New cyclic diarylheptanoids from the false heartwood of Betula pubescens Ehrh

New cyclic diarylheptanoids from the false heartwood of Betula pubescens Ehrh

Two undescribed (1-2) and five known cyclic diarylheptanoids (3-7) were isolated from the false heartwood of white birch (Betula pubescens Ehrh.). All structures were elucidated through extensive 1D and 2D NMR experiments and HR-ESI-MS data, along with comparison of their spectroscopic data with tho...

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Bibliographic Details
Published in:Natural product research Vol. 36; no. 21; pp. 5499 - 5507
Main Authors: Ponkratova, Anastasiia O., Vedernikov, Dmitry N., Whaley, Andrei K., Kuncova, Maria N., Smirnov, Sergey N., Serebryakov, Evgeny B., Spiridonova, Daria V., Luzhanin, Vladimir G.
Format: Journal Article
Language:English
Published: England Taylor & Francis 01-11-2022
Taylor & Francis Ltd
Subjects:
Antifungal activity
Antiinfectives and antibacterials
Antimicrobial activity
Betula pubescens
diarylheptanoids
E coli
Fungicides
Klebsiella
NMR
Nuclear magnetic resonance
secondary metabolites
white birch
diarylheptanoids
secondary metabolites
white birch
Betula pubescens
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Summary:Two undescribed (1-2) and five known cyclic diarylheptanoids (3-7) were isolated from the false heartwood of white birch (Betula pubescens Ehrh.). All structures were elucidated through extensive 1D and 2D NMR experiments and HR-ESI-MS data, along with comparison of their spectroscopic data with those reported in the literature. The two new cyclic diarylheptanoids are betuladiol (1) and betulondiol (2). Extracts from false heartwood were evaluated for their antimicrobial activity against Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Staphylococcus aureus and Cutibacterium acnes together with their antifungal activity against Candida albicans and Candida glabrata.
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.2017930