Search Results - "Vedanayagam, Jeffrey"

Regulatory logic of endogenous RNAi in silencing de novo genomic conflicts by Vedanayagam, Jeffrey, Lin, Ching-Jung, Papareddy, Ranjith, Nodine, Michael, Flynt, Alex S, Wen, Jiayu, Lai, Eric C

“…Although the biological utilities of endogenous RNAi (endo-RNAi) have been largely elusive, recent studies reveal its critical role in the non-model fruitfly…”
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Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis by Vedanayagam, Jeffrey, Chatila, Walid K., Aksoy, Bülent Arman, Majumdar, Sonali, Skanderup, Anders Jacobsen, Demir, Emek, Schultz, Nikolaus, Sander, Chris, Lai, Eric C.

“…Somatic mutations in the RNase IIIb domain of DICER1 arise in cancer and disrupt the cleavage of 5' pre-miRNA arms. Here, we characterize an unstudied,…”
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The hpRNA/RNAi Pathway Is Essential to Resolve Intragenomic Conflict in the Drosophila Male Germline by Lin, Ching-Jung, Hu, Fuqu, Dubruille, Raphaelle, Vedanayagam, Jeffrey, Wen, Jiayu, Smibert, Peter, Loppin, Benjamin, Lai, Eric C.

“…Intragenomic conflicts are fueled by rapidly evolving selfish genetic elements, which induce selective pressures to innovate opposing repressive mechanisms…”
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Gene flow mediates the role of sex chromosome meiotic drive during complex speciation by Meiklejohn, Colin D, Landeen, Emily L, Gordon, Kathleen E, Rzatkiewicz, Thomas, Kingan, Sarah B, Geneva, Anthony J, Vedanayagam, Jeffrey P, Muirhead, Christina A, Garrigan, Daniel, Stern, David L, Presgraves, Daven C

“…During speciation, sex chromosomes often accumulate interspecific genetic incompatibilities faster than the rest of the genome. The drive theory posits that…”
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Rapid evolutionary dynamics of an expanding family of meiotic drive factors and their hpRNA suppressors by Vedanayagam, Jeffrey, Lin, Ching-Jung, Lai, Eric C.

“…Meiotic drivers are a class of selfish genetic elements whose existence is frequently hidden due to concomitant suppressor systems. Accordingly, we know little…”
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New genes often acquire male-specific functions but rarely become essential in Drosophila by Kondo, Shu, Vedanayagam, Jeffrey, Mohammed, Jaaved, Eizadshenass, Sogol, Kan, Lijuan, Pang, Nan, Aradhya, Rajaguru, Siepel, Adam, Steinhauer, Josefa, Lai, Eric C

“…Relatively little is known about the in vivo functions of newly emerging genes, especially in metazoans. Although prior RNAi studies reported prevalent…”
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Rapid evolutionary diversification of the flamenco locus across simulans clade Drosophila species by Signor, Sarah, Vedanayagam, Jeffrey, Kim, Bernard Y, Wierzbicki, Filip, Kofler, Robert, Lai, Eric C

“…Suppression of transposable elements (TEs) is paramount to maintain genomic integrity and organismal fitness. In D. melanogaster, the flamenco locus is a…”
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Essential and recurrent roles for hairpin RNAs in silencing de novo sex chromosome conflict in Drosophila simulans by Vedanayagam, Jeffrey, Herbette, Marion, Mudgett, Holly, Lin, Ching-Jung, Lai, Chun-Ming, McDonough-Goldstein, Caitlin, Dorus, Stephen, Loppin, Benjamin, Meiklejohn, Colin, Dubruille, Raphaëlle, Lai, Eric C

“…Meiotic drive loci distort the normally equal segregation of alleles, which benefits their own transmission even in the face of severe fitness costs to their…”
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The effects of natural selection across molecular pathways in Drosophila melanogaster by Vedanayagam, Jeffrey P, Garrigan, Daniel

“…Whole-genome RNA interference post-transcriptional silencing (RNAi) is a widely used method for studying the phenotypic effects of knocking down individual…”
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Genome diversity and divergence in Drosophila mauritiana: multiple signatures of faster X evolution by Garrigan, Daniel, Kingan, Sarah B, Geneva, Anthony J, Vedanayagam, Jeffrey P, Presgraves, Daven C

“…Drosophila mauritiana is an Indian Ocean island endemic species that diverged from its two sister species, Drosophila simulans and Drosophila sechellia,…”
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The m6A pathway facilitates sex determination in Drosophila by Kan, Lijuan, Grozhik, Anya V., Vedanayagam, Jeffrey, Patil, Deepak P., Pang, Nan, Lim, Kok-Seong, Huang, Yi-Chun, Joseph, Brian, Lin, Ching-Jung, Despic, Vladimir, Guo, Jian, Yan, Dong, Kondo, Shu, Deng, Wu-Min, Dedon, Peter C., Jaffrey, Samie R., Lai, Eric C.

“…The conserved modification N 6 -methyladenosine (m 6 A) modulates mRNA processing and activity. Here, we establish the Drosophila system to study the m 6 A…”
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Genome Diversity and Divergence in Drosophila mauritiana: Multiple Signatures of Faster X Evolution by Garrigan, Daniel, Kingan, Sarah B, Geneva, Anthony J, Vedanayagam, Jeffrey P, Presgraves, Daven C

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The m 6 A pathway facilitates sex determination in Drosophila by Kan, Lijuan, Grozhik, Anya V, Vedanayagam, Jeffrey, Patil, Deepak P, Pang, Nan, Lim, Kok-Seong, Huang, Yi-Chun, Joseph, Brian, Lin, Ching-Jung, Despic, Vladimir, Guo, Jian, Yan, Dong, Kondo, Shu, Deng, Wu-Min, Dedon, Peter C, Jaffrey, Samie R, Lai, Eric C

“…The conserved modification N -methyladenosine (m A) modulates mRNA processing and activity. Here, we establish the Drosophila system to study the m A pathway…”
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Evolution of genome structure in the Drosophila simulans species complex by Chakraborty, Mahul, Chang, Ching-Ho, Khost, Danielle E, Vedanayagam, Jeffrey, Adrion, Jeffrey R, Liao, Yi, Montooth, Kristi L, Meiklejohn, Colin D, Larracuente, Amanda M, Emerson, J J

“…The rapid evolution of repetitive DNA sequences, including satellite DNA, tandem duplications, and transposable elements, underlies phenotypic evolution and…”
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Regulated dicing of pre-mir-144 via reshaping of its terminal loop by Shang, Renfu, Kretov, Dmitry A, Adamson, Scott I, Treiber, Thomas, Treiber, Nora, Vedanayagam, Jeffrey, Chuang, Jeffrey H, Meister, Gunter, Cifuentes, Daniel, Lai, Eric C

“…Although the route to generate microRNAs (miRNAs) is often depicted as a linear series of sequential and constitutive cleavages, we now appreciate multiple…”
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Evolutionary Genomics of piRNA Mediated Transposon Silencing in Drosophila by Vedanayagam, Jeffrey P

“…Transposable elements (TEs) are abundant throughout the genomes of most living organisms. A recently identified piwi-interacting RNA (piRNA) pathway has been…”
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Selective enrichment of human DNA from non-human DNAs for DNA typing of decomposed skeletal remains by Nandineni, Madhusudan R., Vedanayagam, Jeffrey P.

“…The degraded or decomposed body remains pose serious challenges for successful short tandem repeat (STR)-based DNA typing for human identification because of…”
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