Search Results - "Vatner, Ralph E"

Combinations of immunotherapy and radiation in cancer therapy by Vatner, Ralph E, Cooper, Benjamin T, Vanpouille-Box, Claire, Demaria, Sandra, Formenti, Silvia C

“…The immune system has the ability to recognize and specifically reject tumors, and tumors only become clinically apparent once they have evaded immune…”
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Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model by Williams, Michael T, Sugimoto, Chiho, Regan, Samantha L, Pitzer, Emily M, Fritz, Adam L, Sertorio, Mathieu, Mascia, Anthony E, Vatner, Ralph E, Perentesis, John P, Vorhees, Charles V

“…Recent studies suggest that ultra-high dose rates of proton radiation (>40 Gy/s; FLASH) confer less toxicity to exposed healthy tissue and reduce cognitive…”
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Harnessing the cGAS-STING pathway to potentiate radiation therapy: current approaches and future directions by Colangelo, Nicholas W, Gerber, Naamit K, Vatner, Ralph E, Cooper, Benjamin T

“…In this review, we cover the current understanding of how radiation therapy, which uses ionizing radiation to kill cancer cells, mediates an anti-tumor immune…”
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Whole brain proton irradiation in adult Sprague Dawley rats produces dose dependent and non-dependent cognitive, behavioral, and dopaminergic effects by Williams, Michael T., Sugimoto, Chiho, Regan, Samantha L., Pitzer, Emily M., Fritz, Adam L., Mascia, Anthony E., Sertorio, Mathieu, Vatner, Ralph E., Perentesis, John P., Vorhees, Charles V.

“…Proton radiotherapy causes less off-target effects than X-rays but is not without effect. To reduce adverse effects of proton radiotherapy, a model of…”
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Myeloid-Derived Cells in Tumors: Effects of Radiation by Vatner, Ralph E., MD, PhD, Formenti, Silvia C., MD

“…The discrepancy between the in vitro and in vivo response to radiation is readily explained by the fact that tumors do not exist independently of the host…”
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STING, DCs and the link between innate and adaptive tumor immunity by Vatner, Ralph E., Janssen, Edith M.

“…•Dendritic cells (DCs) serve as the cellular link between innate and adaptive anti-tumor immunity.•DCs are essential for cross-priming adaptive T cell…”
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Extraneural recurrence of an intracranial nongerminomatous germ cell tumor to cervical lymph nodes in a pediatric patient: Case report by Howell, Jackson, Dandoy, Christopher, Wright, Jordan M., Chow, Lionel, El‐Sheikh, Ayman, Dole, Mukund, Vatner, Ralph E., Kamian, Kambiz

“…Background Intracranial germ cell tumors (GCTs) comprise 3%–5% of pediatric primary central nervous system (CNS) tumors in Western countries. Though they are…”
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Resection Followed by Involved-Field Fractionated Radiotherapy in the Management of Single Brain Metastasis by Shin, Samuel M, Vatner, Ralph E, Tam, Moses, Golfinos, John G, Narayana, Ashwatha, Kondziolka, Douglas, Silverman, Joshua Seth

“…We expanded upon our previous experience using involved-field fractionated radiotherapy (IFRT) as an alternative to whole brain radiotherapy or stereotactic…”
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Endocrine Deficiency As a Function of Radiation Dose to the Hypothalamus and Pituitary in Pediatric and Young Adult Patients With Brain Tumors by Vatner, Ralph E, Niemierko, Andrzej, Misra, Madhusmita, Weyman, Elizabeth A, Goebel, Claire P, Ebb, David H, Jones, Robin M, Huang, Mary S, Mahajan, Anita, Grosshans, David R, Paulino, Arnold C, Stanley, Takara, MacDonald, Shannon M, Tarbell, Nancy J, Yock, Torunn I

“…There are sparse data defining the dose response of radiation therapy (RT) to the hypothalamus and pituitary in pediatric and young adult patients with brain…”
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Sentinel lymph node biopsy in head and neck rhabdomyosarcoma by Turpin, Brian, Pressey, Joseph G., Nagarajan, Rajaram, Weiss, Brian D., Trout, Andrew T., Gelfand, Michael J., Pater, Luke, Vatner, Ralph E., Breneman, John C., Dasgupta, Roshni

