Search Results - "Vecchio, Michele"

Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma: a randomised, double-blind, multicentre, phase 3 trial by Ascierto, Paolo A, Dr, Del Vecchio, Michele, MD, Robert, Caroline, Prof, Mackiewicz, Andrzej, Prof, Chiarion-Sileni, Vanna, MD, Arance, Ana, MD, Lebbé, Céleste, Prof, Bastholt, Lars, MD, Hamid, Omid, MD, Rutkowski, Piotr, Prof, McNeil, Catriona, MD, Garbe, Claus, Prof, Loquai, Carmen, MD, Dreno, Brigitte, Prof, Thomas, Luc, Prof, Grob, Jean-Jacques, Prof, Liszkay, Gabriella, Prof, Nyakas, Marta, MD, Gutzmer, Ralf, Prof, Pikiel, Joanna, MD, Grange, Florent, MD, Hoeller, Christoph, MD, Ferraresi, Virginia, MD, Smylie, Michael, MD, Schadendorf, Dirk, Prof, Mortier, Laurent, Prof, Svane, Inge Marie, MD, Hennicken, Delphine, MSc, Qureshi, Anila, MD, Maio, Michele, MD

“…Summary Background A phase 2 trial suggested increased overall survival and increased incidence of treatment-related grade 3–4 adverse events with ipilimumab…”
Get full text

Dabrafenib, trametinib and pembrolizumab or placebo in BRAF-mutant melanoma by Ascierto, Paolo Antonio, Ferrucci, Pier Francesco, Fisher, Rosalie, Del Vecchio, Michele, Atkinson, Victoria, Schmidt, Henrik, Schachter, Jacob, Queirolo, Paola, Long, Georgina V., Di Giacomo, Anna Maria, Svane, Inge Marie, Lotem, Michal, Bar-Sela, Gil, Couture, Felix, Mookerjee, Bijoyesh, Ghori, Razi, Ibrahim, Nageatte, Moreno, Blanca Homet, Ribas, Antoni

“…Blocking programmed death 1 (PD-1) may enhance the durability of anti-tumor responses that are induced by the combined inhibition of BRAF and MEK 1 . Here we…”
Get full text

Binimetinib versus dacarbazine in patients with advanced NRAS -mutant melanoma (NEMO): a multicentre, open-label, randomised, phase 3 trial by Dummer, Reinhard, Prof, Schadendorf, Dirk, Prof, Ascierto, Paolo A, MD, Arance, Ana, MD, Dutriaux, Caroline, MD, Di Giacomo, Anna Maria, MD, Rutkowski, Piotr, Prof, Del Vecchio, Michele, MD, Gutzmer, Ralf, Prof, Mandala, Mario, MD, Thomas, Luc, Prof, Demidov, Lev, Prof, Garbe, Claus, Prof, Hogg, David, MD, Liszkay, Gabriella, Prof, Queirolo, Paola, MD, Wasserman, Ernesto, MD, Ford, James, MS, Weill, Marine, MSc, Sirulnik, L Andres, MD, Jehl, Valentine, MSc, Bozón, Viviana, MD, Long, Georgina V, Prof, Flaherty, Keith, MD

“…Summary Background There are no established therapies specific for NRAS -mutant melanoma despite the emergence of immunotherapy. We aimed to assess the…”
Get full text

Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key by Castrogiovanni, Paola, Di Rosa, Michelino, Ravalli, Silvia, Castorina, Alessandro, Guglielmino, Claudia, Imbesi, Rosa, Vecchio, Michele, Drago, Filippo, Szychlinska, Marta Anna, Musumeci, Giuseppe

“…The purpose of this study was to investigate the influence of moderate physical activity (MPA) on the expression of osteoarthritis (OA)-related (IL-1β, IL-6,…”
Get full text

Speech rehabilitation in dysarthria after stroke: a systematic review of the studies by Chiaramonte, Rita, Pavone, Piero, Vecchio, Michele

“…Speech difficulties such as dysarthria or aphasia are frequently seen, in addition to motor impairments, in subjects after stroke. Literature searches with the…”
Get full text

