Search Results - "Vasquez, Debbie S"

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin by Shackelford, David B., Abt, Evan, Gerken, Laurie, Vasquez, Debbie S., Seki, Atsuko, Leblanc, Mathias, Wei, Liu, Fishbein, Michael C., Czernin, Johannes, Mischel, Paul S., Shaw, Reuben J.

“…The LKB1 (also called STK11) tumor suppressor is mutationally inactivated in ∼20% of non-small cell lung cancers (NSCLC). LKB1 is the major upstream kinase…”
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Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis by Mihaylova, Maria M., Vasquez, Debbie S., Ravnskjaer, Kim, Denechaud, Pierre-Damien, Yu, Ruth T., Alvarez, Jacqueline G., Downes, Michael, Evans, Ronald M., Montminy, Marc, Shaw, Reuben J.

“…Class IIa histone deacetylases (HDACs) are signal-dependent modulators of transcription with established roles in muscle differentiation and neuronal survival…”
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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint by Gwinn, Dana M., Shackelford, David B., Egan, Daniel F., Mihaylova, Maria M., Mery, Annabelle, Vasquez, Debbie S., Turk, Benjamin E., Shaw, Reuben J.

“…AMPK is a highly conserved sensor of cellular energy status that is activated under conditions of low intracellular ATP. AMPK responds to energy stress by…”
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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy by Egan, Daniel F, Shackelford, David B, Mihaylova, Maria M, Gelino, Sara, Kohnz, Rebecca A, Mair, William, Vasquez, Debbie S, Joshi, Aashish, Gwinn, Dana M, Taylor, Rebecca, Asara, John M, Fitzpatrick, James, Dillin, Andrew, Viollet, Benoit, Kundu, Mondira, Hansen, Malene, Shaw, Reuben J

“…Adenosine monophosphate-activated protein kinase (AMPK) is a conserved sensor of intracellular energy activated in response to low nutrient availability and…”
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AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation by Lamia, Katja A, Sachdeva, Uma M, DiTacchio, Luciano, Williams, Elliot C, Alvarez, Jacqueline G, Egan, Daniel F, Vasquez, Debbie S, Juguilon, Henry, Panda, Satchidananda, Shaw, Reuben J, Thompson, Craig B, Evans, Ronald M

“…Circadian clocks coordinate behavioral and physiological processes with daily light-dark cycles by driving rhythmic transcription of thousands of genes…”
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mTOR and HIF-1α-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome by Shackelford, David B, Vasquez, Debbie S, Corbeil, Jacqueline, Wu, Shulin, Leblanc, Mathias, Wu, Chin-Lee, Vera, David R, Shaw, Reuben J

“…Peutz-Jeghers syndrome (PJS) is a familial cancer disorder due to inherited loss of function mutations in the LKB1/ STK11 serine/threonine kinase. PJS patients…”
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mTOR and HIF-1[alpha]-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome by Shackelford, David B, Vasquez, Debbie S, Corbeil, Jacqueline, Wu, Shulin, Leblanc, Mathias, Wu, Chin-Lee, Vera, David R, Shaw, Reuben J

“…Peutz-Jeghers syndrome (PJS) is a familial cancer disorder due to inherited loss of function mutations in the LKB1/ STK11 serine/threonine kinase. PJS patients…”
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mTOR and HIF-1α-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome by Shackelford, David B, Vasquez, Debbie S, Corbeil, Jacqueline, Wu, Shulin, Leblanc, Mathias, Wu, Chin-Lee, Vera, David R, Shaw, Reuben J

“…Peutz-Jeghers syndrome (PJS) is a familial cancer disorder due to inherited loss of function mutations in the LKB1/ STK11 serine/threonine kinase. PJS patients…”
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mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome by Shackelford, David B, Vasquez, Debbie S, Corbeil, Jacqueline, Wu, Shulin, Leblanc, Mathias, Wu, Chin-Lee, Vera, David R, Shaw, Reuben J

“…Peutz-Jeghers syndrome (PJS) is a familial cancer disorder due to inherited loss of function mutations in the LKB1/ STK11 serine/threonine kinase. PJS patients…”
Get full text