Search Results - "Vasilopoulou, Foteini"
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Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I2-Imidazoline Receptor Ligand MCR5
Published in Pharmaceutics (23-05-2020)“…Behavioural and psychological symptoms of dementia (BPSD), including fear-anxiety- and depressive-like behaviour, are present in Alzheimer’s disease (AD),…”
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I2 imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway
Published in GeroScience (01-04-2021)“…Brain aging and dementia are current problems that must be solved. The levels of imidazoline 2 receptors (I 2 -IRs) are increased in the brain in Alzheimer’s…”
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3
Cognitive Decline and BPSD Are Concomitant with Autophagic and Synaptic Deficits Associated with G9a Alterations in Aged SAMP8 Mice
Published in Cells (Basel, Switzerland) (01-08-2022)“…Behavioural and psychological symptoms of dementia (BPSD) are presented in 95% of Alzheimer’s Disease (AD) patients and are also associated with neurotrophin…”
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4
Microglia and TREM2
Published in Neuropharmacology (01-10-2024)“…TREM2 is a membrane receptor solely expressed on microglia in normal brain. In this review we outline recent advances in TREM2 biology and its implications for…”
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Disease‐modifying treatment with I2 imidazoline receptor ligand LSL60101 in an Alzheimer's disease mouse model: a comparative study with donepezil
Published in British journal of pharmacology (01-08-2021)“…Background and Purpose The development of effective therapeutic strategies against Alzheimer's disease (AD) remains a challenge. I2 imidazoline receptor…”
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Disease-modifying treatment with I 2 imidazoline receptor ligand LSL60101 in an Alzheimer's disease mouse model: a comparative study with donepezil
Published in British journal of pharmacology (01-08-2021)“…The development of effective therapeutic strategies against Alzheimer's disease (AD) remains a challenge. I imidazoline receptor ligands have a neuroprotective…”
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11β-HSD1 Inhibition by RL-118 Promotes Autophagy and Correlates with Reduced Oxidative Stress and Inflammation, Enhancing Cognitive Performance in SAMP8 Mouse Model
Published in Molecular neurobiology (01-12-2018)“…Elevated glucocorticoid (GC) exposure is widely accepted as a key factor in the age-related cognitive decline in rodents and humans. 11β-HSD1 is a key enzyme…”
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Microarray Analysis Revealed Inflammatory Transcriptomic Changes after LSL60101 Treatment in 5XFAD Mice Model
Published in Genes (26-08-2021)“…I2-IR have been found dysregulated in patients with neurodegenerative diseases, such as Alzheimer's disease (AD), in which the importance of neuroinflammation…”
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Benzofuranyl-2-imidazoles as imidazoline I2 receptor ligands for Alzheimer's disease
Published in European journal of medicinal chemistry (15-10-2021)“…Recent findings unveil the pharmacological modulation of imidazoline I2 receptors (I2-IR) as a novel strategy to face unmet medical neurodegenerative diseases…”
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Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice
Published in Neurotherapeutics (01-04-2019)“…As populations increase their life expectancy, age-related neurodegenerative disorders such as Alzheimer’s disease have become more common. I 2 -Imidazoline…”
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Behavioral and Cognitive Improvement Induced by Novel Imidazoline I 2 Receptor Ligands in Female SAMP8 Mice
Published in Neurotherapeutics (01-04-2019)“…As populations increase their life expectancy, age-related neurodegenerative disorders such as Alzheimer's disease have become more common. I -Imidazoline…”
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12
Bicyclic α‑Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer’s Disease
Published in Journal of medicinal chemistry (09-04-2020)“…Imidazoline I2 receptors (I2-IR), widely distributed in the CNS and altered in patients that suffer from neurodegenerative disorders, are orphans from a…”
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13
Correction to Bicyclic α-Iminophosphonates as High Affinity Imidazoline I 2 Receptor Ligands for Alzheimer’s Disease
Published in Journal of medicinal chemistry (24-09-2020)Get full text
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14
Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I 2 -Imidazoline Receptor Ligand MCR5
Published in Pharmaceutics (23-05-2020)“…Behavioural and psychological symptoms of dementia (BPSD), including fear-anxiety- and depressive-like behaviour, are present in Alzheimer's disease (AD),…”
Get full text
Journal Article -
15
I 2 imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway
Published in GeroScience (01-04-2021)“…Brain aging and dementia are current problems that must be solved. The levels of imidazoline 2 receptors (I -IRs) are increased in the brain in Alzheimer's…”
Get full text
Journal Article -
16
Bicyclic α-Iminophosphonates as High Affinity Imidazoline I 2 Receptor Ligands for Alzheimer's Disease
Published in Journal of medicinal chemistry (09-04-2020)“…Imidazoline I receptors (I -IR), widely distributed in the CNS and altered in patients that suffer from neurodegenerative disorders, are orphans from a…”
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Journal Article -
17
Correction to Bicyclic α‑Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer’s Disease
Published in Journal of medicinal chemistry (24-09-2020)Get full text
Journal Article