Search Results - "Vatine, Gad"

Parkinson's disease outside the brain: targeting the autonomic nervous system by Sharabi, Yehonatan, Vatine, Gad D, Ashkenazi, Avraham

“…Patients with Parkinson's disease present with signs and symptoms of dysregulation of the peripheral autonomic nervous system that can even precede motor…”
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Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications by Vatine, Gad D., Barrile, Riccardo, Workman, Michael J., Sances, Samuel, Barriga, Bianca K., Rahnama, Matthew, Barthakur, Sonalee, Kasendra, Magdalena, Lucchesi, Carolina, Kerns, Jordan, Wen, Norman, Spivia, Weston R., Chen, Zhaohui, Van Eyk, Jennifer, Svendsen, Clive N.

“…The blood-brain barrier (BBB) tightly regulates the entry of solutes from blood into the brain and is disrupted in several neurological diseases. Using…”
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SnapShot: Autonomic nervous system disorders by Sharabi, Yehonatan, Vatine, Gad D., Ashkenazi, Avraham

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Nano-scale architecture of blood-brain barrier tight-junctions by Sasson, Esther, Anzi, Shira, Bell, Batia, Yakovian, Oren, Zorsky, Meshi, Deutsch, Urban, Engelhardt, Britta, Sherman, Eilon, Vatine, Gad, Dzikowski, Ron, Ben-Zvi, Ayal

“…Tight junctions (TJs) between blood-brain barrier (BBB) endothelial cells construct a robust physical barrier, whose damage underlies BBB dysfunctions related…”
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An isogenic blood–brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells by Canfield, Scott G., Stebbins, Matthew J., Morales, Bethsymarie Soto, Asai, Shusaku W., Vatine, Gad D., Svendsen, Clive N., Palecek, Sean P., Shusta, Eric V.

“…The blood–brain barrier (BBB) is critical in maintaining a physical and metabolic barrier between the blood and the brain. The BBB consists of brain…”
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Altered behavioral performance and live imaging of circuit-specific neural deficiencies in a zebrafish model for psychomotor retardation by Zada, David, Tovin, Adi, Lerer-Goldshtein, Tali, Vatine, Gad David, Appelbaum, Lior

“…The mechanisms and treatment of psychomotor retardation, which includes motor and cognitive impairment, are indefinite. The Allan-Herndon-Dudley syndrome…”
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Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier by Vatine, Gad D., Al-Ahmad, Abraham, Barriga, Bianca K., Svendsen, Soshana, Salim, Ariel, Garcia, Leslie, Garcia, Veronica J., Ho, Ritchie, Yucer, Nur, Qian, Tongcheng, Lim, Ryan G., Wu, Jie, Thompson, Leslie M., Spivia, Weston R., Chen, Zhaohui, Van Eyk, Jennifer, Palecek, Sean P., Refetoff, Samuel, Shusta, Eric V., Svendsen, Clive N.

“…Inactivating mutations in the thyroid hormone (TH) transporter Monocarboxylate transporter 8 (MCT8) cause severe psychomotor retardation in children. Animal…”
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Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits by Lim, Ryan G., Quan, Chris, Reyes-Ortiz, Andrea M., Lutz, Sarah E., Kedaigle, Amanda J., Gipson, Theresa A., Wu, Jie, Vatine, Gad D., Stocksdale, Jennifer, Casale, Malcolm S., Svendsen, Clive N., Fraenkel, Ernest, Housman, David E., Agalliu, Dritan, Thompson, Leslie M.

“…Brain microvascular endothelial cells (BMECs) are an essential component of the blood-brain barrier (BBB) that shields the brain against toxins and immune…”
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Microfluidic channel sensory system for electro-addressing cell location, determining confluency, and quantifying a general number of cells by Rapier, Crystal E., Jagadeesan, Srikanth, Vatine, Gad, Ben-Yoav, Hadar

“…Microfluidics is a highly useful platform for culturing, monitoring, and testing biological cells. The integration of electrodes into microfluidic channels…”
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It’s time to swim! Zebrafish and the circadian clock by Vatine, Gad, Vallone, Daniela, Gothilf, Yoav, Foulkes, Nicholas S.

