Search Results - "Vasilevich, Natalya"

Biological evaluation of 9-thioansamitocin P3 by Vasilevich, Natalya I., Jiang, Huangyu, Xiao, Haihua, Feng, Kunxian, Jian, Chengfang, Chen, Changfeng, Li, Min, Chen, Zhenhua, Pang, Li, Li, Xiang, Chestkov, Alexander V., Sun, Andre H., Xu, Wang, Fuselier, Joseph A., Coy, David H., Sun, Lichun

“…Highly cytotoxic maytansine derivatives are widely used in targeted tumor delivery. Structure-activity studies published earlier suggested the C9 carbinol to…”
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Lessons from Natural Products Chemistry Can Offer Novel Approaches for Synthetic Chemistry in Drug Discovery: Miniperspective by Vasilevich, Natalya I, Kombarov, Roman V, Genis, Dmitry V, Kirpichenok, Michael A

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Search for Potent and Selective Aurora A Inhibitors Based on General Ser/Thr Kinase Pharmacophore Model by Vasilevich, Natalya I, Tatarskiy, Victor V, Aksenova, Elena A, Kazyulkin, Denis N, Afanasyev, Ilya I

“…Based on the data for compounds known from the literature to be active against various types of Ser/Thr kinases, a general pharmachophore model for these types…”
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General Ser/Thr Kinases Pharmacophore Approach for Selective Kinase Inhibitors Search as Exemplified by Design of Potent and Selective Aurora A Inhibitors by Vasilevich, Natalya I., Aksenova, Elena A., Kazyulkin, Denis N., Afanasyev, Ilya I.

“…A general pharmachophore model for various types of Ser/Thr kinases was developed. Search for the molecules fitting to this pharmacophore among ASINEX…”
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Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O, Parkhill, Eric Q, Vasilevich, Natalya I, Glushkov, Andrei I, Zilbershtein, Timur M, Ivanov, Alexei V, Cole, Andrew G, Henderson, Ian, Zautke, Nathan A, Brunn, Sandra A, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W, Zablocki, Jeff

“…We identified a series of structurally novel SCD (Delta9 desaturase) inhibitors via high-throughput screening and follow-up SAR studies. Modification of the…”
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A Re-examination of the MDM2/p53 Interaction Leads to Revised Design Criteria for Novel Inhibitors by Vasilevich, Natalya I., Afanasyev, Ilya I., Kovalskiy, Dmitry A., Genis, Dmitry V., Kochubey, Valery S.

“…The general model of epitope‐type MDM2 inhibitor was developed based on the structural information on the complexes between MDM2 and various low molecular…”
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Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O., Zilbershtein, Timur M., Migulin, Vasily A., Vasilevich, Natalya I., Parkhill, Eric Q., Glushkov, Andrei I., McGregor, Malcolm J., Brunn, Sandra A., Chu, Nancy, Hao, Jia, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W., Zablocki, Jeff

“…Two structurally distinct series of SCD (Δ9 desaturase) inhibitors (1 and 2) have been previously reported by our group. In the present work, we merged the…”
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Determination of flomoxef in human plasma by liquid chromatography/electrospray ionization tandem mass spectrometry by Kravtsova, Oxana Yu, Paramonov, Sergey A., Vasilevich, Natalya I., Kazyulkin, Denis N., Vlasova, Ekaterina, Engsig, Michael

“…ABSTRACT A specific, sensitive, rapid and reproducible method for the determination of flomoxef in human plasma using high‐performance liquid…”
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Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design by SUN, Lichun, VASILEVICH, Natalya I, FUSELIER, Joseph A, HOCART, Simon J, COY, David H

“…A series of novel 1,4-diaryl-2-azetidinones was prepared by stereospecific Staudinger reaction as conformationally restricted analogues of combretastatin A-4…”
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Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA β-lactams by Pohlmann, Jens, Vasilevich, Natalya I., Glushkov, Andrei I., Kellenberger, Laurenz, Shapiro, Stuart, Caspers, Patrick, Page, Malcolm G.P., Danel, Franck

