Search Results - "Vauterin, Stephan"

A reliable and reproducible ELISA method to measure ristocetin cofactor activity of von Willebrand factor by Vanhoorelbeke, K, Cauwenberghs, N, Vauterin, S, Schlammadinger, A, Mazurier, C, Deckmyn, H

“…The ristocetin induced binding of vWF to GPIb, which is routinely tested in a platelet agglutination assay, can be reproducibly studied in an ELISA where…”
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Antithrombotic Effect of Platelet Glycoprotein Ib–Blocking Monoclonal Antibody Fab Fragments in Nonhuman Primates by Cauwenberghs, Nancy, Meiring, Muriel, Vauterin, Stephan, van Wyk, Veronika, Lamprecht, Seb, Roodt, Jan P, Novák, Levente, Harsfalvi, Jolan, Deckmyn, Hans, Kotzé, Harry F

“…Platelet adhesion in arterial blood flow is mainly supported by the platelet receptor glycoprotein (GP) Ib, which interacts with von Willebrand factor (vWF)…”
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Paratope Determination of the Antithrombotic Antibody 82D6A3 Based on the Crystal Structure of Its Complex with the von Willebrand Factor A3-Domain by Staelens, Stephanie, Hadders, Michael A., Vauterin, Stephan, Platteau, Céline, De Maeyer, Marc, Vanhoorelbeke, Karen, Huizinga, Eric G., Deckmyn, Hans

“…The antithrombotic monoclonal antibody 82D6A3 is directed against amino acids Arg-963, Pro-981, Asp-1009, Arg-1016, Ser-1020, Met-1022, and His-1023 of the von…”
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Type 2B von Willebrand disease in seven individuals from three different families: phenotypic and genotypic characterization by Szántó, Tímea, Schlammadinger, Agota, Salles, Isabelle, Pareyn, Inge, Vauterin, Stephan, Hársfalvi, Jolán, Vanden Bulcke, Anne-Marie, Deckmyn, Hans, Vanhoorelbeke, Karen

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Fc-receptor dependent platelet aggregation induced by monoclonal antibodies against platelet glycoprotein Ib or von Willebrand factor by Cauwenberghs, N, Schlammadinger, A, Vauterin, S, Cooper, S, Descheemaeker, G, Tornai, I, Deckmyn, H

“…In this paper we describe two pathways leading to platelet activation by crosslinking glycoprotein (GP) Ibalpha to the platelet Fc-receptor (FcgammaRII). First…”
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Humanization by variable domain resurfacing and grafting on a human IgG4, using a new approach for determination of non-human like surface accessible framework residues based on homology modelling of variable domains by Staelens, Stephanie, Desmet, Johan, Ngo, Thu Hoa, Vauterin, Stephan, Pareyn, Inge, Barbeaux, Philippe, Van Rompaey, Isabel, Stassen, Jean-Marie, Deckmyn, Hans, Vanhoorelbeke, Karen

“…Many antithrombotic agents have only a small therapeutic window, frequently leading to bleeding problems. However, interfering with platelet adhesion through…”
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Von Willebrand Factor But Not α-Thrombin Binding to Platelet Glycoprotein Ibα Is Influenced by the HPA-2 Polymorphism by Ulrichts, Hans, Vanhoorelbeke, Karen, Cauwenberghs, Sandra, Vauterin, Stephan, Kroll, Hartmut, Santoso, Sentot, Deckmyn, Hans

“…OBJECTIVE—Glycoprotein (GP) Ibα is the functionally dominant subunit of the platelet GPIb-IX-V receptor complex. The N-terminal domain of the GPIbα chain…”
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Epitope mapping of inhibitory antibodies against platelet glycoprotein Ibα reveals interaction between the leucine-rich repeat N-terminal and C-terminal flanking domains of glycoprotein Ibα by Cauwenberghs, Nancy, Vanhoorelbeke, Karen, Vauterin, Stephan, Westra, Douwe F., Romo, Gabriel, Huizinga, Eric G., Lopez, José A., Berndt, Michael C., Harsfalvi, Jolàn, Deckmyn, Hans

“…The interaction of von Willebrand factor (vWF) with the platelet receptor glycoprotein Ibα (GPIbα) is important for platelet adhesion at high shear stress. Two…”
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The A/T1381 polymorphism in the A1-domain of von Willebrand factor influences the affinity of von Willebrand factor for platelet glycoprotein Ibalpha by Szántó, Tímea, Schlammadinger, Agota, Staelens, Stephanie, De Meyer, Simon F, Freson, Kathleen, Pareyn, Inge, Vauterin, Stephan, Hársfalvi, Jolán, Deckmyn, Hans, Vanhoorelbeke, Karen

