo

“…Pancreatic ductal adenocarcinoma (PDAC) is difficult to detect early and is often resistant to standard chemotherapeutic options, contributing to extremely…”
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Liver-humanized mice exhibit lipoprotein-specific phenotypes when grafted with human hepatocytes from different donors by Minniti, Mirko E., Vedin, Lise -Lotte, Wilson, Elizabeth M., Steffensen, Knut R., Parini, Paolo

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Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior by Delbès, Anne-Sophie, Quiñones, Mar, Gobet, Cédric, Castel, Julien, Denis, Raphaël G P, Berthelet, Jérémy, Weger, Benjamin D, Challet, Etienne, Charpagne, Aline, Metairon, Sylviane, Piccand, Julie, Kraus, Marine, Rohde, Bettina H, Bial, John, Wilson, Elizabeth M, Vedin, Lise-Lotte, Minniti, Mirko E, Pedrelli, Matteo, Parini, Paolo, Gachon, Frédéric, Luquet, Serge

“…The synchronization of circadian clock depends on a central pacemaker located in the suprachiasmatic nuclei. However, the potential feedback of peripheral…”
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Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice by Han, SI, Komatsu, Y, Murayama, A, Steffensen, KR, Nakagawa, Y, Nakajima, Y, Suzuki, M, Oie, S, Parini, P, Vedin, LL, Kishimoto, H, Shimano, H, Gustafsson, JA, Yanagisawa, J

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Liver X receptors induce antiproliferative effects in basal-like breast cancer by Haugen, Mads, von der Lippe Gythfeldt, Hedda, Egeland, Eivind Valen, Svartdal Normann, Lisa, Pandya, Abhilash D, Vedin, Lise-Lotte, Juell, Siri, Tenstad, Ellen, Øy, Geir Frode, Kristian, Alexandr, Marangoni, Elisabetta, Sørlie, Therese, Steffensen, Knut Rune, Mælandsmo, Gunhild Mari, Engebråten, Olav

“…Liver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose and fatty acid metabolism. The…”
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Liver x receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism by Nguyen-Vu, Trang, Vedin, Lise-Lotte, Liu, Ka, Jonsson, Philip, Lin, Jean Z, Candelaria, Nicholes R, Candelaria, Lindsay P, Addanki, Sridevi, Williams, Cecilia, Gustafsson, Jan-Ãke, Steffensen, Knut R, Lin, Chin-Yo

“…Introduction Liver x receptors (LXRs) are members of the nuclear receptor family of ligand-dependent transcription factors and have established functions as…”
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The oxysterol receptors lxr[alpha] and lxr[beta] suppress proliferation in the colon by Vedin, Lise-Lotte, Gustafsson, Jan-Åke, Steffensen, Knut R

“…The oxysterol receptors LXR[alpha] and LXR[beta] are members of the nuclear receptor family and established transcriptional regulators of lipid metabolism with…”
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Knockdown of SF-1 and RNF31 Affects Components of Steroidogenesis, TGF[beta], and Wnt/[beta]-catenin Signaling in Adrenocortical Carcinoma Cells by Ehrlund, Anna, Jonsson, Philip, Vedin, Lise-Lotte, Williams, Cecilia, Gustafsson, Jan-Åke, Treuter, Eckardt

“…The orphan nuclear receptor Steroidogenic Factor-1 (SF-1, NR5A1) is a critical regulator of development and homeostasis of the adrenal cortex and gonads. We…”
Get full text