Search Results - "Vaughan, Ted J"

A coarse-grained molecular dynamics investigation of the role of mineral arrangement on the mechanical properties of mineralized collagen fibrils by Tavakol, Mahdi, Vaughan, Ted J

“…Mineralized collagen fibrils (MCFs) comprise collagen molecules and hydroxyapatite (HAp) crystals and are considered universal building blocks of bone tissue,…”
Get full text

The Effect of Substrate Stiffness, Thickness, and Cross-Linking Density on Osteogenic Cell Behavior by Mullen, Conleth A., Vaughan, Ted J., Billiar, Kristen L., McNamara, Laoise M.

“…Osteogenic cells respond to mechanical changes in their environment by altering their spread area, morphology, and gene expression profile. In particular, the…”
Get full text

Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates by Haugh, Matthew G., Vaughan, Ted J., Madl, Christopher M., Raftery, Rosanne M., McNamara, Laoise M., O'Brien, Fergal J., Heilshorn, Sarah C.

“…Dimensionality can have a profound impact on stiffness-mediated differentiation of mesenchymal stem cells (MSCs). However, while we have begun to understand…”
Get full text

Fluid flow in the osteocyte mechanical environment: a fluid–structure interaction approach by Verbruggen, Stefaan W., Vaughan, Ted J., McNamara, Laoise M.

“…Osteocytes are believed to be the primary sensor of mechanical stimuli in bone, which orchestrate osteoblasts and osteoclasts to adapt bone structure and…”
Get full text

Mechanisms of osteocyte stimulation in osteoporosis by Verbruggen, Stefaan W., Vaughan, Ted J., McNamara, Laoise M.

“…Experimental studies have shown that primary osteoporosis caused by oestrogen-deficiency results in localised alterations in bone tissue properties and mineral…”
Get full text

Linking the effect of localised pitting corrosion with mechanical integrity of a rare earth magnesium alloy for implant use by van Gaalen, Kerstin, Quinn, Conall, Benn, Felix, McHugh, Peter E., Kopp, Alexander, Vaughan, Ted J.

“…This study presents a computational framework that investigates the effect of localised surface-based corrosion on the mechanical performance of a…”
Get full text

How to Validate in silico Deployment of Coronary Stents: Strategies and Limitations in the Choice of Comparator by Berti, Francesca, Antonini, Luca, Poletti, Gianluca, Fiuza, Constantino, Vaughan, Ted J, Migliavacca, Francesco, Petrini, Lorenza, Pennati, Giancarlo

“…This study aims at proposing and discussing useful indications to all those who need to validate a numerical model of coronary stent deployment. The proof of…”
Get full text

Automated ex-situ detection of pitting corrosion and its effect on the mechanical integrity of rare earth magnesium alloy - WE43 by van Gaalen, Kerstin, Gremse, Felix, Benn, Felix, McHugh, Peter E., Kopp, Alexander, Vaughan, Ted J.

“…This study develops a three-dimensional automated detection framework (PitScan) that systematically evaluates the severity and phenomenology of pitting…”
Get full text

High-Speed Cutting of Synthetic Trabecular Bone—A Combined Experimental–Computational Investigation by O’Neill, Macdarragh, Vaughan, Ted J.

“…Orthopaedic surgical cutting instruments are required to generate sufficient forces to penetrate bone tissue while minimising the risk of thermal and…”
Get full text

Predicting localised corrosion and mechanical performance of a PEO surface modified rare earth magnesium alloy for implant use through in-silico modelling by van Gaalen, Kerstin, Quinn, Conall, Weiler, Marek, Gremse, Felix, Benn, Felix, McHugh, Peter E., Vaughan, Ted J., Kopp, Alexander

“…In this study, the influence of a plasma electrolytic oxidation (PEO) surface treatment on a medical-grade WE43-based magnesium alloy is examined through an…”
Get full text

Design and Verification of a Novel Perfusion Bioreactor to Evaluate the Performance of a Self-Expanding Stent for Peripheral Artery Applications by Nandan, Swati, Schiavi-Tritz, Jessica, Hellmuth, Rudolf, Dunlop, Craig, Vaughan, Ted J., Dolan, Eimear B.