“…The zebrafish represents a fascinating model for studying key aspects of the vertebrate circadian timing system. Easy access to early embryonic development has…”
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Chronic and acute exposure to rotenone reveals distinct Parkinson's disease-related phenotypes in human iPSC-derived peripheral neurons by Saleh, Mahmood Ali, Amer-Sarsour, Fatima, Berant, Asaf, Pasmanik-Chor, Metsada, Kobo, Hila, Sharabi, Yehonatan, Vatine, Gad D., Ashkenazi, Avraham

“…Peripheral autonomic nervous system (P-ANS) dysfunction is a critical non-motor phenotype of Parkinson's disease (PD). The majority of PD cases are sporadic…”
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PLEKHM2 Loss of Function Impairs the Activity of iPSC-Derived Neurons via Regulation of Autophagic Flux by Ben-Zvi, Hadas, Rabinski, Tatiana, Ofir, Rivka, Cohen, Smadar, Vatine, Gad D

“…Pleckstrin Homology And RUN Domain Containing M2 (PLEKHM2) [delAG] mutation causes dilated cardiomyopathy with left ventricular non-compaction (DCM-LVNC),…”
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Introducing ADNP and SIRT1 as new partners regulating microtubules and histone methylation by Hadar, Adva, Kapitansky, Oxana, Ganaiem, Maram, Sragovich, Shlomo, Lobyntseva, Alexandra, Giladi, Eliezer, Yeheskel, Adva, Avitan, Aliza, Vatine, Gad D., Gurwitz, David, Ivashko-Pachima, Yanina, Gozes, Illana

“…Activity-dependent neuroprotective protein (ADNP) is essential for brain formation and function. As such, de novo mutations in ADNP lead to the autistic ADNP…”
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Disease-associated polyalanine expansion mutations impair UBA6-dependent ubiquitination by Amer-Sarsour, Fatima, Falik, Daniel, Berdichevsky, Yevgeny, Kordonsky, Alina, Eid, Sharbel, Rabinski, Tatiana, Ishtayeh, Hasan, Cohen-Adiv, Stav, Braverman, Itzhak, Blumen, Sergiu C, Laviv, Tal, Prag, Gali, Vatine, Gad D, Ashkenazi, Avraham

“…Expansion mutations in polyalanine stretches are associated with a growing number of diseases sharing a high degree of genotypic and phenotypic commonality…”
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Genetic ablation of hypocretin neurons alters behavioral state transitions in zebrafish by Elbaz, Idan, Yelin-Bekerman, Laura, Nicenboim, Julian, Vatine, Gad, Appelbaum, Lior

“…Sleep is an essential biological need of all animals studied to date. The sleep disorder narcolepsy is characterized by excessive daytime sleepiness,…”
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Impedance Characteristics of Microfluidic Channels and Integrated Coplanar Parallel Electrodes as Design Parameters for Whole-Channel Analysis in Organ-on-Chip Micro-Systems by Rapier, Crystal E, Jagadeesan, Srikanth, Vatine, Gad D, Ben-Yoav, Hadar

“…Microfluidics have revolutionized cell culture by allowing for precise physical and chemical environmental control. Coupled with electrodes, microfluidic cell…”
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Oligodendrocyte progenitor cell maturation is dependent on dual function of MCT8 in the transport of thyroid hormone across brain barriers and the plasma membrane by Vatine, Gad D., Shelest, Oksana, Barriga, Bianca K., Ofan, Raz, Rabinski, Tatyana, Mattis, Virginia B., Heuer, Heike, Svendsen, Clive N.

“…Inactivating mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8) causes a rare and debilitating form of X‐linked psychomotor…”
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Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development by Sances, Samuel, Ho, Ritchie, Vatine, Gad, West, Dylan, Laperle, Alex, Meyer, Amanda, Godoy, Marlesa, Kay, Paul S., Mandefro, Berhan, Hatata, Seigo, Hinojosa, Chris, Wen, Norman, Sareen, Dhruv, Hamilton, Geraldine A., Svendsen, Clive N.

“…Human stem cell-derived models of development and neurodegenerative diseases are challenged by cellular immaturity in vitro. Microengineered organ-on-chip (or…”
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AAV9-MCT8 Delivery at Juvenile Stage Ameliorates Neurological and Behavioral Deficits in a Mouse Model of MCT8-Deficiency by Liao, Xiao-Hui, Avalos, Pablo, Shelest, Oksana, Ofan, Raz, Shilo, Michael, Bresee, Catherine, Likhite, Shibi, Vit, Jean-Philippe, Heuer, Heike, Kaspar, Brian, Meyer, Kathrin, Dumitrescu, Alexandra M, Refetoff, Samuel, Svendsen, Clive N, Vatine, Gad D

“…Allan-Herndon-Dudley syndrome (AHDS) is a severe psychomotor disability disorder that also manifests characteristic abnormal thyroid hormone (TH) levels. AHDS…”
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The light-induced transcriptome of the zebrafish pineal gland reveals complex regulation of the circadian clockwork by light by Ben-Moshe, Zohar, Alon, Shahar, Mracek, Philipp, Faigenbloom, Lior, Tovin, Adi, Vatine, Gad D, Eisenberg, Eli, Foulkes, Nicholas S, Gothilf, Yoav

“…Light constitutes a primary signal whereby endogenous circadian clocks are synchronized ('entrained') with the day/night cycle. The molecular mechanisms…”
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