Search Results - "Vasilogianni, Areti‐Maria"

Quantitative Proteomics of Hepatic Drug‐Metabolizing Enzymes and Transporters in Patients With Colorectal Cancer Metastasis by Vasilogianni, Areti‐Maria, Al‐Majdoub, Zubida M., Achour, Brahim, Annie Peters, Sheila, Barber, Jill, Rostami‐Hodjegan, Amin

“…The impact of liver cancer metastasis on protein abundance of 22 drug‐metabolizing enzymes (DMEs) and 25 transporters was investigated using liquid…”
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Proteomics of colorectal cancer liver metastasis: A quantitative focus on drug elimination and pharmacodynamics effects by Vasilogianni, Areti‐Maria, Al‐Majdoub, Zubida M., Achour, Brahim, Peters, Sheila Annie, Rostami‐Hodjegan, Amin, Barber, Jill

“…Aims This study aims to quantify drug‐metabolising enzymes, transporters, receptor tyrosine kinases (RTKs) and protein markers (involved in pathways affected…”
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Mass spectrometry‐based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin by Al‐Majdoub, Zubida M., Achour, Brahim, Couto, Narciso, Howard, Martyn, Elmorsi, Yasmine, Scotcher, Daniel, Alrubia, Sarah, El‐Khateeb, Eman, Vasilogianni, Areti‐Maria, Alohali, Noura, Neuhoff, Sibylle, Schmitt, Lutz, Rostami‐Hodjegan, Amin, Barber, Jill

“…ABC transporters (ATP‐binding cassette transporter) traffic drugs and their metabolites across membranes, making ABC transporter expression levels a key factor…”
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Proteomic quantification of receptor tyrosine kinases involved in the development and progression of colorectal cancer liver metastasis by Vasilogianni, Areti-Maria, Al-Majdoub, Zubida M, Achour, Brahim, Peters, Sheila Annie, Rostami-Hodjegan, Amin, Barber, Jill

“…Alterations in expression and activity of human receptor tyrosine kinases (RTKs) are associated with cancer progression and in response to therapeutic…”
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Hepatic Scaling Factors for In Vitro-In Vivo Extrapolation of Metabolic Drug Clearance in Patients with Colorectal Cancer with Liver Metastasis by Vasilogianni, Areti-Maria, Achour, Brahim, Scotcher, Daniel, Peters, Sheila Annie, Al-Majdoub, Zubida M, Barber, Jill, Rostami-Hodjegan, Amin

“…In vitro-in vivo extrapolation (IVIVE) linked with physiologically based pharmacokinetics (PBPK) modeling is used to predict the fates of drugs in patients…”
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Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters by Barber, Jill, Al-Majdoub, Zubida M, Couto, Narciso, Vasilogianni, Areti-Maria, Tillmann, Annika, Alrubia, Sarah, Rostami-Hodjegan, Amin, Achour, Brahim

“…Building and refining pharmacology models require "system" data derived from tissues and in vitro systems analyzed by quantitative proteomics. Label-free…”
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Proteomic quantification of perturbation to pharmacokinetic target proteins in liver disease by Vasilogianni, Areti-Maria, El-Khateeb, Eman, Al-Majdoub, Zubida M., Alrubia, Sarah, Rostami-Hodjegan, Amin, Barber, Jill, Achour, Brahim

“…Model-based assessment of drug pharmacokinetics in liver disease requires quantification of abundance and disease-related changes in hepatic enzymes and…”
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Quantitative mass spectrometry-based proteomics in the era of model-informed drug development: Applications in translational pharmacology and recommendations for best practice by El-Khateeb, Eman, Vasilogianni, Areti-Maria, Alrubia, Sarah, Al-Majdoub, Zubida M., Couto, Narciso, Howard, Martyn, Barber, Jill, Rostami-Hodjegan, Amin, Achour, Brahim

“…Quantitative translation of the fate and action of a drug in the body is facilitated by models that allow extrapolation of in vitro measurements (such as the…”
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Toxicity assessment and comparison of the land snail's Cornu aspersum responses against CuO nanoparticles and ZnO nanoparticles by Feidantsis, Konstantinos, Kalogiannis, Stavros, Marinoni, Angela, Vasilogianni, Areti-Maria, Gkanatsiou, Christina, Kastrinaki, Georgia, Dendrinou-Samara, Catherine, Kaloyianni, Martha

“…The goal of the present study was to examine the effects of ZnO NPs and CuO NPs on Cornu aspersum land snail, enlightening their cytotoxic profile. ZnO NPs and…”
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A family of QconCATs (Quantification conCATemers) for the quantification of human pharmacological target proteins by Vasilogianni, Areti-Maria, El-Khateeb, Eman, Achour, Brahim, Alrubia, Sarah, Rostami-Hodjegan, Amin, Barber, Jill, Al-Majdoub, Zubida M.

“…We have developed a family of QconCAT standards for the absolute quantification of pharmacological target proteins in a variety of human tissues. The QconCATs…”
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Impact of Gastrointestinal (Gi) and Hepatic Cancer on Enzyme and Transporter Abundance Contributing to Variability in Drug Exposure by Vasilogianni, Areti Maria

“…Clinical trials in oncology recruit heterogeneous participants not often representative of the target cohort, leading to large variability in pharmacokinetics…”
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