“…Head and neck rhabdomyosarcoma lymph node staging is challenging due to varied patterns of lymphatic drainage and the suboptimal predictive value of available…”
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Practice Patterns Among Radiation Oncologists Treating Pediatric Patients With Proton Craniospinal Irradiation by Medek, Sara, De, Brian, Pater, Luke, Breneman, John, Mahajan, Anita, Wolden, Suzanne, Vatner, Ralph E

“…Craniospinal irradiation (CSI) is an important component of therapy for many pediatric central nervous system malignancies. Proton therapy is increasingly…”
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Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy by Sertorio, Mathieu, Perentesis, John P., Vatner, Ralph E., Mascia, Anthony E., Zheng, Yi, Wells, Susanne I.

“…Advances in radiation delivery technologies and immunotherapy have improved effective cancer treatments and long-term outcomes. Experimental and clinical…”
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The tailless complex polypeptide-1 ring complex of the heat shock protein 60 family facilitates cross-priming of CD8 responses specific for chaperoned peptides by Vatner, Ralph E, Srivastava, Pramod K

“…The tailless complex polypeptide-1 ring complex (TRiC) is a eukaryotic heat shock protein 60 (hsp60) molecule that has been shown to bind N-terminally extended…”
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Specific Immunogenicity of Heat Shock Protein gp96 Derives from Chaperoned Antigenic Peptides and Not from Contaminating Proteins by Binder, Robert J, Kelly, John B., III, Vatner, Ralph E, Srivastava, Pramod K

“…The peptide-binding property of MHC is central to adaptive immunological functions. A similar property of heat shock proteins (HSPs) hsp70 and hsp90 has been…”
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Cognitive and behavioral effects of whole brain conventional or high dose rate by Williams, Michael T, Sugimoto, Chiho, Regan, Samantha L, Pitzer, Emily M, Fritz, Adam L, Sertorio, Mathieu, Mascia, Anthony E, Vatner, Ralph E, Perentesis, John P, Vorhees, Charles V

“…Recent studies suggest that ultra-high dose rates of proton radiation (>40 Gy/s; FLASH) confer less toxicity to exposed healthy tissue and reduce cognitive…”
Get full text

3174: Effects of whole brain conventional or FLASH proton irradiation in Sprague Dawley rats by Vorhees, Charles V., Sugimoto, Chiho, Regan, Samantha L., Pitzer, Emily M., Fritz, Adam L., Gollaway, Brooke M., Sertorio, Mathieu, Mascia, Anthony E., Vatner, Ralph E., Parentesis, John P., Williams, Michael T.

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Abstract PO-009: Targeting a unique electrochemical vulnerability in a pediatric brain tumor to potentiate proton beam radiotherapy by Krummel, Daniel Pomeranz, Kallay, Laura, Bhattacharya, Debanjan, Gawali, Vaibhavkumar, Donatien, Kamdem T., Ahmed, Taukir, Cook, James M., Lamba, Michael, Wells, Susanne, Vatner, Ralph E., Sertorio, Mathieu, Ionascu, Dan T., Sengupta, Soma

“…Medulloblastoma (MB) is the most common malignant (WHO Grade IV) primary brain cancer in children, adolescents, and young adults. Radiotherapy (RT) is a…”
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RO-21A PROSPECTIVE ASSESSMENT OF HRQOL OUTCOMES IN MEDULLOBLASTOMA PATIENTS TREATED WITH PROTON RADIOTHERAPY (PT) by Yock, Torunn I., Goldberg, Saveli I., Vatner, Ralph E., Gaudet, Dillon E., Gallotto, Sara L., Weyman, Elizabeth A., MacDonald, Shannon M., Ebb, David H., Huang, Mary, Friedmann, Allison M., Jones, Robin M., Tarbell, Nancy J., Kuhlthau, Karen A.

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Extraneural recurrence of an intracranial nongerminomatous germ cell tumor to cervical lymph nodes in a pediatric patient: Case report by Howell, Jackson, Dandoy, Christopher, Wright, Jordan M, Chow, Lionel, El-Sheikh, Ayman, Dole, Mukund, Vatner, Ralph E, Kamian, Kambiz

“…BACKGROUNDIntracranial germ cell tumors (GCTs) comprise 3%-5% of pediatric primary central nervous system (CNS) tumors in Western countries. Though they are…”
Get full text