Search Results - "Vassiliki, Saloura"

Critical roles of non-histone protein lysine methylation in human tumorigenesis by Hamamoto, Ryuji, Saloura, Vassiliki, Nakamura, Yusuke

“…Key Points Lysine methylation is widely recognized as a fundamental post-translational modification. Most protein lysine methyltransferases (PKMTs) contain the…”
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Epigenetic modulation of immunotherapy and implications in head and neck cancer by Zhou, Liye, Xu, Na, Shibata, Hirofumi, Saloura, Vassiliki, Uppaluri, Ravindra

“…Cancer progression is facilitated by distinct mechanisms developed by cancer cells to avoid immune recognition and clearance. The clinical application of…”
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The NSD family of protein methyltransferases in human cancer by Vougiouklakis, Theodore, Hamamoto, Ryuji, Nakamura, Yusuke, Saloura, Vassiliki

“…The NSD family of protein lysine methyltransferases consists of NSD1, NSD2/WHSC1/MMSET and NSD3/WHSC1L1. NSD2 haploinsufficiency causes Wolf-Hirschhorn…”
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SMYD3: a regulator of epigenetic and signaling pathways in cancer by Bernard, Benjamin J, Nigam, Nupur, Burkitt, Kyunghee, Saloura, Vassiliki

“…Chromatin modifiers and their implications in oncogenesis have been an exciting area of cancer research. These are enzymes that modify chromatin via…”
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Integrative analysis reveals early epigenetic alterations in high-grade serous ovarian carcinomas by Machino, Hidenori, Dozen, Ai, Konaka, Mariko, Komatsu, Masaaki, Nakamura, Kohei, Ikawa, Noriko, Shozu, Kanto, Asada, Ken, Kaneko, Syuzo, Yoshida, Hiroshi, Kato, Tomoyasu, Nakayama, Kentaro, Saloura, Vassiliki, Kyo, Satoru, Hamamoto, Ryuji

“…High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological malignancy. To date, the profiles of gene mutations and copy number alterations in…”
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WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck by Saloura, Vassiliki, Cho, Hyun-Soo, Kiyotani, Kazuma, Alachkar, Houda, Zuo, Zhixiang, Nakakido, Makoto, Tsunoda, Tatsuhiko, Seiwert, Tanguy, Lingen, Mark, Licht, Jonathan, Nakamura, Yusuke, Hamamoto, Ryuji

“…Squamous cell carcinoma of the head and neck (SCCHN) is a relatively common malignancy with suboptimal long-term prognosis, thus new treatment strategies are…”
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Critical roles of protein methyltransferases and demethylases in the regulation of embryonic stem cell fate by Vougiouklakis, Theodore, Nakamura, Yusuke, Saloura, Vassiliki

“…Accumulating evidence has recently shown that protein methyltransferases and demethylases are crucial regulators in either maintaining pluripotent states or…”
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WHSC1 monomethylates histone H1 and induces stem-cell like features in squamous cell carcinoma of the head and neck by Saloura, Vassiliki, Vougiouklakis, Theodore, Bao, Riyue, Kim, Sohyoung, Baek, Songjoon, Zewde, Makda, Bernard, Benjamin, Burkitt, Kyunghee, Nigam, Nupur, Izumchenko, Evgeny, Dohmae, Naoshi, Hamamoto, Ryuji, Nakamura, Yusuke

“…Squamous cell carcinoma of the head and neck (SCCHN) is a malignancy with poor outcomes, thus novel therapies are urgently needed. We recently showed that…”
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WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer by Saloura, Vassiliki, Vougiouklakis, Theodore, Zewde, Makda, Deng, Xiaolan, Kiyotani, Kazuma, Park, Jae-Hyun, Matsuo, Yo, Lingen, Mark, Suzuki, Takehiro, Dohmae, Naoshi, Hamamoto, Ryuji, Nakamura, Yusuke

“…While multiple post-translational modifications have been reported to regulate the function of epidermal growth factor receptor (EGFR), the effect of protein…”
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Characterization of the T-Cell Receptor Repertoire and Immune Microenvironment in Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck by Saloura, Vassiliki, Fatima, Aiman, Zewde, Makda, Kiyotani, Kazuma, Brisson, Ryan, Park, Jae-Hyun, Ikeda, Yuji, Vougiouklakis, Theodore, Bao, Riyue, Khattri, Arun, Seiwert, Tanguy, Cipriani, Nicole, Lingen, Mark, Vokes, Everett, Nakamura, Yusuke

“…Squamous cell carcinoma of the head and neck (SCCHN) is a lethal cancer with a suboptimal 5-year overall survival of approximately 50% with surgery and/or…”
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Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations by Kaneko, Syuzo, Takasawa, Ken, Asada, Ken, Shiraishi, Kouya, Ikawa, Noriko, Machino, Hidenori, Shinkai, Norio, Matsuda, Maiko, Masuda, Mari, Adachi, Shungo, Takahashi, Satoshi, Kobayashi, Kazuma, Kouno, Nobuji, Bolatkan, Amina, Komatsu, Masaaki, Yamada, Masayoshi, Miyake, Mototaka, Watanabe, Hirokazu, Tateishi, Akiko, Mizuno, Takaaki, Okubo, Yu, Mukai, Masami, Yoshida, Tatsuya, Yoshida, Yukihiro, Horinouchi, Hidehito, Watanabe, Shun-Ichi, Ohe, Yuichiro, Yatabe, Yasushi, Saloura, Vassiliki, Kohno, Takashi, Hamamoto, Ryuji

