Search Results - "Vecsler, Manuela"

An artificial intelligence algorithm for prostate cancer diagnosis in whole slide images of core needle biopsies: a blinded clinical validation and deployment study by Pantanowitz, Liron, Quiroga-Garza, Gabriela M, Bien, Lilach, Heled, Ronen, Laifenfeld, Daphna, Linhart, Chaim, Sandbank, Judith, Albrecht Shach, Anat, Shalev, Varda, Vecsler, Manuela, Michelow, Pamela, Hazelhurst, Scott, Dhir, Rajiv

“…There is high demand to develop computer-assisted diagnostic tools to evaluate prostate core needle biopsies (CNBs), but little clinical validation and a lack…”
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Using standard optical flow cytometry for synchronizing proliferating cells in the G1 phase by Vecsler, Manuela, Lazar, Itay, Tzur, Amit

“…Cell cycle research greatly relies on synchronization of proliferating cells. However, effective synchronization of mammalian cells is commonly achieved by…”
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Validation and real-world clinical application of an artificial intelligence algorithm for breast cancer detection in biopsies by Sandbank, Judith, Bataillon, Guillaume, Nudelman, Alona, Krasnitsky, Ira, Mikulinsky, Rachel, Bien, Lilach, Thibault, Lucie, Albrecht Shach, Anat, Sebag, Geraldine, Clark, Douglas P., Laifenfeld, Daphna, Schnitt, Stuart J., Linhart, Chaim, Vecsler, Manuela, Vincent-Salomon, Anne

“…Breast cancer is the most common malignant disease worldwide, with over 2.26 million new cases in 2020. Its diagnosis is determined by a histological review of…”
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A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance by Loebstein, Ronen, Dvoskin, Ilana, Halkin, Hillel, Vecsler, Manuela, Lubetsky, Aharon, Rechavi, Gideon, Amariglio, Ninette, Cohen, Yoram, Ken-Dror, Gie, Almog, Shlomo, Gak, Eva

“…CYP2C9 and VKORC1 genetic variants are associated with low and intermediate warfarin dose requirements, but markers of high doses are less well characterized…”
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Unbiased transcriptome signature of in vivo cell proliferation reveals pro- and antiproliferative gene networks by Cohen, Meital, Vecsler, Manuela, Liberzon, Arthur, Noach, Meirav, Zlotorynski, Eitan, Tzur, Amit

“…Different types of mature B-cell lymphocytes are overall highly similar. Nevertheless, some B cells proliferate intensively, while others rarely do. Here, we…”
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Ex vivo treatment with a novel synthetic aminoglycoside NB54 in primary fibroblasts from Rett syndrome patients suppresses MECP2 nonsense mutations by Vecsler, Manuela, Ben Zeev, Bruria, Nudelman, Igor, Anikster, Yair, Simon, Amos J, Amariglio, Ninette, Rechavi, Gideon, Baasov, Timor, Gak, Eva

“…Nonsense mutations in the X-linked methyl CpG-binding protein 2 (MECP2) comprise a significant proportion of causative MECP2 mutations in Rett syndrome (RTT)…”
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Gas2l3, a novel constriction site-associated protein whose regulation is mediated by the APC/C Cdh1 complex by Pe'er, Tal, Lahmi, Roxane, Sharaby, Yaara, Chorni, Evelin, Noach, Meirav, Vecsler, Manuela, Zlotorynski, Eitan, Steen, Hanno, Steen, Judith A, Tzur, Amit

“…Growth arrest-specific 2-like protein 3 (Gas2l3) was recently identified as an Actin/Tubulin cross-linker protein that regulates cytokinesis. Using cell-free…”
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MeCP2 deficiency down-regulates specific nuclear proteins that could be partially recovered by valproic acid in vitro by Vecsler, Manuela, Simon, Amos J., Amariglio, Ninette, Rechavi, Gideon, Gak, Eva

“…MeCP2, the major causative factor of Rett syndrome and related phenotypes including autism, is a two-face nuclear modulator acting via transcriptional and…”
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The interface of nanoparticles with proliferating mammalian cells by Panet, Einat, Mashriki, Tal, Lahmi, Roxane, Jacob, Abraham, Ozer, Efrat, Vecsler, Manuela, Lazar, Itay, Tzur, Amit

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Abstract PD11-04: A multi-feature AI-based solution for cancer diagnosis in breast biopsies: A prospective blinded multi-site clinical study by Vincent-Salomon, Anne, Bataillon, Guillaume, Nudelman, Alona, Sandbank, Judith, Shach, Anat Albrecht, Thibault, Lucie, Bien, Lilach, Mikulinsky, Rachel, Krasnitsky, Ira, Heled, Ronen, Linhart, Chaim, Vecsler, Manuela, Laifenfeld, Daphna

