Search Results - "Vassetzky, Y"

requiem to the nuclear matrix: from a controversial concept to 3D organization of the nucleus by Razin, S. V, Iarovaia, O. V, Vassetzky, Y. S

“…The first papers coining the term “nuclear matrix” were published 40 years ago. Here, we review the data obtained during the nuclear matrix studies and discuss…”
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The microRNA-205-5p is correlated to metastatic potential of 21T series: A breast cancer progression model by Stankevicins, L, Barat, A, Dessen, P, Vassetzky, Y, de Moura Gallo, C V

“…MicroRNA is a class of noncoding RNAs able to base pair with complementary messenger RNA sequences, inhibiting their expression. These regulatory molecules…”
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HIV Tat induces a prolonged MYC relocalization next to IGH in circulating B-cells by Germini, D, Tsfasman, T, Klibi, M, El-Amine, R, Pichugin, A, Iarovaia, O V, Bilhou-Nabera, C, Subra, F, Bou Saada, Y, Sukhanova, A, Boutboul, D, Raphaël, M, Wiels, J, Razin, S V, Bury-Moné, S, Oksenhendler, E, Lipinski, M, Vassetzky, Y S

“…With combined antiretroviral therapy (cART), the risk for HIV-infected individuals to develop a non-Hodgkin lymphoma is diminished. However, the incidence of…”
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Mobility of Nuclear Components and Genome Functioning by Arifulin, E. A., Musinova, Y. R., Vassetzky, Y. S., Sheval, E. V.

“…Cell nucleus is characterized by strong compartmentalization of structural components in its three-dimensional space. Certain genomic functions are accompanied…”
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CRISPR/Cas: History and Perspectives by Shmakova, A. A., Shmakova, O. P., Karpukhina, A. A., Vassetzky, Y. S.

“…Discovery of the CRISPR/Cas system revolutionized biology and biomedicine in the 21st century. Here we discuss the milestones in the development of CRISPR/Cas…”
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Antagonistic functional duality of cancer genes by Stepanenko, A.A., Vassetzky, Y.S., Kavsan, V.M.

“…Cancer evolution is a stochastic process both at the genome and gene levels. Most of tumors contain multiple genetic subclones, evolving in either succession…”
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Dual Role of the Extracellular Domain of Human Mucin MUC1 in Metastasis by Syrkina, M.S., Maslakova, A.A., Potashnikova, D.M., Veiko, V.P., Vassetzky, Y.S., Rubtsov, M.A.

“…ABSTRACT Human mucin MUC1 plays an important role in cancer development. The increased level of this molecule expression during cancer cell progression induces…”
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Genetic and Epigenetic Mechanisms of β-Globin Gene Switching by Iarovaia, O. V., Kovina, A. P., Petrova, N. V., Razin, S. V., Ioudinkova, E. S., Vassetzky, Y. S., Ulianov, S. V.

“…Vertebrates have multiple forms of hemoglobin that differ in the composition of their polypeptide chains. During ontogenesis, the composition of these subunits…”
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Exploring the features of Burkitt’s lymphoma-associated t(8;14) translocations generated via a CRISPR/Cas9-based system by Shmakova, A. A., Germini, D., Vassetzky, Y. S.

“…Burkitt lymphoma (BL), an aggressive B-cell lymphoma, is most frequently associated with a chromosomal translocation t(8;14) that relocates the MYC oncogene…”
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Genome- and cell-based strategies in therapy of muscular dystrophies by Bou Saada, Y., Dib, Carla, Lipinski, M., Vassetzky, Y. S.

“…Muscular dystrophies are a group of heterogeneous genetic disorders characterized by progressive loss of skeletal muscle mass. Depending on the muscular…”
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Effect of Environmental Factors on Nuclear Organization and Transformation of Human B Lymphocytes by Sall, F. B., Germini, D., Kovina, A. P., Ribrag, V., Wiels, J., Toure, A. O., Iarovaia, O. V., Lipinski, M., Vassetzky, Y.

“…Chromosomal translocations have long been known for their association with malignant transformation, particularly in hematopoietic disorders such as B-cell…”
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Role of the Nucleolus in Rearrangements of the IGH Locus by Iarovaia, O. V., Ioudinkova, E. S., Razin, S. V., Vassetzky, Y. S.

“…The review summarizes the results from a series of studies focusing on the role that the nucleolus plays in maturation of the IGH locus and the choice of its…”
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HIV 1 Tat induces cell type specific expression of host genes in B cells by Gorbacheva, M., Valyaeva, A., Potashnikova, D., Arifulin, E., Vassetzky, Y., Musinova, Y.

“…In European countries and North America, high rates of Burkitt lymphoma are found preferentially among patients infected with HIV. Interestingly, HIV is mostly…”
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Nuclear organization affects B-cell lymphomagenesis by Germini, D., Bintou Sall, F., Khammad, V., Vassetzky, Y.

“…Recently we discovered a novel mechanism explaining how B-cell lymphomas might be induced during HIV infections. HIV-positive subjects have an increased risk…”
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Nuclear matrix and structural and functional compartmentalization of the eucaryotic cell nucleus by Razin, S. V., Borunova, V. V., Iarovaia, O. V., Vassetzky, Y. S.

“…Becoming popular at the end of the 20th century, the concept of the nuclear matrix implies the existence of a nuclear skeleton that organizes functional…”
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Large-scale chromatin remodelling and transcriptional deregulation on der11 following translocation in Mantle Cell Lymphoma by Germini, D., Bintou Sall, F., Markozashvili, D., Pichugin, A., Camara-Clayette, V., Ribrag, V., Lipinski, M., Vassetzky, Y.

“…Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma characterized by poor prognosis and survival rate. Its genetic hallmark is the…”
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Role of Epstein-Barr Virus Zebra protein in induction of t(8;14) translocation by Sall, F. B., Germini, D., Shmakova, A., Diouf, P. M. D., Wiels, J., Ndour, M., Touré, A. O., Vassetzky, Y.

“…Burkitt lymphoma (BL) is an aggressive Non-Hodgkin Lymphoma characterized by a chromosomal translocation involving the MYC oncogene located on the chromosome 8…”
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Tightly bound to DNA proteins: Possible universal substrates for intranuclear processes by Sjakste, N., Bielskiene, K., Bagdoniene, L., Labeikyte, D., Gutcaits, A., Vassetzky, Y., Sjakste, T.

“…Tightly bound to DNA proteins (TBPs) are a protein group that remains attached to DNA after its deproteinization by phenol, chloroform or salting-out. TBP are…”
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mTORC1 pathway in DNA damage response by Ma, Y., Silveri, L., LaCava, J., Vassetzky, Y., Dokudovskaya, S.

“…Living organisms have evolved various mechanisms to control their metabolism and response to various stresses, allowing them to survive and grow in different…”
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Evolution of α- and β-Globin genes and their regulatory systems in light of the hypothesis of domain organization of the genome by Iarovaia, O. V., Ioudinkova, E. S., Petrova, N. V., Dolgushin, K. V., Kovina, A. V., Nefedochkina, A. V., Vassetzky, Y. S., Razin, S. V.

“…The α- and β-globin gene domains are a traditional model for study of the domain organization of the eucaryotic genome because these genes encode hemoglobin, a…”
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