An Integrated Pharmacophore/Docking/3D-QSAR Approach to Screening a Large Library of Products in Search of Future Botulinum Neurotoxin A Inhibitors by Gentile, Davide, Floresta, Giuseppe, Patamia, Vincenzo, Chiaramonte, Rita, Mauro, Giulia Letizia, Rescifina, Antonio, Vecchio, Michele

“…Botulinum toxins are neurotoxins produced by . This toxin can be lethal for humans as a cause of botulism; however, in small doses, the same toxin is used to…”
Get full text

T Lymphocytes Redirected against the Chondroitin Sulfate Proteoglycan-4 Control the Growth of Multiple Solid Tumors both In Vitro and In Vivo by GELDRES, Claudia, SAVOLDO, Barbara, DOTTI, Gianpietro, HOYOS, Valentina, CARUANA, Ignazio, MING ZHANG, YVON, Eric, DEL VECCHIO, Michele, CREIGHTON, Chad J, ITTMANN, Michael, FERRONE, Soldano

“…Because of its high expression on various types of tumors and its restricted distribution in normal tissues, chondroitin sulfate proteoglycan-4 (CSPG4)…”
Get full text

Haemophilic arthropathy: A narrative review on the use of intra‐articular drugs for arthritis by Buccheri, Enrico, Avola, Marianna, Vitale, Nicolò, Pavone, Piero, Vecchio, Michele

“…Introduction Intra‐articular injections of various drugs are commonly used in patients with degenerative osteoarthritis and also in haemophilic patients…”
Get full text

Do proprioceptive training strategies with dual-task exercises positively influence gait parameters in chronic stroke? A systematic review by Vecchio, Michele, Chiaramonte, Rita, De Sire, Alessandro, Buccheri, Enrico, Finocchiaro, Patrizia, Scaturro, Dalila, Letizia Mauro, Giulia, Cioni, Matteo

“…This study aims to assess the impact of proprioceptive training strategies with dual-task exercises on gait in people with chronic stroke. Systematic review…”
Get full text

The role of exercise on peripheral nerve regeneration: from animal model to clinical application by Maugeri, Grazia, D'Agata, Velia, Trovato, Bruno, Roggio, Federico, Castorina, Alessandro, Vecchio, Michele, Di Rosa, Michelino, Musumeci, Giuseppe

“…Peripheral nerve injury is a complex condition with a variety of signs and symptoms depending on the severity and nerves involved. Peripheral nerve damage may…”
Get full text

Immune-related adverse events correlate with improved survival in patients undergoing anti-PD1 immunotherapy for metastatic melanoma by Indini, Alice, Di Guardo, Lorenza, Cimminiello, Carolina, Prisciandaro, Michele, Randon, Giovanni, De Braud, Filippo, Del Vecchio, Michele

“…Background Therapeutic chances for metastatic melanoma have consistently changed over the last years with the advent of antibodies targeting the programmed…”
Get full text

Thermography and rasterstereography as a combined infrared method to assess the posture of healthy individuals by Roggio, Federico, Petrigna, Luca, Trovato, Bruno, Zanghì, Marta, Sortino, Martina, Vitale, Ermanno, Rapisarda, Lucia, Testa, Gianluca, Pavone, Vito, Pavone, Piero, Vecchio, Michele, Musumeci, Giuseppe

“…The demand for noninvasive methods to assess postural defections is increasing because back alterations are more common among the healthy population. We…”
Get full text

Efficacy and safety of ipilimumab in patients with advanced melanoma and brain metastases by Queirolo, Paola, Spagnolo, Francesco, Ascierto, Paolo Antonio, Simeone, Ester, Marchetti, Paolo, Scoppola, Alessandro, Del Vecchio, Michele, Di Guardo, Lorenza, Maio, Michele, Di Giacomo, Anna Maria, Antonuzzo, Andrea, Cognetti, Francesco, Ferraresi, Virginia, Ridolfi, Laura, Guidoboni, Massimo, Guida, Michele, Pigozzo, Jacopo, Chiarion Sileni, Vanna

“…Patients with melanoma brain metastases have a poor prognosis and historically have been excluded from clinical trials. The Expanded Access Program (EAP)…”
Get full text

