Search Results - "Vasquez, Guillermo"

Methodological proposal for ecological risk assessment of the coastal zone of Antioquia, Colombia by Yanes, Andrea, Botero, Camilo M., Arrizabalaga, Miriam, Vásquez, Jairo Guillermo

“…•A methodology for conducting risk assessments of coastal areas that focuses on ecosystem health is proposed.•This methodology is the first one applied in a…”
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Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides by Østergaard, Michael E, De Hoyos, Cheryl L, Wan, W Brad, Shen, Wen, Low, Audrey, Berdeja, Andres, Vasquez, Guillermo, Murray, Susan, Migawa, Michael T, Liang, Xue-Hai, Swayze, Eric E, Crooke, Stanley T, Seth, Punit P

“…Therapeutic oligonucleotides are often modified using the phosphorothioate (PS) backbone modification which enhances stability from nuclease mediated…”
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Effect of bow flare on the vertical ship responses in abnormal waves and extreme seas by Rajendran, Suresh, Vásquez, Guillermo, Guedes Soares, C.

“…Linear to fully body nonlinear numerical methods based on strip theory are used to analyze the vertical responses of a bulk carrier, containership and a…”
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Synthesis, antibacterial and antifungal activities of naphthoquinone derivatives: a structure–activity relationship study by Sánchez-Calvo, Juan M., Barbero, Gara R., Guerrero-Vásquez, Guillermo, Durán, Alexandra G., Macías, Mariola, Rodríguez-Iglesias, Manuel A., Molinillo, José M. G., Macías, Francisco A.

“…The synthesis of 1,4-naphthoquinone derivatives is of great interest since these compounds exhibit strong activity as antimalarial, antibacterial, antifungal…”
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Experimental and numerical vertical bending moments of a bulk carrier and a roll-on/roll-off ship in extreme waves by Vásquez, Guillermo, Fonseca, Nuno, Guedes Soares, Carlos

“…This paper investigates the experimental and numerical vertical bending moments induced by abnormal waves on two ships, namely, a bulk carrier and a…”
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Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages by Wan, W Brad, Migawa, Michael T, Vasquez, Guillermo, Murray, Heather M, Nichols, Josh G, Gaus, Hans, Berdeja, Andres, Lee, Sam, Hart, Christopher E, Lima, Walt F, Swayze, Eric E, Seth, Punit P

“…Bicyclic oxazaphospholidine monomers were used to prepare a series of phosphorothioate (PS)-modified gapmer antisense oligonucleotides (ASOs) with control of…”
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Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs by Vasquez, Guillermo, Freestone, Graeme C, Wan, W Brad, Low, Audrey, De Hoyos, Cheryl Li, Yu, Jinghua, Prakash, Thazha P, Ǿstergaard, Michael E, Liang, Xue-hai, Crooke, Stanley T, Swayze, Eric E, Migawa, Michael T, Seth, Punit P

“…Abstract We recently showed that site-specific incorporation of 2′-modifications or neutral linkages in the oligo-deoxynucleotide gap region of toxic…”
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Comprehensive Structure–Activity Relationship of Triantennary N‑Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes by Prakash, Thazha P, Yu, Jinghua, Migawa, Michael T, Kinberger, Garth A, Wan, W. Brad, Østergaard, Michael E, Carty, Recaldo L, Vasquez, Guillermo, Low, Audrey, Chappell, Alfred, Schmidt, Karsten, Aghajan, Mariam, Crosby, Jeff, Murray, Heather M, Booten, Sheri L, Hsiao, Jill, Soriano, Armand, Machemer, Todd, Cauntay, Patrick, Burel, Sebastien A, Murray, Susan F, Gaus, Hans, Graham, Mark J, Swayze, Eric E, Seth, Punit P

“…The comprehensive structure–activity relationships of triantennary GalNAc conjugated ASOs for enhancing potency via ASGR mediated delivery to hepatocytes is…”
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Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides by Østergaard, Michael E, Yu, Jinghua, Kinberger, Garth A, Wan, W. Brad, Migawa, Michael T, Vasquez, Guillermo, Schmidt, Karsten, Gaus, Hans J, Murray, Heather M, Low, Audrey, Swayze, Eric E, Prakash, Thazha P, Seth, Punit P

“…Conjugation of triantennary N-acetyl galactosamine (GalNAc) to oligonucleotide therapeutics results in marked improvement in potency for reducing gene targets…”
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Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes by Kinberger, Garth A., Prakash, Thazha P., Yu, Jinghua, Vasquez, Guillermo, Low, Audrey, Chappell, Alfred, Schmidt, Karsten, Murray, Heather M., Gaus, Hans, Swayze, Eric E., Seth, Punit P.

“…[Display omitted] Antisense oligonucleotides (ASOs) conjugated to trivalent GalNAc ligands show 10-fold enhanced potency for suppressing gene targets expressed…”
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Phytotoxic studies of naphthoquinone intermediates from the synthesis of the natural product Naphthotectone by Chinchilla, Nuria, Guerrero-Vásquez, Guillermo A., Varela, Rosa M., Molinillo, José M. G., Macías, Francisco A.