“…Many polymorphisms in vonWillebrand factor (VWF) have been reported and their association with VWF plasma levels or cardiovascular diseases has been…”
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Newly Developed ADAMTS13 Antigen Assay Reveals Marked Ethnic Differences and Depletion in Acquired Thrombotic Thrombocytopenic Purpura by Feys, Hendrik B., Liu, Fang, Dong, Ningzheng, Pareyn, Inge, Vauterin, Stephan, Vandeputte, Nele, Ruan, Changgeng, Hans, Deckmyn, Karen, Vanhoorelbeke

“…ADAMTS13 is a metalloprotease that cleaves the A2-domain of von Willebrand factor, resulting in a normal processed protein. A defective or blocked enzyme…”
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Plasma glycocalicin as a source of GPIbalpha in the von Willebrand factor ristocetin cofactor ELISA by Vanhoorelbeke, Karen, Pareyn, Inge, Schlammadinger, Agota, Vauterin, Stephan, Hoylaerts, Marc F, Arnout, Jef, Deckmyn, Hans

“…We have previously demonstrated that the von Willebrand factor ristocetin cofactor activity (VWF:RCo), used in the diagnosis of vonWillebrand disease (VWD),…”
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How does agkicetin-C bind on platelet glycoprotein Ibα and achieve its platelet effects? by Xu, Gufeng, Ulrichts, Hans, Vauterin, Stephan, De Meyer, Simon F., Deckmyn, Hans, Teng, Maikun, Niu, Liwen

“…The platelet glycoprotein (GP) Ib-IX-V receptor complex has a central role in primary haemostasis and possesses binding sites for the plasmatic adhesive…”
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How does agkicetin-C bind on platelet glycoprotein Ibalpha and achieve its platelet effects? by Xu, Gufeng, Ulrichts, Hans, Vauterin, Stephan, De Meyer, Simon F, Deckmyn, Hans, Teng, Maikun, Niu, Liwen

“…The platelet glycoprotein (GP) Ib-IX-V receptor complex has a central role in primary haemostasis and possesses binding sites for the plasmatic adhesive…”
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Humanization by variable domain resurfacing and grafting on a human IgG sub(4), using a new approach for determination of non-human like surface accessible framework residues based on homology modelling of variable domains by Staelens, Stephanie, Desmet, Johan, Ngo, Thu Hoa, Vauterin, Stephan, Pareyn, Inge, Barbeaux, Philippe, Van Rompaey, Isabel, Stassen, Jean-Marie, Deckmyn, Hans, Vanhoorelbeke, Karen

“…Many antithrombotic agents have only a small therapeutic window, frequently leading to bleeding problems. However, interfering with platelet adhesion through…”
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How does agkicetin-C bind on platelet glycoprotein Iba and achieve its platelet effects? by GUFENG XU, ULRICHTS, Hans, VAUTERIN, Stephan, DE MEYER, Simon F, DECKMYN, Hans, MAIKUN TENG, LIWEN NIU

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Humanization by variable domain resurfacing and grafting on a human IgG 4, using a new approach for determination of non-human like surface accessible framework residues based on homology modelling of variable domains by Staelens, Stephanie, Desmet, Johan, Ngo, Thu Hoa, Vauterin, Stephan, Pareyn, Inge, Barbeaux, Philippe, Van Rompaey, Isabel, Stassen, Jean-Marie, Deckmyn, Hans, Vanhoorelbeke, Karen

“…Many antithrombotic agents have only a small therapeutic window, frequently leading to bleeding problems. However, interfering with platelet adhesion through…”
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A Reliable von Willebrand factor: ristocetin cofactor enzyme-linked immunosorbent assay to differentiate between type 1 and type 2 von Willebrand disease by Vanhoorelbeke, Karen, Cauwenberghs, Nancy, Vandecasteele, Griet, Vauterin, Stephan, Deckmyn, Hans

“…von Willebrand disease (vWD) is the most common hereditary bleeding disorder due to either a qualitative or a quantitative defect in von Willebrand factor…”
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Antithrombotic effect of platelet glycoprotein Ib-blocking monclonal antibody fab fragments in nonhuman primates by Cauwenberghs, Nancy, Meiring, Muriel, Vauterin, Stephan, Veronika van Wyk

“…Platelet adhesion in arterial blood flow is mainly supported by the platelet receptor glycoprotein (GP) Ib, which interacts with von Willebrand factor (vWF)…”
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von Willebrand factor but not alpha-thrombin binding to platelet glycoprotein Ibalpha is influenced by the HPA-2 polymorphism by Ulrichts, Hans, Vanhoorelbeke, Karen, Cauwenberghs, Sandra, Vauterin, Stephan, Kroll, Hartmut, Santoso, Sentot, Deckmyn, Hans

“…Glycoprotein (GP) Ibalpha is the functionally dominant subunit of the platelet GPIb-IX-V receptor complex. The N-terminal domain of the GPIbalpha chain…”
Get full text