Botulinum Toxin Dilution and Endplate Targeting in Spasticity: A Double-Blind Controlled Study by Gracies, Jean-Michel, MD, Lugassy, Mara, MD, Weisz, Donald J., PhD, Vecchio, Michele, MD, Flanagan, Steve, MD, Simpson, David M., MD

“…Abstract Gracies J-M, Lugassy M, Weisz DJ, Vecchio M, Flanagan S, Simpson DM. Botulinum toxin dilution and endplate targeting in spasticity: a double-blind…”
Get full text

The Pan-Immune-Inflammation Value in Patients with Metastatic Melanoma Receiving First-Line Therapy by Fucà, Giovanni, Beninato, Teresa, Bini, Marta, Mazzeo, Laura, Di Guardo, Lorenza, Cimminiello, Carolina, Randon, Giovanni, Apollonio, Giulia, Bisogno, Ilaria, Del Vecchio, Marta, Lauria Pantano, Claudia, Di Nicola, Massimo, de Braud, Filippo, Del Vecchio, Michele

“…Background Since a non-negligible fraction of patients with metastatic melanoma does not experience long-term disease control, even with immunotherapy and…”
Get full text

Rehabilitation approach in robot assisted total knee arthroplasty: an observational study by Scaturro, Dalila, Vitagliani, Fabio, Caracappa, Dario, Tomasello, Sofia, Chiaramonte, Rita, Vecchio, Michele, Camarda, Lawrence, Mauro, Giulia Letizia

“…The purpose of this study is to evaluate the impact of total knee arthroplasty (TKA) with the aid of Navio Robot, comparing it with standard prosthetic surgery…”
Get full text

Mitigating the Functional Deficit after Neurotoxic Motoneuronal Loss by an Inhibitor of Mitochondrial Fission by Ciuro, Maria, Sangiorgio, Maria, Cacciato, Valeria, Cantone, Giuliano, Fichera, Carlo, Salvatorelli, Lucia, Magro, Gaetano, Leanza, Giampiero, Vecchio, Michele, Valle, Maria Stella, Gulino, Rosario

“…Amyotrophic lateral sclerosis (ALS) is an extremely complex neurodegenerative disease involving different cell types, but motoneuronal loss represents its main…”
Get full text

Immunotherapy of Metastatic Melanoma Using Genetically Engineered GD2-Specific T cells by YVON, Eric, DEL VECCHIO, Michele, SAVOLDO, Barbara, HOYOS, Valentina, DUTOUR, Aurélie, ANICHINI, Andrea, DOTTI, Gianpietro, BRENNER, Malcolm K

“…Purpose: Genetic engineering of human T lymphocytes to express tumor-directed chimeric antigen receptors (CAR) can produce antitumor effector cells that bypass…”
Get full text

Adjuvant nivolumab versus ipilimumab in resected stage IIIB–C and stage IV melanoma (CheckMate 238): 4-year results from a multicentre, double-blind, randomised, controlled, phase 3 trial by Ascierto, Paolo A, Del Vecchio, Michele, Mandalá, Mario, Gogas, Helen, Arance, Ana M, Dalle, Stephane, Cowey, C Lance, Schenker, Michael, Grob, Jean-Jacques, Chiarion-Sileni, Vanna, Márquez-Rodas, Iván, Butler, Marcus O, Maio, Michele, Middleton, Mark R, de la Cruz-Merino, Luis, Arenberger, Petr, Atkinson, Victoria, Hill, Andrew, Fecher, Leslie A, Millward, Michael, Khushalani, Nikhil I, Queirolo, Paola, Lobo, Maurice, de Pril, Veerle, Loffredo, John, Larkin, James, Weber, Jeffrey

“…Previously, findings from CheckMate 238, a double-blind, phase 3 adjuvant trial in patients with resected stage IIIB–C or stage IV melanoma, showed significant…”
Get full text

Immune Suppression and Response to Ipilimumab: Assessing Risk-to-Benefit Ratio by Indini, Alice, Di Nicola, Massimo, Del Vecchio, Michele, De Braud, Filippo

Get full text