Search Results - "Vaughan, Patricia S"
-
1
Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis
Published in The Journal of cell biology (01-12-2008)“…Cytoplasmic dynein functions at several sites during mitosis; however, the basis of targeting to each site remains unclear. Tandem mass spectrometry analysis…”
Get full text
Journal Article -
2
Dynactin Is Required for Bidirectional Organelle Transport
Published in The Journal of cell biology (03-02-2003)“…Kinesin II is a heterotrimeric plus end-directed microtubule motor responsible for the anterograde movement of organelles in various cell types. Despite…”
Get full text
Journal Article -
3
Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores
Published in Molecular biology of the cell (15-09-2011)“…Aurora B (AurB) is a mitotic kinase responsible for multiple aspects of mitotic progression, including assembly of the outer kinetochore. Cytoplasmic dynein is…”
Get full text
Journal Article -
4
StARD9 is a novel lysosomal kinesin required for membrane tubulation, cholesterol transport and Purkinje cell survival
Published in Journal of cell science (01-03-2023)“…The pathological accumulation of cholesterol is a signature feature of Niemann-Pick type C (NPC) disease, in which excessive lipid levels induce Purkinje cell…”
Get full text
Journal Article -
5
The Roadblock Light Chain Binds a Novel Region of the Cytoplasmic Dynein Intermediate Chain
Published in The Journal of biological chemistry (06-09-2002)“…Cytoplasmic dynein is the major minus-end directed microtubule-based motor in eukaryotic cells. It is composed of a number of different subunits including…”
Get full text
Journal Article -
6
Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2
Published in Nature (London) (28-09-1995)“…The human histone H4 gene FO108 is regulated during the cell cycle with a peak in transcription during early S phase. The cell-cycle element (CCE) required for…”
Get full text
Journal Article -
7
A role for regulated binding of p150(Glued) to microtubule plus ends in organelle transport
Published in The Journal of cell biology (22-07-2002)“…A subset of microtubule-associated proteins, including cytoplasmic linker protein (CLIP)-170, dynactin, EB1, adenomatous polyposis coli, cytoplasmic dynein,…”
Get full text
Journal Article -
8
Purification and Functional Analysis of a Novel Leucine-Zipper/Nucleotide-Fold Protein, BZAP45, Stimulating Cell Cycle Regulated Histone H4 Gene Transcription
Published in Biochemistry (Easton) (04-09-2001)“…Regulation of histone gene transcription at the G1/S phase transition via the Site II cell cycle control element is distinct from E2F-dependent mechanisms…”
Get full text
Journal Article -
9
A Role for Regulated Binding of p150Glued to Microtubule Plus Ends in Organelle Transport
Published in The Journal of cell biology (22-07-2002)“…A subset of microtubule-associated proteins, including cytoplasmic linker protein (CLIP)-170, dynactin, EB1, adenomatous polyposis coli, cytoplasmic dynein,…”
Get full text
Journal Article -
10
Cytoplasmic Dynein Intermediate Chain Phosphorylation Regulates Binding to Dynactin
Published in The Journal of biological chemistry (13-07-2001)“…Previously, we identified dynactin as a cargo receptor or adaptor for cytoplasmic dynein, mediated by an interaction between the dynein intermediate chain and…”
Get full text
Journal Article -
11
Polo-like Kinase1 Is Required for Recruitment of Dynein to Kinetochores during Mitosis
Published in The Journal of biological chemistry (10-06-2011)“…Kinetochore dynein has been implicated in microtubule capture, correcting inappropriate microtubule attachments, chromosome movement, and checkpoint silencing…”
Get full text
Journal Article -
12
Cell Cycle Regulation of Histone H4 Gene Transcription Requires the Oncogenic Factor IRF-2
Published in The Journal of biological chemistry (02-01-1998)“…Histone genes display a peak in transcription in early S phase and are ideal models for cell cycle-regulated gene expression. We have previously shown that the…”
Get full text
Journal Article -
13
The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes
Published in Molecular biology reports (01-01-1998)“…Maximal transcription of a prototypical cell cycle controlled histone H4 gene requires a proliferation-specific in vivo genomic protein/DNA interaction…”
Get full text
Journal Article -
14
Transfection‐induced defects in dynein‐driven transport: evidence that ICs mediate cargo‐binding
Published in Cell motility and the cytoskeleton (01-02-2009)“…Cytoplasmic dynein contributes to the localization and transport of multiple membranous organelles, including late endosomes, lysosomes, and the Golgi complex…”
Get full text
Journal Article -
15
Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme
Published in The Journal of biological chemistry (15-06-1991)“…DNA polymerase III holoenzyme (holoenzyme), the multiprotein replicase of Escherichia coli, is essentially unlimited in processive DNA synthesis. Processive…”
Get full text
Journal Article -
16
Cytoplasmic Dynein Intermediate Chain Phosphorylation Regulates Binding to Dynactin210
Published in The Journal of biological chemistry (13-07-2001)“…Previously, we identified dynactin as a cargo receptor or adaptor for cytoplasmic dynein, mediated by an interaction between the dynein intermediate chain and…”
Get full text
Journal Article -
17
A role for regulated binding of p150 Glued to microtubule plus ends in organelle transport
Published in The Journal of cell biology (22-07-2002)“…A subset of microtubule-associated proteins, including cytoplasmic linker protein (CLIP)-170, dynactin, EB1, adenomatous polyposis coli, cytoplasmic dynein,…”
Get full text
Journal Article -
18
DNA polymerase III accessory proteins. V. Theta encoded by holE
Published in The Journal of biological chemistry (05-06-1993)“…The polIII core subassembly of DNA polymerase III holoenzyme is composed of the alpha (DNA polymerase), epsilon (editing exonuclease), and theta subunits. We…”
Get full text
Journal Article -
19
Constitution of the twin polymerase of DNA polymerase III holoenzyme
Published in The Journal of biological chemistry (15-10-1991)“…It is speculated that DNA polymerases which duplicate chromosomes are dimeric to provide concurrent replication of both leading and lagging strands. DNA…”
Get full text
Journal Article -
20
Interferon regulatory factors : growth control and histone gene regulation : it's not just interferon anymore
Published in Journal of molecular medicine (Berlin, Germany) (01-05-1997)“…Interferon-regulatory factors (IRFs) are a related family of proteins originally identified by their ability to bind a DNA sequence found in the…”
Get full text
Conference Proceeding Journal Article