Efficacy of assisted reproductive technology after ovarian tissue transplantation in a cohort of 11 patients with or without associated infertility factors

Purpose IVF treatment in women with grafted frozen-thawed ovarian tissue is associated with poor reproductive outcomes. The aim of this study was to evaluate the efficacy of ovarian tissue transplantation (OTT) followed by assisted reproductive technology (ART) in women with or without associated in...

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Bibliographic Details
Published in:	Journal of assisted reproduction and genetics Vol. 38; no. 2; pp. 503 - 511
Main Authors:	Vatel, M., Torre, A., Paillusson, B., Scheffler, F., Bergere, M., Benkhalifa, M., Le Martelot, M.-T., Leperlier, F., Mirallié, S., Selleret, L., Prades-Borio, M., Neuraz, A., Barraud-Lange, V., Boissel, N., Fortin, A., Poirot, C.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-02-2021 Springer Nature B.V Springer Verlag
Subjects:	Adult Birth Rate Cohort Studies Embryo transfer Embryo Transfer - methods Embryos Female Fertility Preservation Fertilization in Vitro Gynecology Human Genetics Humans In vitro fertilization Infertility Infertility, Female - pathology Infertility, Female - therapy Life Sciences Live Birth - epidemiology Medicine Medicine & Public Health Oocyte Retrieval - methods Oocytes Ovarian Follicle - pathology Ovarian Follicle - transplantation Ovaries Ovulation Induction Pregnancy Reproductive Medicine Reproductive Techniques, Assisted Reproductive technologies Reproductive technology Sperm Injections, Intracytoplasmic Transplantation Pregnancy Ovarian tissue cryopreservation Assisted reproductive technology Live birth Ovarian tissue transplantation Infertility
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Summary:	Purpose IVF treatment in women with grafted frozen-thawed ovarian tissue is associated with poor reproductive outcomes. The aim of this study was to evaluate the efficacy of ovarian tissue transplantation (OTT) followed by assisted reproductive technology (ART) in women with or without associated infertility factors. Methods This is a prospective cohort study with retrospective data collection including eleven women, four of whom having an infertility factor (IF), who had undergone OTT in one university center between 2005 and 2017, followed by ART in six in vitro fertilization (IVF) centers. Results In total, 25 of the 85 cycles initiated (29%) were canceled, resulting in 60 oocyte retrievals. Ninety-five oocytes were retrieved: 36 were abnormal or immature, 29/39 fertilized (74%) after ICSI and 13/20 (65%) after IVF. Thirty-five embryos were transferred in seven patients (5/7 patients without IF and 2/4 patients with IF). After ART, one patient with IF experienced two pregnancies, one resulting in a live birth. For all patients, pregnancy rates and live birth rates were 7.4% and 3.7% per embryo transfer, respectively. Nine pregnancies and four live births occurred after spontaneous conception in five patients without IF, none in the infertility group. Conclusion This study confirms that IVF treatment in women with grafted frozen-thawed ovarian tissue is associated with poor outcomes. However, the chances of natural conception are high in women without IF. Patients with IF, without the possibility of spontaneous pregnancy, should be informed of poor reproductive outcomes after OTT followed by ART. Trial registration number NCT02184806
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1058-0468 1573-7330 1573-7330
DOI:	10.1007/s10815-020-02033-9