Search Results - "Vaughan, Laura K."

Genetic Variation in NCAM1 Contributes to Left Ventricular Wall Thickness in Hypertensive Families by Arnett, Donna K, Meyers, Kristin J, Devereux, Richard B, Tiwari, Hemant K, Gu, Charles C, Vaughan, Laura K, Perry, Rodney T, Patki, Amit, Claas, Steven A, Sun, Yan V, Broeckel, Ulrich, Kardia, Sharon L

“…RATIONALE:Left ventricular (LV) mass and related phenotypes are heritable, important predictors of cardiovascular disease, particularly in hypertensive…”
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Is Dietary Fat “Fattening”? A Comprehensive Research Synthesis by Shikany, James M, Vaughan, Laura K, Baskin, Monica L, Cope, Mark B, Hill, James O, Allison, David B

“…The goal of this research synthesis was to separate and articulate questions that had clear meaning, were empirically addressable, and were germane to the…”
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Molecular and Functional Networks Linked to Sarcopenia Prevention by Caloric Restriction in Rhesus Monkeys by Rhoads, Timothy W, Clark, Josef P, Gustafson, Grace E, Miller, Karl N, Conklin, Matthew W, DeMuth, Tyler M, Berres, Mark E, Eliceiri, Kevin W, Vaughan, Laura K, Lary, Christine W, Beasley, T Mark, Colman, Ricki J, Anderson, Rozalyn M

“…Caloric restriction (CR) improves survival in nonhuman primates and delays the onset of age-related morbidities including sarcopenia, which is characterized by…”
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Problems with Genome-Wide Association Studies by Shriner, Daniel, Vaughan, Laura K., Padilla, Miguel A., Tiwari, Hemant K., Williams, Scott M., Canter, Jeffrey A., Crawford, Dana C., Moore, Jason H., Ritchie, Marylyn D., Haines, Jonathan L.

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Commonality of functional annotation: a method for prioritization of candidate genes from genome-wide linkage studies by Shriner, Daniel, Baye, Tesfaye M, Padilla, Miguel A, Zhang, Shiju, Vaughan, Laura K, Loraine, Ann E

“…Linkage studies of complex traits frequently yield multiple linkage regions covering hundreds of genes. Testing each candidate gene from every region is…”
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Where in the genome are we? A cautionary tale of database use in genomics research by Vaughan, Laura K, Srinivasasainagendra, Vinodh

“…With the advent of high throughput data genomic technologies the volume of available data is now staggering. In addition databases that provide resources to…”
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Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men by Irvin, Marguerite R, Shrestha, Sadeep, Chen, Yii-Der I, Wiener, Howard W, Haritunians, Talin, Vaughan, Laura K, Tiwari, Hemant K, Taylor, Kent D, Scherzer, Rebecca, Saag, Michael S, Grunfeld, Carl, Rotter, Jerome I, Arnett, Donna K

“…OBJECTIVEGenetic studies may help explain abnormalities of fat distribution in HIV-infected patients treated with antiretroviral therapy (ARV)…”
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Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup'ik people by Aslibekyan, Stella, Vaughan, Laura K, Wiener, Howard W, Hidalgo, Bertha A, Lemas, Dominick J, O'Brien, Diane M, Hopkins, Scarlett E, Stanhope, Kimber L, Havel, Peter J, Thummel, Kenneth E, Boyer, Bert B, Tiwari, Hemant K

“…Vitamin D deficiency is a well-documented public health issue with both genetic and environmental determinants. Populations living at far northern latitudes…”
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The use of plasmodes as a supplement to simulations: A simple example evaluating individual admixture estimation methodologies by Vaughan, Laura K., Divers, Jasmin, Padilla, Miguel A., Redden, David T., Tiwari, Hemant K., Pomp, Daniel, Allison, David B.

