The Effects of Resistance Exercise on the Cardiorespiratory Tissue of Rats with Parkinson's Disease

Parkinson's Disease (PD) affects the cardiorespiratory system, causing an increase in the left ventricular mass in the heart and respiratory muscle weakness in relation to healthy individuals. The objective of this study was to investigate the effects of progressive resistive physical exercise...

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Bibliographic Details
Published in:	International journal of environmental research and public health Vol. 20; no. 4; p. 2925
Main Authors:	Moreira, Graziele Mayra Santos, Damázio, Laila Cristina Moreira, Silva, Silvana Venâncio da, Silveira, Augusto Targino, Mesquita, Isabella Giordano, Silva, Luana Aparecida de Sousa, Pereira, Luan Alves, Costa, Ana Clara Silva, Santos, Ismael Augusto Lima, Campos, Maria Eduarda Paiva, Vaz, Luna Sara Campos, Cardoso, Zenaide Alves, Gomes, José Victor Ribeiro Silva, Júnior, Paulo Henrique Almeida Campos, Ide, Liliam Midori
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 08-02-2023 MDPI
Subjects:	Alcohol Animal tissues Animals Cardiac muscle Diaphragm Diaphragm (anatomy) Electrodes Exercise Heart Histomorphometry Hypertrophy Muscles Neurons Parkinson's disease Physical exercise Physical training Substantia nigra Surgery Ventricle Brazil exercise muscles Parkinson’s disease heart
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Summary:	Parkinson's Disease (PD) affects the cardiorespiratory system, causing an increase in the left ventricular mass in the heart and respiratory muscle weakness in relation to healthy individuals. The objective of this study was to investigate the effects of progressive resistive physical exercise on the vertical ladder on the histomorphometry of cardiac tissue and respiratory muscles in rats with PD. Seventy male Wistar rats, aged 40 days old, were divided into Parkinson's (PD) and Sham (SH) groups; they were also subdivided into groups that performed progressive resistive physical exercise on the vertical ladder Before Surgery (ExBS), After Surgery (ExAS), and Before and After Surgery (ExBAS). The physical training was carried out before and/or after PD induction. Exercise was performed five times a week for 25 min/day for four or eight weeks. PD induction was conducted via electrolytic stimulation of the of the animals' brains, adopting the following stereotaxic table coordinates: -4.9; lateral medium equal to 1.7, and dorsoventral equal to 8.1. For the morphometric analysis of the heart, the following variables were calculated: relative weight and diameter and thickness of the left ventricle. The diaphragm and the myocardial, intercostal, and abdominal muscles were stained with Hematoxylin and Eosin (HE). The histomorphometric analysis was performed using the ImageJ software to assess the cross-sectional area of muscles and the number of muscle fibers. Progressive resistance exercise promoted the hypertrophy of respiratory muscles and the left ventricle in animals with PD.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1660-4601 1661-7827 1660-4601
DOI:	10.3390/ijerph20042925