“…Endovascular stenting presents a promising approach to treat peripheral artery stenosis. However, a significant proportion of patients require secondary…”
Get full text

The effect of equiaxial stretching on the osteogenic differentiation and mechanical properties of human adipose stem cells by Virjula, Sanni, Zhao, Feihu, Leivo, Joni, Vanhatupa, Sari, Kreutzer, Joose, Vaughan, Ted J., Honkala, Anna-Maija, Viehrig, Marlitt, Mullen, Conleth A., Kallio, Pasi, McNamara, Laoise M., Miettinen, Susanna

“…Although mechanical cues are known to affect stem cell fate and mechanobiology, the significance of such stimuli on the osteogenic differentiation of human…”
Get full text

Hybrid Mineral/Organic Material Induces Bone Bridging and Bone Volume Augmentation in Rat Calvarial Critical Size Defects by Dubus, Marie, Scomazzon, Loïc, Ledouble, Charlotte, Braux, Julien, Beljebbar, Abdelilah, Van Gulick, Laurence, Baldit, Adrien, Gorin, Caroline, Alem, Halima, Bouland, Nicole, Britton, Marissa, Schiavi, Jessica, Vaughan, Ted J, Mauprivez, Cédric, Kerdjoudj, Halima

“…In craniofacial bone defects, the promotion of bone volume augmentation remains a challenge. Finding strategies for bone regeneration such as combining…”
Get full text

Energy dissipation of osteopontin at a HAp mineral interface: Implications for bone biomechanics by Tavakol, Mahdi, Vaughan, Ted J.

“…Osteopontin (OPN) is a one of the most abundant non-collagenous proteins in the bone's organic matrix. OPN is responsible for mediating bonding at mineral…”
Get full text

The structural role of osteocalcin in bone biomechanics and its alteration in Type-2 Diabetes by Tavakol, Mahdi, Vaughan, Ted J.

“…This study presents an investigation into the role of Osteocalcin (OC) on bone biomechanics, with the results demonstrating that the protein’s α-helix…”
Get full text

A Novel Dual Non-Invasive Ventilator Continuous Positive Airway Pressure Non-Aerosolization Circuit for Emergency Use in the COVID-19 Pandemic by Vaughan, Ted J., Kirrane, Frank, Moerman, Kevin M., Cahill, Tara, O’Regan, Anthony, O’Keeffe, Derek T.

“…The COVID-19 pandemic is a public health emergency of unprecedented scale. The surge in clinical cases of patients with severe respiratory illness has…”
Get full text

An investigation on the effects of in vitro induced advanced glycation end-products on cortical bone fracture mechanics at fall-related loading rates by Britton, Marissa, Parle, Eoin, Vaughan, Ted J.

“…It has been suggested that adverse changes in bone quality due to the accumulation of advanced glycation end-products (AGEs) may play a role in the increased…”
Get full text

Micromechanical modelling of transverse fracture behaviour of lamellar bone using a phase-field damage model: The role of non-collagenous proteins and mineralised collagen fibrils by Alijani, Hamid, Vaughan, Ted J.

“…At the tissue-scale and above, there are now well-established structure-property relationships that provide good approximations of the biomechanical…”
Get full text

Exploring the hierarchical structure of lamellar bone and its impact on fracture behaviour: A computational study using a phase field damage model by Alijani, Hamid, Vaughan, Ted J.

“…Bone is a naturally occurring composite material composed of a stiff mineral phase and a compliant organic matrix of collagen and non-collagenous proteins…”
Get full text

Bone Mineral Is More Heterogeneously Distributed in the Femoral Heads of Osteoporotic and Diabetic Patients: A Pilot Study by Parle, Eoin, Tio, Sherdya, Behre, Annie, Carey, John J, Murphy, Colin G, O'Brien, Timothy F, Curtin, William A, Kearns, Stephen R, McCabe, John P, Coleman, Cynthia M, Vaughan, Ted J, McNamara, Laoise M

“…ABSTRACT Osteoporosis is associated with systemic bone loss, leading to a significant deterioration of bone microarchitecture and an increased fracture risk…”
Get full text