Pyrazolo[1,5-a]pyridines as p38 Kinase Inhibitors

A convergent synthesis of substituted pyrazolo[1,5-a]pyridines has been achieved either via a regioselective [3 + 2] cycloaddition of N-aminopyridines with alkynes or by thermal cyclization of disubstituted azirines. Subsequent palladium-catalyzed introduction of pyridines or de novo synthesis of py...

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Bibliographic Details
Published in:	Organic letters Vol. 7; no. 21; pp. 4753 - 4756
Main Authors:	Stevens, Kirk L, Jung, David K, Alberti, Michael J, Badiang, Jennifer G, Peckham, Gregory E, Veal, Jim M, Cheung, Mui, Harris, Philip A, Chamberlain, Stanley D, Peel, Michael R
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 13-10-2005
Subjects:	Crystallography, X-Ray Molecular Structure p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Pyrazoles - chemistry Pyrazoles - pharmacology Pyridines - chemistry Pyridines - pharmacology Structure-Activity Relationship
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Summary:	A convergent synthesis of substituted pyrazolo[1,5-a]pyridines has been achieved either via a regioselective [3 + 2] cycloaddition of N-aminopyridines with alkynes or by thermal cyclization of disubstituted azirines. Subsequent palladium-catalyzed introduction of pyridines or de novo synthesis of pyrimidines affords inhibitors of p38 kinase.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol0519745