“…Objective This study aimed to clinically validate the performance of a multi-feature AI-based solution on detection of invasive versus in situ carcinomas and…”
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Validation of prostate and breast cancer detection artificial intelligence algorithms for accurate histopathological diagnosis and grading: a retrospective study with a Japanese cohort by Lami, Kris, Yoon, Han-Seung, Parwani, Anil V., Pham, Hoa Hoang Ngoc, Tachibana, Yuri, Linhart, Chaim, Grinwald, Maya, Vecsler, Manuela, Fukuoka, Junya

“…Prostate and breast cancer incidence rates have been on the rise in Japan, emphasising the need for precise histopathological diagnosis to determine patient…”
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Epilepsy in Rett syndrome—The experience of a National Rett Center by Nissenkorn, Andreea, Gak, Eva, Vecsler, Manuela, Reznik, Haia, Menascu, Shay, Ben Zeev, Bruria

“…Summary Purpose:  Rett syndrome (RTT), an X‐linked, dominant neurodevelopmental disorder caused by mutations in the methyl‐CpG‐binding protein 2 (MECP2) gene,…”
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Combined genetic profiles of components and regulators of the vitamin K-dependent gamma-carboxylation system affect individual sensitivity to warfarin by Vecsler, Manuela, Loebstein, Ronen, Almog, Shlomo, Kurnik, Daniel, Goldman, Boleslav, Halkin, Hillel, Gak, Eva

“…We examined the influence of combined genotypes on interindividual variability in warfarin dose-response. In 100 anticoagulated patients we quantified the…”
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Fully Automated Artificial Intelligence Solution for Human Epidermal Growth Factor Receptor 2 Immunohistochemistry Scoring in Breast Cancer: A Multireader Study by Krishnamurthy, Savitri, Schnitt, Stuart J, Vincent-Salomon, Anne, Canas-Marques, Rita, Colon, Eugenia, Kantekure, Kanchan, Maklakovski, Marina, Finck, Wilfrid, Thomassin, Jeanne, Globerson, Yuval, Bien, Lilach, Mallel, Giuseppe, Grinwald, Maya, Linhart, Chaim, Sandbank, Judith, Vecsler, Manuela

“…The proven efficacy of human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate therapy for treating HER2-low breast cancers necessitates more…”
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Abstract P6-04-07: Primary Diagnosis of Breast Biopsies supported by AI versus Microscope: Multi-Site Clinical Reader Study by Salomon, Anne, Nudelman, Alona, Cyrta, Joanna, Maklakovski, Marina, Shach, Anat Albrecht, Sebag, Geraldine, Mallel, Giuseppe, Krasnitsky, Ira, Feinberg, Tali, Vecsler, Manuela, Sandbank, Judith

“…Objective This study aimed to clinically validate the use of an AI-based solution by pathologists for the primary diagnosis of breast core needle biopsies as…”
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MeCP2 deficiency downregulates specific nuclear proteins that could be partially recovered by valproic acid in vitro by Vecsler, Manuela, Simon, Amos J, Amariglio, Ninette, Rechavi, Gideon, Gak, Eva

“…MeCP2, the major causative factor of Rett syndrome and related phenotypes including autism, is a two-face nuclear modulator acting via transcriptional and…”
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Using Standard Optical Flow Cytometry for Synchronizing Proliferating Cells in the G1 Phase: e83935 by Vecsler, Manuela, Lazar, Itay, Tzur, Amit

“…Cell cycle research greatly relies on synchronization of proliferating cells. However, effective synchronization of mammalian cells is commonly achieved by…”
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Gas2l3, a Novel Constriction Site-Associated Protein Whose Regulation Is Mediated by the APC/CCdh1 Complex by Pe’er, Tal, Lahmi, Roxane, Sharaby, Yaara, Chorni, Evelin, Noach, Meirav, Vecsler, Manuela, Zlotorynski, Eitan, Steen, Hanno, Steen, Judith A., Tzur, Amit

“…Growth arrest-specific 2-like protein 3 (Gas2l3) was recently identified as an Actin/Tubulin cross-linker protein that regulates cytokinesis. Using cell-free…”
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Common Genetic Variants of Microsomal Epoxide Hydrolase Affect Warfarin Dose Requirements Beyond the Effect of Cytochrome P450 2C9 by Loebstein, Ronen, Vecsler, Manuela, Kurnik, Daniel, Austerweil, Naomi, Gak, Eva, Halkin, Hillel, Almog, Shlomo

“…Background Warfarin dose response is partially explained by the polymorphisms in the cytochrome P450 (CYP) 2C9 gene, affecting S‐warfarin clearance, as well as…”
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