Search Results - "Vasquez, Paula"
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A biophysical basis for mucus solids concentration as a candidate biomarker for airways disease
Published in PloS one (18-02-2014)“…In human airways diseases, including cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD), host defense is compromised and airways…”
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2
Enrichment of dynamic chromosomal crosslinks drive phase separation of the nucleolus
Published in Nucleic acids research (02-11-2017)“…Regions of highly repetitive DNA, such as those found in the nucleolus, show a self-organization that is marked by spatial segregation and frequent…”
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3
Modeling and Simulation of Mucus Flow in Human Bronchial Epithelial Cell Cultures - Part I: Idealized Axisymmetric Swirling Flow
Published in PLoS computational biology (01-08-2016)“…A multi-mode nonlinear constitutive model for mucus is constructed directly from micro- and macro-rheology experimental data on cell culture mucus, and a…”
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4
Macro–Micro-Coupled Simulations of Dilute Viscoelastic Fluids
Published in Applied sciences (01-11-2023)“…Modeling the flow of polymer solutions requires knowledge at various length and time scales. The macroscopic behavior is described by the overall velocity,…”
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Stable, fertile lines produced by hybridization between allotetraploids Brassica juncea (AABB) and Brassica carinata (BBCC) have merged the A and C genomes
Published in The New phytologist (01-05-2021)“…Summary Many flowering plant taxa contain allopolyploids that share one or more genomes in common. In the Brassica genus, crop species Brassica juncea and…”
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Baseline Goblet Cell Mucin Secretion in the Airways Exceeds Stimulated Secretion over Extended Time Periods, and Is Sensitive to Shear Stress and Intracellular Mucin Stores
Published in PloS one (29-05-2015)“…Airway mucin secretion studies have focused on goblet cell responses to exogenous agonists almost to the exclusion of baseline mucin secretion (BLMS). In human…”
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Erlang-Distributed SEIR Epidemic Models with Cross-Diffusion
Published in Mathematics (Basel) (05-05-2023)“…We explore the effects of cross-diffusion dynamics in epidemiological models. Using reaction–diffusion models of infectious disease, we explicitly consider…”
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The power of weak, transient interactions across biology: A paradigm of emergent behavior
Published in Physica. D (15-11-2023)“…A growing list of diverse biological systems and their equally diverse functionalities provides realizations of a paradigm of emergent behavior. In each of…”
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9
Centromere Tethering Confines Chromosome Domains
Published in Molecular cell (26-12-2013)“…The organization of chromosomes into territories plays an important role in a wide range of cellular processes, including gene expression, transcription, and…”
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10
Entropy gives rise to topologically associating domains
Published in Nucleic acids research (08-07-2016)“…We investigate chromosome organization within the nucleus using polymer models whose formulation is closely guided by experiments in live yeast cells. We…”
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11
Dephosphorylation of the MAP kinases MPK6 and MPK3 fine-tunes responses to wounding and herbivory in Arabidopsis
Published in Plant science (Limerick) (01-02-2024)“…The Arabidopsis MAP Kinases (MAPKs) MPK6 and MPK3 and orthologs in other plants function as major stress signaling hubs. MAPKs are activated by phosphorylation…”
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12
Microtubule dynamics drive enhanced chromatin motion and mobilize telomeres in response to DNA damage
Published in Molecular biology of the cell (15-06-2017)“…Chromatin exhibits increased mobility on DNA damage, but the biophysical basis for this behavior remains unknown. To explore the mechanisms that drive DNA…”
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13
High‐throughput genotyping for species identification and diversity assessment in germplasm collections
Published in Molecular ecology resources (01-09-2015)“…Germplasm collections provide an extremely valuable resource for breeders and researchers. However, misclassification of accessions by species often hinders…”
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14
Model Comparison and Assessment for Single Particle Tracking in Biological Fluids
Published in Journal of the American Statistical Association (01-12-2016)“…State-of-the-art techniques in passive particle-tracking microscopy provide high-resolution path trajectories of diverse foreign particles in biological…”
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15
Understanding Fluid Dynamics from Langevin and Fokker–Planck Equations
Published in Fluids (Basel) (23-03-2020)“…The Langevin equations (LE) and the Fokker–Planck (FP) equations are widely used to describe fluid behavior based on coarse-grained approximations of…”
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16
Polymer models of interphase chromosomes
Published in Nucleus (Austin, Tex.) (01-09-2014)“…Clear organizational patterns on the genome have emerged from the statistics of population studies of fixed cells. However, how these results translate into…”
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A network scission model for wormlike micellar solutions. I. Model formulation and viscometric flow predictions
Published in Journal of non-Newtonian fluid mechanics (20-07-2007)Get full text
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18
DNA loops generate intracentromere tension in mitosis
Published in The Journal of cell biology (17-08-2015)“…The centromere is the DNA locus that dictates kinetochore formation and is visibly apparent as heterochromatin that bridges sister kinetochores in metaphase…”
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Pericentric chromatin loops function as a nonlinear spring in mitotic force balance
Published in The Journal of cell biology (18-03-2013)“…The mechanisms by which sister chromatids maintain biorientation on the metaphase spindle are critical to the fidelity of chromosome segregation. Active force…”
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20
Multi-scale kinetics of a field-directed colloidal phase transition
Published in Proceedings of the National Academy of Sciences - PNAS (02-10-2012)“…Polarizable colloids are expected to form crystalline equilibrium phases when exposed to a steady, uniform field. However, when colloids become localized this…”
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