“…Novel C(3) propenylamide and propenylsulfonamide cephalosporins have been synthesized and tested for their ability to inhibit the penicillin-binding protein 2′…”
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Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions by Babaev, Eugene V, Vasilevich, Natalya I, Ivushkina, Anna S

“…2-Aryl-6-cyano-7-methyl-5-indolizinones were successfully converted into 2-aryl-5-chloro-6-cyano-7-methylindolizines. The obtained 5-chloroindolizines readily…”
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Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O., Vasilevich, Natalya I., Parkhill, Eric Q., Glushkov, Andrei I., Zilbershtein, Timur M., Mayboroda, Elena I., Boze, Melanie A., Cole, Andrew G., Henderson, Ian, Zautke, Nathan A., Brunn, Sandra A., Chu, Nancy, Hao, Jia, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W., Zablocki, Jeff

“…We discovered a structurally novel SCD inhibitor CVT-11,563 (IC50 119nM, HEPG2 assay), selective against Δ5 and Δ6 desaturases, with excellent PK parameters…”
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Abilities of 3,4-Diarylfuran-2-one Analogs of Combretastatin A-4 to Inhibit Both Proliferation of Tumor Cell Lines and Growth of Relevant Tumors in Nude Mice by LICHUN SUN, VASILEVICH, Natalya I, FUSELIER, Joseph A, COY, David H

“…Background: Combretastatin A-4 (CA-4) and its analogs are potent inhibitors of tubulin polymerization and display strong inhibitory activity on both solid…”
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Abstract 4957: The targeting drug conjugate Tye1001 displayed its potent anti-tumor efficacy in lymphoma by Sun, Lichun, Yang, Mengli, Xiao, Haihua, Tian, Yuan, Vasilevich, Natalya, Fuselier, Joseph, Coy, David

“…Multiple drug-targeting strategies have been applied to drug development in order to reduce the toxic side effects of the traditional chemotherapy while…”
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Abstract 5345: The application of CDK16 inhibitors in the treatment of triple-negative breast cancer by Xiao, Haihua, Jiang, Huangyu, Feng, Kunxian, Yang, Mengli, Yang, Jinping, Jian, Chengfang, Tian, Yuan, Vasilevich, Natalya, Sun, Lichun

“…Triple-negative breast cancer (TNBC) with estrogen receptor (ER), progesterone receptor (PR) and HER2 (c-erbB-2, neu) being negatively expressed in patient…”
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Oxygen-containing fragments in natural products by Titarenko, Zoya, Vasilevich, Natalya, Zernov, Vladimir, Kirpichenok, Michael, Genis, Dmitry

“…An analysis of the chemical environment of the oxygen atoms in the DNP database compared to the CMC and SCD databases was performed. Some structural clusters…”
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Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA b-lactams by Pohlmann, Jens, Vasilevich, Natalya I, Glushkov, Andrei I, Kellenberger, Laurenz, Shapiro, Stuart, Caspers, Patrick, Page, Malcolm GP, Danel, Franck

“…Novel C(3) propenylamide and propenylsulfonamide cephalosporins have been synthesized and tested for their ability to inhibit the penicillin-binding protein 2'…”
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Lessons from natural products chemistry can offer novel approaches for synthetic chemistry in drug discovery by Vasilevich, Natalya I, Kombarov, Roman V, Genis, Dmitry V, Kirpichenok, Michael A

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An adjustable release rate linking strategy for cytotoxin–Peptide conjugates by Fuselier, Joseph A., Sun, Lichun, Woltering, S.Nathaniel, Murphy, William A., Vasilevich, Natalya, Coy, David H.

“…Peptide hormones are often rapidly internalized after binding to and activation of their receptors which are sometimes over-expressed on tumor cells. Thus,…”
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Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA β-lactams by POHLMANN, Jens, VASILEVICH, Natalya I, GLUSHKOV, Andrei I, KELLENBERGER, Laurenz, SHAPIRO, Stuart, CASPERS, Patrick, PAGE, Malcolm G. P, DANEL, Franck

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