Microbiome Responses to an Uncontrolled Short-Term Diet Intervention in the Frame of the Citizen Science Project

Microbiome Responses to an Uncontrolled Short-Term Diet Intervention in the Frame of the Citizen Science Project

Personalized nutrition is of increasing interest to individuals actively monitoring their health. The relations between the duration of diet intervention and the effects on gut microbiota have yet to be elucidated. Here we examined the associations of short-term dietary changes, long-term dietary ha...

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Published in:Nutrients Vol. 10; no. 5; p. 576
Main Authors: Klimenko, Natalia S, Tyakht, Alexander V, Popenko, Anna S, Vasiliev, Anatoly S, Altukhov, Ilya A, Ischenko, Dmitry S, Shashkova, Tatiana I, Efimova, Daria A, Nikogosov, Dmitri A, Osipenko, Dmitrii A, Musienko, Sergey V, Selezneva, Kseniya S, Baranova, Ancha, Kurilshikov, Alexander M, Toshchakov, Stepan M, Korzhenkov, Aleksei A, Samarov, Nazar I, Shevchenko, Margarita A, Tepliuk, Alina V, Alexeev, Dmitry G
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 08-05-2018
MDPI
Subjects:
16S rRNA metagenomics
citizen science
Communities
Community structure
Diet
gut microbiota
Intervention
Intestinal microflora
microbiome stability
Microbiomes
Microbiota
Nutrition
personalized diet
responders
rRNA 16S
microbiome stability
16S rRNA metagenomics
citizen science
intervention
personalized diet
responders
gut microbiota
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Summary:Personalized nutrition is of increasing interest to individuals actively monitoring their health. The relations between the duration of diet intervention and the effects on gut microbiota have yet to be elucidated. Here we examined the associations of short-term dietary changes, long-term dietary habits and lifestyle with gut microbiota. Stool samples from 248 citizen-science volunteers were collected before and after a self-reported 2-week personalized diet intervention, then analyzed using 16S rRNA sequencing. Considerable correlations between long-term dietary habits and gut community structure were detected. A higher intake of vegetables and fruits was associated with increased levels of butyrate-producing and higher community richness. A paired comparison of the metagenomes before and after the 2-week intervention showed that even a brief, uncontrolled intervention produced profound changes in community structure: resulting in decreased levels of , and families and decreased alpha-diversity coupled with an increase of , , and butyrate-producing - as well as the prevalence of a permatype (a bootstrapping-based variation of enterotype) associated with a higher diversity of diet. The response of microbiota to the intervention was dependent on the initial microbiota state. These findings pave the way for the development of an individualized diet.
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ISSN:2072-6643
2072-6643
DOI:10.3390/nu10050576