Search Results - "Vaughn, Marcie"

Flavin-Containing Monooxygenase Activity in Hepatocytes and Microsomes: In Vitro Characterization and In Vivo Scaling of Benzydamine Clearance by FISHER, Michael B, YOON, Kwansik, VAUGHN, Marcie L, STRELEVITZ, Timothy J, FOTI, Robert S

“…Liver microsomes, and more recently cryopreserved hepatocytes, are commonly used in the in vitro characterization of the metabolism of new xenobiotics. The…”
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Synthesis and biological activity of piperazine-Based dual MMP-13 and TNF-α converting enzyme inhibitors by Letavic, Michael A., Barberia, John T., Carty, Thomas J., Hardink, Joel R., Liras, Jennifer, Lopresti-Morrow, Lori L., Mitchell, Peter G., Noe, Mark C., Reeves, Lisa M., Snow, Sheri L., Stam, Ethan J., Sweeney, Francis J., Vaughn, Marcie L., Yu, Chul H.

“…A series of novel MMP-13 and TNF-α converting enzyme inhibitors based on piperazine 2-hydroxamic acid scaffolds are described. The TACE, MMP-1 and MMP-13…”
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Potent, selective pyrimidinetrione-based inhibitors of MMP-13 by Reiter, Lawrence A., Freeman-Cook, Kevin D., Jones, Christopher S., Martinelli, Gary J., Antipas, Amy S., Berliner, Martin A., Datta, Kaushik, Downs, James T., Eskra, James D., Forman, Michael D., Greer, Elaine M., Guzman, Roberto, Hardink, Joel R., Janat, Fouad, Keene, Nandell F., Laird, Ellen R., Liras, Jennifer L., Lopresti-Morrow, Lori L., Mitchell, Peter G., Pandit, Jayvardhan, Robertson, Donald, Sperger, Diana, Vaughn-Bowser, Marcie L., Waller, Darra M., Yocum, Sue A.

“…Using SAR from two related series of pyrimidinetrione-based inhibitors, compounds with potent MMP-13 inhibition and >100-fold selectivity against other MMPs…”
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Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14 by Blagg, Julian A., Noe, Mark C., Wolf-Gouveia, Lilli A., Reiter, Lawrence A., Laird, Ellen R., Chang, Shang-Poa P., Danley, Dennis E., Downs, James T., Elliott, Nancy C., Eskra, James D., Griffiths, Richard J., Hardink, Joel R., Haugeto, Amber I., Jones, Christopher S., Liras, Jennifer L., Lopresti-Morrow, Lori L., Mitchell, Peter G., Pandit, Jayvardhan, Robinson, Ralph P., Subramanyam, Chakrapani, Vaughn-Bowser, Marcie L., Yocum, Sue A.

“…[Display omitted] Through the use of computational modeling, a series of pyrimidinetrione-based inhibitors of MMP-13 was designed based on a lead inhibitor…”
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Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13 by Freeman-Cook, Kevin D., Reiter, Lawrence A., Noe, Mark C., Antipas, Amy S., Danley, Dennis E., Datta, Kaushik, Downs, James T., Eisenbeis, Shane, Eskra, James D., Garmene, David J., Greer, Elaine M., Griffiths, Richard J., Guzman, Roberto, Hardink, Joel R., Janat, Fouad, Jones, Christopher S., Martinelli, Gary J., Mitchell, Peter G., Laird, Ellen R., Liras, Jennifer L., Lopresti-Morrow, Lori L., Pandit, Jayvardhan, Reilly, Usa D., Robertson, Donald, Vaughn-Bowser, Marcie L., Wolf-Gouviea, Lilli A., Yocum, Sue A.

“…The discovery of novel, selective spirocyclic inhibitors of MMP-13 is reported. Explorations in the pyrimidinetrione series of MMP-13 inhibitors led to the…”
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Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1 by Reiter, Lawrence A., Robinson, Ralph P., McClure, Kim F., Jones, Christopher S., Reese, Matthew R., Mitchell, Peter G., Otterness, Ivan G., Bliven, Marcia L., Liras, Jennifer, Cortina, Santo R., Donahue, Kathleen M., Eskra, James D., Griffiths, Richard J., Lame, Mary E., Lopez-Anaya, Arturo, Martinelli, Gary J., McGahee, Shunda M., Yocum, Sue A., Lopresti-Morrow, Lori L., Tobiassen, Lisa M., Vaughn-Bowser, Marcie L.

“…Graphic The SAR of a series of sterically hindered sulfonamide hydroxamic acids with relatively large P 1′ groups is described. The compounds typically spare…”
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Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13 by Noe, Mark C., Natarajan, Vijayalakshmi, Snow, Sheri L., Mitchell, Peter G., Lopresti-Morrow, Lori, Reeves, Lisa M., Yocum, Sue A., Carty, Thomas J., Barberia, John A., Sweeney, Francis J., Liras, Jennifer L., Vaughn, Marcie, Hardink, Joel R., Hawkins, Joel M., Tokar, Christopher

“…A series of pipecolic hydroxamate inhibitors of MMP-13 and aggrecanase was discovered based on screening known inhibitors of TNF-α converting enzyme (TACE)…”
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Discovery of 3-OH-3-methylpipecolic hydroxamates: Potent orally active inhibitors of aggrecanase and MMP-13 by Noe, Mark C., Natarajan, Vijayalakshmi, Snow, Sheri L., Wolf-Gouveia, Lilli A., Mitchell, Peter G., Lopresti-Morrow, Lori, Reeves, Lisa M., Yocum, Sue A., Otterness, Ivan, Bliven, Marcia A., Carty, Thomas J., Barberia, John T., Sweeney, Francis J., Liras, Jennifer L., Vaughn, Marcie

“…[Display omitted] A series of 3-hydroxy-3-methylpipecolic hydroxamate inhibitors of MMP-13 and aggrecanase was designed based on the observation of increased…”
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3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase by Noe, Mark C., Snow, Sheri L., Wolf-Gouveia, Lilli A., Mitchell, Peter G., Lopresti-Morrow, Lori, Reeves, Lisa M., Yocum, Sue A., Liras, Jennifer L., Vaughn, Marcie

“…N-Hydroxy-3-hydroxy-4-arylsulfonyltetrahydropyranyl-3-carboxamides were designed as novel inhibitors of MMP-13 and aggrecanase based on known endocyclic…”
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