Search Results - "Vasdev, Neil"

Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO by Narayanaswami, Vidya, Dahl, Kenneth, Bernard-Gauthier, Vadim, Josephson, Lee, Cumming, Paul, Vasdev, Neil

“…The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and…”
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Tau positron emission tomographic imaging in aging and early Alzheimer disease by Johnson, Keith A., Schultz, Aaron, Betensky, Rebecca A., Becker, J. Alex, Sepulcre, Jorge, Rentz, Dorene, Mormino, Elizabeth, Chhatwal, Jasmeer, Amariglio, Rebecca, Papp, Kate, Marshall, Gad, Albers, Mark, Mauro, Samantha, Pepin, Lesley, Alverio, Jonathan, Judge, Kelly, Philiossaint, Marlie, Shoup, Timothy, Yokell, Daniel, Dickerson, Bradford, Gomez-Isla, Teresa, Hyman, Bradley, Vasdev, Neil, Sperling, Reisa

“…Objective Detection of focal brain tau deposition during life could greatly facilitate accurate diagnosis of Alzheimer disease (AD), staging and monitoring of…”
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Sifting through the surfeit of neuroinflammation tracers by Cumming, Paul, Burgher, Bjorn, Patkar, Omkar, Breakspear, Michael, Vasdev, Neil, Thomas, Paul, Liu, Guo-Jun, Banati, Richard

“…The first phase of molecular brain imaging of microglial activation in neuroinflammatory conditions began some 20 years ago with the introduction of…”
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Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases by Gomperts, Stephen N, Locascio, Joseph J, Makaretz, Sara J, Schultz, Aaron, Caso, Christina, Vasdev, Neil, Sperling, Reisa, Growdon, John H, Dickerson, Bradford C, Johnson, Keith

“…The causes of cognitive impairment in dementia with Lewy bodies (DLB) and Parkinson disease (PD) are multifactorial. Tau pathologic changes are commonly…”
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Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue by Marquié, Marta, Normandin, Marc D., Vanderburg, Charles R., Costantino, Isabel M., Bien, Elizabeth A., Rycyna, Lisa G., Klunk, William E., Mathis, Chester A., Ikonomovic, Milos D., Debnath, Manik L., Vasdev, Neil, Dickerson, Bradford C., Gomperts, Stephen N., Growdon, John H., Johnson, Keith A., Frosch, Matthew P., Hyman, Bradley T., Gómez-Isla, Teresa

“…Objective To examine region‐ and substrate‐specific autoradiographic and in vitro binding patterns of positron emission tomography tracer [F‐18]‐AV‐1451…”
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Recent Developments in Carbon-11 Chemistry and Applications for First-In-Human PET Studies by Pees, Anna, Chassé, Melissa, Lindberg, Anton, Vasdev, Neil

“…Positron emission tomography (PET) is a molecular imaging technique that makes use of radiolabelled molecules for in vivo evaluation. Carbon-11 is a frequently…”
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Flortaucipir tau PET imaging in semantic variant primary progressive aphasia by Makaretz, Sara J, Quimby, Megan, Collins, Jessica, Makris, Nikos, McGinnis, Scott, Schultz, Aaron, Vasdev, Neil, Johnson, Keith A, Dickerson, Bradford C

“…ObjectiveThe semantic variant of primary progressive aphasia (svPPA) is typically associated with frontotemporal lobar degeneration (FTLD) with longTAR…”
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Emerging targets for positron emission tomography imaging in proteinopathies by Melissa Chassé, Neil Vasdev

“…Abstract Positron emission tomography (PET) imaging of neurodegenerative disease has historically focused on a small number of established targets. The…”
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Radiosynthesis of a Bruton's tyrosine kinase inhibitor, [11C]Tolebrutinib, via palladium‐NiXantphos‐mediated carbonylation by Dahl, Kenneth, Turner, Timothy, Vasdev, Neil

“…Bruton's tyrosine kinase (BTK) is a key component in the B‐cell receptor signaling pathway and is consequently a target for in vivo imaging of B‐cell…”
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Recent developments on PET radiotracers for TSPO and their applications in neuroimaging by Zhang, Lingling, Hu, Kuan, Shao, Tuo, Hou, Lu, Zhang, Shaojuan, Ye, Weijian, Josephson, Lee, Meyer, Jeffrey H., Zhang, Ming-Rong, Vasdev, Neil, Wang, Jinghao, Xu, Hao, Wang, Lu, Liang, Steven H.