“…1,4-Naphthoquinones exhibit strong activity as antimalarial, antibacterial, antifungal and anticancer agents. These kinds of compounds have also shown…”
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A convenient synthesis of 5′-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acid by Migawa, Michael T., Prakash, Thazha P., Vasquez, Guillermo, Wan, W. Brad, Yu, Jinghua, Kinberger, Garth A., Østergaard, Michael E., Swayze, Eric E., Seth, Punit P.

“…[Display omitted] A convenient method for the synthesis of several triantennary GalNAc clusters based on a nitromethanetrispropionic acid core was developed…”
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Configuration of the 5′-Methyl Group Modulates the Biophysical and Biological Properties of Locked Nucleic Acid (LNA) Oligonucleotides by Seth, Punit P, Allerson, Charles R, Siwkowski, Andrew, Vasquez, Guillermo, Berdeja, Andres, Migawa, Michael T, Gaus, Hans, Prakash, Thazha P, Bhat, Balkrishen, Swayze, Eric E

“…As part of a program aimed at exploring the structure− activity relationships of 2′,4′-bridged nucleic acid (BNA) containing antisense oligonucleotides (ASOs),…”
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Exploring chemical properties of essential oils from citrus peels using green solvent by Vasquez-Gomez, Katheryn L., Mori-Mestanza, Diner, Caetano, Aline C., Idrogo-Vasquez, Guillermo, Culqui-Arce, Carlos, Auquiñivin-Silva, Erick A., Castro-Alayo, Efraín M., Cruz-Lacerna, Rosita, Perez-Ramos, Harvey A., Balcázar-Zumaeta, César R., Torrejón-Valqui, Llisela, Yoplac-Collantes, Cindy, Yoplac, Ives, Chavez, Segundo G.

“…The research explored the chemical characteristics of essential oils (EOs) extracted from the peels of four citrus fruits grown in northeastern Peru (lime,…”
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Thalidomide for the Treatment of Oral Aphthous Ulcers in Patients with Human Immunodeficiency Virus Infection by Jacobson, Jeffrey M, Greenspan, John S, Spritzler, John, Ketter, Nzeera, Fahey, John L, Jackson, J. Brooks, Fox, Lawrence, Chernoff, Miriam, Wu, Albert W, MacPhail, Laurie A, Vasquez, Guillermo J, Wohl, David A

“…Aphthous ulceration of the mouth, though painful and annoying, is usually a self-limited problem in immunocompetent persons. 1 In patients with human…”
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An Olefin Cross-Metathesis Approach to Depudecin and Stereoisomeric Analogues by Cheng-Sánchez, Iván, García-Ruiz, Cristina, Guerrero-Vásquez, Guillermo A, Sarabia, Francisco

“…A new total synthesis of the natural product (−)-depudecin, a unique and unexplored histone deacetylase (HDAC) inhibitor, is reported. A key feature of the…”
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The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis by Lima, Walt F, Rose, John B, Nichols, Josh G, Wu, Hongjiang, Migawa, Michael T, Wyrzykiewicz, Tadeusz K, Vasquez, Guillermo, Swayze, Eric E, Crooke, Stanley T

“…In a companion study published in this issue (p. 83), we showed that chimeric substrates containing 2'-methoxyethyl (MOE) nucleotides inhibited human RNase H1…”
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Exogenous thyroxine increases GLUT4 translocation to the membrane in cardiomyocytes in insulin resistant OLETF rats Dora A Mendez 1 , Jose G. Soñanez-Organis 2 , Guillermo Vasquez-Anaya 1 , Daisuke Nakano 3 , Akira Nishiyama 3 , Rudy M Ortiz 1 1 Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, CA, USA 2 Division of Science and Engineering, Department of Chemical Biological and Agropecuary Sciences, University of Sonora, Lazaro Cardenas 100, by Mendez, Dora A, Soñanez-Organis, Jose G, Vasquez-Anaya, Guillermo, Nakano, Daisuke, Nishiyama, Akira, Ortiz, Rudy M

“…During insulin resistance the heart undergoes a metabolic shift in which fatty acids (FA) accounts for about 99% of the ATP production. This metabolic shift is…”
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Formation of aromatic compounds precursors during fermentation of Criollo and Forastero cocoa by Castro-Alayo, Efraín M., Idrogo-Vásquez, Guillermo, Siche, Raúl, Cardenas-Toro, Fiorella P.

“…There are three main genetic varieties of cocoa (Theobroma cacao L) used in chocolate making: Forastero, Trinitario and Criollo, which are distinguished by…”
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Metabolomics during the spontaneous fermentation in cocoa (Theobroma cacao L.): An exploraty review by Balcázar-Zumaeta, César R., Castro-Alayo, Efraín M., Cayo-Colca, Ilse S., Idrogo-Vásquez, Guillermo, Muñoz-Astecker, Lucas D.

“…[Display omitted] •Metabolomics uses analytical techniques such as NMR and MS to identify and quantify the fingerprint.•Chemometric tools identify key markers…”
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