Search Results - "Vaughan, Hannah J."

Cancer‐Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery by Vaughan, Hannah J., Green, Jordan J., Tzeng, Stephany Y.

“…Nucleic acids are a promising type of therapeutic for the treatment of a wide range of conditions, including cancer, but they also pose many delivery…”
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Biodegradable Polymeric Nanoparticles for Therapeutic Cancer Treatments by Karlsson, Johan, Vaughan, Hannah J, Green, Jordan J

“…Polymeric nanoparticles have tremendous potential to improve the efficacy of therapeutic cancer treatments by facilitating targeted delivery to a desired site…”
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High-throughput evaluation of polymeric nanoparticles for tissue-targeted gene expression using barcoded plasmid DNA by Kim, Jayoung, Vaughan, Hannah J., Zamboni, Camila G., Sunshine, Joel C., Green, Jordan J.

“…Successful systemic gene delivery requires specific tissue targeting as well as efficient intracellular transfection. Increasingly, research laboratories are…”
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A high-throughput lysosome trafficking assay guides ligand selection and elucidates differences in CD22-targeted nanodelivery by Vaughan, Hannah J, Est-Witte, Savannah, Dockery, Lance T, Urello, Morgan A, Boyd, Jonathan, Keyser, Brittany D, Zhuang, Li, Marelli, Marcello, Christie, R James

“…Targeted nanoparticles offer potential to selectively deliver therapeutics to cells; however, their subcellular fate following endocytosis must be understood…”
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Poly(beta-amino ester) nanoparticles enable tumor-specific TRAIL secretion and a bystander effect to treat liver cancer by Vaughan, Hannah J., Zamboni, Camila G., Radant, Nicholas P., Bhardwaj, Pranshu, Revai Lechtich, Esther, Hassan, Laboni F., Shah, Khalid, Green, Jordan J.

“…Despite initial promise, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based approaches to cancer treatment have yet to yield a clinically…”
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Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo by Kozielski, Kristen L., Ruiz-Valls, Alejandro, Tzeng, Stephany Y., Guerrero-Cázares, Hugo, Rui, Yuan, Li, Yuxin, Vaughan, Hannah J., Gionet-Gonzales, Marissa, Vantucci, Casey, Kim, Jayoung, Schiapparelli, Paula, Al-Kharboosh, Rawan, Quiñones-Hinojosa, Alfredo, Green, Jordan J.

“…Novel treatments for glioblastoma (GBM) are urgently needed, particularly those which can simultaneously target GBM cells’ ability to grow and migrate. Herein,…”
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Polymeric nanoparticles as cancer-specific DNA delivery vectors to human hepatocellular carcinoma by Zamboni, Camila G., Kozielski, Kristen L., Vaughan, Hannah J., Nakata, Maisa M., Kim, Jayoung, Higgins, Luke J., Pomper, Martin G., Green, Jordan J.

“…Hepatocellular carcinoma (HCC) is the third most deadly cancer in the US, with a meager 5-year survival rate of <20%. Such unfavorable numbers are closely…”
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Recent advances in gene therapy for cancer theranostics by Vaughan, Hannah J., Green, Jordan J.

“…There is great interest in developing gene therapies for many disease indications, including cancer. However, successful delivery of nucleic acids to tumor…”
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Polymeric nanoparticles for dual-targeted theranostic gene delivery to hepatocellular carcinoma by Vaughan, Hannah J, Zamboni, Camila G, Hassan, Laboni F, Radant, Nicholas P, Jacob, Desmond, Mease, Ronnie C, Minn, Il, Tzeng, Stephany Y, Gabrielson, Kathleen L, Bhardwaj, Pranshu, Guo, Xin, Francisco, David, Pomper, Martin G, Green, Jordan J

“…Hepatocellular carcinoma (HCC) develops predominantly in the inflammatory environment of a cirrhotic liver caused by hepatitis, toxin exposure, or chronic…”
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Non-Viral Gene Delivery to Hepatocellular Carcinoma via Intra-Arterial Injection by Vaughan, Hannah J, Zamboni, Camila G, Luly, Kathryn M, Li, Ling, Gabrielson, Kathleen L, Hassan, Laboni F, Radant, Nicholas P, Bhardwaj, Pranshu, Selaru, Florin M, Pomper, Martin G, Green, Jordan J

“…Hepatocellular carcinoma (HCC) has limited treatment options, and modest survival after systemic chemotherapy or procedures such as transarterial…”
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