“…With the advent of powerful computers, simulation studies are becoming an important tool in statistical methodology research. However, computer simulations of…”
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Gene expression patterns in peripheral blood cells associated with radiographic severity in African Americans with early rheumatoid arthritis by Reynolds, Richard J., Cui, Xiangqin, Vaughan, Laura K., Redden, David T., Causey, Zenoria, Perkins, Elizabeth, Shah, Tishi, Hughes, Laura B., Damle, Aarti, Kern, Marlena, Gregersen, Peter K., Johnson, Martin R., Bridges, S. Louis

“…Gene expression profiling may be used to stratify patients by disease severity to test the hypothesis that variable disease outcome has a genetic component. In…”
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Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles by Tiwari, Hemant K, Barnholtz-Sloan, Jill, Wineinger, Nathan, Padilla, Miguel A, Vaughan, Laura K, Allison, David B

“…When two or more populations have been separated by geographic or cultural boundaries for many generations, drift, spontaneous mutations, differential…”
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Correcting for Measurement Error in Individual Ancestry Estimates in Structured Association Tests by Divers, Jasmin, Vaughan, Laura K, Padilla, Miguel A, Fernandez, Jose R, Allison, David B, Redden, David T

“…We present theoretical explanations and show through simulation that the individual admixture proportion estimates obtained by using ancestry informative…”
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Comparing self-reported ethnicity to genetic background measures in the context of the Multi-Ethnic Study of Atherosclerosis (MESA) by Divers, Jasmin, Redden, David T, Rice, Kenneth M, Vaughan, Laura K, Padilla, Miguel A, Allison, David B, Bluemke, David A, Young, Hunter J, Arnett, Donna K

“…Questions remain regarding the utility of self-reported ethnicity (SRE) in genetic and epidemiologic research. It is not clear whether conditioning on SRE…”
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Characterization of autosomal copy-number variation in African Americans: the HyperGEN Study by WINEINGER, Nathan E, PAJEWSKI, Nicholas M, ARNETT, Donna K, TIWARI, Hemant K, KENNEDY, Richard E, WOJCZYNSKI, Mary K, VAUGHAN, Laura K, HUNT, Steven C, CHARLES GU, C, RAO, Dabeeru C, LORIER, Rachel, BROECKEL, Ulrich

“…African Americans are a genetically diverse population with a high burden of many, common heritable diseases. However, our understanding of genetic variation…”
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Multiple imputation to correct for measurement error in admixture estimates in genetic structured association testing by Padilla, Miguel A, Divers, Jasmin, Vaughan, Laura K, Allison, David B, Tiwari, Hemant K

“…Structured association tests (SAT), like any statistical model, assumes that all variables are measured without error. Measurement error can bias parameter…”
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Genetic region characterization (Gene RECQuest) - software to assist in identification and selection of candidate genes from genomic regions by Sadasivam, Rajani S, Sundar, Gayathri, Vaughan, Laura K, Tanik, Murat M, Arnett, Donna K

“…The availability of research platforms like the web tools of the National Center for Biotechnology Information (NCBI) has transformed the time-consuming task…”
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A unified framework for multi-locus association analysis of both common and rare variants by Shriner, Daniel, Vaughan, Laura Kelly

“…Common, complex diseases are hypothesized to result from a combination of common and rare genetic variants. We developed a unified framework for the joint…”
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RYR3 gene polymorphisms and cardiovascular disease outcomes in the context of antihypertensive treatment by Lynch, A I, Irvin, M R, Boerwinkle, E, Davis, B R, Vaughan, L K, Ford, C E, Aissani, B, Eckfeldt, J H, Arnett, D K, Shrestha, S

“…Nearly one-third of adults in the United States have hypertension, which is associated with increased cardiovascular disease (CVD) morbidity and mortality. The…”
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Commonality of functional annotation: a method for prioritization of candidate genes from genome-wide linkage studies super() by Shriner, Daniel, Baye, Tesfaye M, Padilla, Miguel A, Zhang, Shiju, Vaughan, Laura K, Loraine, Ann E

“…Linkage studies of complex traits frequently yield multiple linkage regions covering hundreds of genes. Testing each candidate gene from every region is…”
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The use of plasmodes as a supplement to simulations : A simple example evaluating individual admixture estimation methodologies: Statistical Genetics & Statistical Genomics: Where Biology, Epistemology, Statistics, and Computation Collide by VAUGHAN, Laura K, DIVERS, Jasmin, PADILLA, Miguel A, REDDEN, David T, TIWARI, Hemant K, POMP, Daniel, ALLISON, David B

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