“…The 18 kDa translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor, is predominately localized to the outer mitochondrial…”
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PET Imaging of Fructose Metabolism in a Rodent Model of Neuroinflammation with 6-[ 18 F]fluoro-6-deoxy-D-fructose by Boyle, Amanda J, Murrell, Emily, Tong, Junchao, Schifani, Christin, Narvaez, Andrea, Wuest, Melinda, West, Frederick, Wuest, Frank, Vasdev, Neil

“…Fluorine-18 labeled 6-fluoro-6-deoxy-D-fructose (6-[ F]FDF) targets the fructose-preferred facilitative hexose transporter GLUT5, which is expressed…”
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Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development by Hou, Lu, Rong, Jian, Haider, Ahmed, Ogasawara, Daisuke, Varlow, Cassis, Schafroth, Michael A, Mu, Linjing, Gan, Jiefeng, Xu, Hao, Fowler, Christopher J, Zhang, Ming-Rong, Vasdev, Neil, Ametamey, Simon, Cravatt, Benjamin F, Wang, Lu, Liang, Steven H

“…The endocannabinoid system (ECS) is involved in a wide range of biological functions and comprises cannabinoid receptors and enzymes responsible for…”
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Head-to-Head Comparison of Tau-PET Radioligands for Imaging TDP-43 in Post-Mortem ALS Brain by Knight, Ashley C., Morrone, Christopher D., Varlow, Cassis, Yu, Wai Haung, McQuade, Paul, Vasdev, Neil

“…Purpose In vivo detection of transactivation response element DNA binding protein-43 kDa (TDP-43) aggregates through positron emission tomography (PET) would…”
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Improving PET Imaging Acquisition and Analysis With Machine Learning: A Narrative Review With Focus on Alzheimer's Disease and Oncology by Duffy, Ian R., Boyle, Amanda J., Vasdev, Neil

“…Machine learning (ML) algorithms have found increasing utility in the medical imaging field and numerous applications in the analysis of digital biomarkers…”
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Reactive Palladium–Ligand Complexes for 11C-Carbonylation at Ambient Pressure: A Breakthrough in Carbon-11 Chemistry by Dahl, Kenneth, Lindberg, Anton, Vasdev, Neil, Schou, Magnus

“…The Pd–Xantphos-mediated 11C-carbonylation protocol (also known as the “Xantphos- method”), due to its simplistic and convenient nature, has facilitated…”
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A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation by Wang, Lu, Cheng, Ran, Fujinaga, Masayuki, Yang, Jian, Zhang, Yiding, Hatori, Akiko, Kumata, Katsushi, Yang, Jing, Vasdev, Neil, Du, Yunfei, Ran, Chongzhao, Zhang, Ming-Rong, Liang, Steven H

“…A suitable TSPO PET ligand may visualize and quantify neuroinflammation in a living brain. Herein we report a 18F-ligand, [ 18 F]­2 ([18F]­FDPA), is…”
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Preliminary Assessment of Reference Region Quantification and Reduced Scanning Times for [18F]SynVesT-1 PET in Parkinson’s Disease by Smart, Kelly, Uribe, Carme, Desmond, Kimberly L., Martin, Sarah L., Vasdev, Neil, Strafella, Antonio P.

“…Synaptic density in the central nervous system can be measured in vivo using PET with [18F]SynVesT-1. While [18F]SynVesT-1 has been proven to be a powerful…”
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Selected PET Radioligands for Ion Channel Linked Neuroreceptor Imaging: Focus on GABA, NMDA and nACh Receptors by Kassenbrock, Alina, Vasdev, Neil, Liang, Steven H

“…Positron emission tomography (PET) neuroimaging of ion channel linked receptors is a developing area of preclinical and clinical research. The present review…”
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Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics by Rotstein, Benjamin H., Stephenson, Nickeisha A., Vasdev, Neil, Liang, Steven H.

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Editorial: Positron Emission Tomography (PET) Imaging of Brain Biochemistry: Beyond High-Affinity Radioligands by Kilbourn, Michael R, Scott, Peter J H, Vasdev, Neil

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