“…In an extensive genomic analysis of lung adenocarcinomas (LUADs), driver mutations have been recognized as potential targets for molecular therapy. However,…”
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Identification of neoantigen-specific T cells and their targets: implications for immunotherapy of head and neck squamous cell carcinoma by Ren, Lili, Leisegang, Matthias, Deng, Boya, Matsuda, Tatsuo, Kiyotani, Kazuma, Kato, Taigo, Harada, Makiko, Park, Jae-Hyun, Saloura, Vassiliki, Seiwert, Tanguy, Vokes, Everett, Agrawal, Nishant, Nakamura, Yusuke

“…To develop a practically applicable method for T-cell receptor (TCR)-engineered T cell immunotherapy targeting neoantigens, we have been attempting to identify…”
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SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck by Nigam, Nupur, Bernard, Benjamin, Sevilla, Samantha, Kim, Sohyoung, Dar, Mohd Saleem, Tsai, Daniel, Robbins, Yvette, Burkitt, Kyunghee, Sievers, Cem, Allen, Clint T., Bennett, Richard L., Tettey, Theophilus T., Carter, Benjamin, Rinaldi, Lorenzo, Lingen, Mark W., Sater, Houssein, Edmondson, Elijah F., Moshiri, Arfa, Saeed, Abbas, Cheng, Hui, Luo, Xiaolin, Brennan, Kevin, Koparde, Vishal, Chen, Chen, Das, Sudipto, Andresson, Thorkell, Abdelmaksoud, Abdalla, Murali, Madhavi, Sakata, Seiji, Takeuchi, Kengo, Chari, Raj, Nakamura, Yusuke, Uppaluri, Ravindra, Sunwoo, John B., Van Waes, Carter, Licht, Jonathan D., Hager, Gordon L., Saloura, Vassiliki

“…Cancers often display immune escape, but the mechanisms are incompletely understood. Herein, we identify SMYD3 as a mediator of immune escape in human…”
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The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma by Machino, Hidenori, Kaneko, Syuzo, Komatsu, Masaaki, Ikawa, Noriko, Asada, Ken, Nakato, Ryuichiro, Shozu, Kanto, Dozen, Ai, Sone, Kenbun, Yoshida, Hiroshi, Kato, Tomoyasu, Oda, Katsutoshi, Osuga, Yutaka, Fujii, Tomoyuki, von Keudell, Gottfried, Saloura, Vassiliki, Hamamoto, Ryuji

“…High-grade serous ovarian carcinoma (HGSOC) is the most aggressive gynecological malignancy, resulting in approximately 70% of ovarian cancer deaths. However,…”
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SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells by Vougiouklakis, Theodore, Sone, Kenbun, Saloura, Vassiliki, Cho, Hyun-Soo, Suzuki, Takehiro, Dohmae, Naoshi, Alachkar, Houda, Nakamura, Yusuke, Hamamoto, Ryuji

“…The oncogenic protein ERK, a member of the extracellular signal-regulated kinase (ERK) cascade, is a well characterized signaling molecule involved in…”
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WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck by Saloura, Vassiliki, Vougiouklakis, Theodore, Zewde, Makda, Kiyotani, Kazuma, Park, Jae-Hyun, Gao, Guimin, Karrison, Theodore, Lingen, Mark, Nakamura, Yusuke, Hamamoto, Ryuji

“…Wolf-Hisrchhorn Syndrome Candidate 1-Like 1 (WHSC1L1) is a protein lysine methyltransferase that is recurrently amplified (8p11.23) in patients with squamous…”
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Ex vivo antibody-dependent cellular cytotoxicity inducibility predicts efficacy of cetuximab by Taylor, Rodney J, Saloura, Vassiliki, Jain, Ajay, Goloubeva, Olga, Wong, Stuart, Kronsberg, Shari, Nagilla, Madhavi, Silpino, Lorna, de Souza, Jonas, Seiwert, Tanguy, Vokes, Everett, Villaflor, Victoria, Cohen, Ezra E W

“…We conducted in vitro studies and a clinical trial for patients with squamous cell carcinoma of the head and neck (SCCHN) to study the relationship between…”
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p53-independent p21 induction by MELK inhibition by Matsuda, Tatsuo, Kato, Taigo, Kiyotani, Kazuma, Tarhan, Yunus Emre, Saloura, Vassiliki, Chung, Suyoun, Ueda, Koji, Nakamura, Yusuke, Park, Jae-Hyun

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Multidisciplinary Care of the Patient with Head and Neck Cancer by Saloura, Vassiliki, MD, Langerman, Alexander, MD, Rudra, Sonali, MD, Chin, Robert, MD, PhD, Cohen, Ezra E.W., MD

“…Head and neck cancer is a heterogeneous group of cancers, which require a multidisciplinary approach to achieve excellent treatment results. This article…”
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Pharmacologic activation of the innate immune system to prevent respiratory viral infections by Cheng, Guanjun, Wang, Liang-Chuan S, Fridlender, Zvi G, Cheng, Guang-Shing, Chen, Bei, Mangalmurti, Nilam S, Saloura, Vassiliki, Yu, Zaifang, Kapoor, Veena, Mozdzanowska, Krystyna, Moon, Edmund, Sun, Jing, Kreindler, James L, Cohen, Noam A, Caton, Andrew J, Erikson, Jan, Albelda, Steven M

“…Drugs that can rapidly inhibit respiratory infection from influenza or other respiratory pathogens are needed. One approach is to engage primary innate immune…”
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