Search Results - "Varzavand, Afshin"

α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway by Varzavand, Afshin, Hacker, Will, Ma, Deqin, Gibson-Corley, Katherine, Hawayek, Maria, Tayh, Omar J, Brown, James A, Henry, Michael D, Stipp, Christopher S

“…Existing anticancer strategies focused on disrupting integrin functions in tumor cells or tumor-involved endothelial cells have met limited success. An…”
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A Critical Role for Tetraspanin CD151 in α3β1 and α6β4 Integrin–dependent Tumor Cell Functions on Laminin-5 by Winterwood, Nicole E., Varzavand, Afshin, Meland, Marit N., Ashman, Leonie K., Stipp, Christopher S.

“…The basement membrane protein laminin-5 supports tumor cell adhesion and motility and is implicated at multiple steps of the metastatic cascade. Tetraspanin…”
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Abl kinases can function as suppressors of tumor progression and metastasis by Marchal, Melissa A., Moose, Devon L., Varzavand, Afshin, Jordan, Nicole E., Taylor, Destiney, Tanas, Munir R., Brown, James A., Henry, Michael D., Stipp, Christopher S.

“…Introduction Abl family kinases function as proto-oncogenes in various leukemias, and pro-tumor functions have been discovered for Abl kinases in many solid…”
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Functional Genomic Screening Independently Identifies CUL3 as a Mediator of Vemurafenib Resistance via Src-Rac1 Signaling Axis by Vanneste, Marion, Feddersen, Charlotte R, Varzavand, Afshin, Zhu, Elliot Y, Foley, Tyler, Zhao, Lei, Holt, Kathleen H, Milhem, Mohammed, Piper, Robert, Stipp, Christopher S, Dupuy, Adam J, Henry, Michael D

“…Patients with malignant melanoma have a 5-year survival rate of only 15-20% once the tumor has metastasized to distant tissues. While MAP kinase pathway…”
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Diagnostic challenge: Juvenile bullous pemphigoid with a negative BP180 ELISA by Fairley, Janet A, Berrebi, Kristen G, Poggemiller, Andrew M, Varzavand, Afshin, Messingham, Kelly N

“…Bullous pemphigoid (BP) is an autoimmune blistering disease primarily affecting the elderly, whereas cases of juvenile BP are rare. Both types of BP are…”
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Abstract B01: Genome-scale shRNA screen provides insight into the role of CUL3 in adaptive mechanisms of resistance to mutant BRAF inhibition by Vanneste, Marion, Zhu, Eliot, Feddersen, Charlotte, Varzavand, Afshin, Foley, Tyler, Zhao, Lei, Piper, Rob, Stipp, Christopher, Dupuy, Adam, Henry, Michael

“…Abstract MAPK inhibition with targeted BRAF inhibitors has revolutionized the treatment of BRAF-mutant melanoma. However, in most cases, the effects of mutant…”
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Elevated levels of sCD48 are inversely correlated with markers of disease activity in bullous pemphigoid by Treco, Emma, Huan, Eunice, Varzavand, Afshin, Fairley, Janet A., Messingham, Kelly N.

“…sCD48 is elevated in diseases characterized by IgE and eosinophilia. Thus, serum levels sCD48 were evaluated in relation to clinical characteristics of Bullous…”
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Abstract PR17: Sleeping Beauty mutagenesis reveals a Src-dependent DBL GEF family signaling mechanism driving MAPK inhibitor resistance in BRAF mutant melanoma by Feddersen, Charlotte R., Schillo, Jacob, Varzavand, Afshin, Vaughn, Hayley, Voight, Andrew, Zhu, Eliot, Riordan, Jesse D, Stipp, Christopher S., Dupuy, Adam J.

“…Abstract BRAF/MEK inhibition remains an important treatment option for patients with BRAF V600 mutant melanoma who show disease progression on immunotherapy;…”
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Abstract B08: Identification and characterization of Rho family GTPases as drivers of drug resistance in BRAFV600 mutant melanoma by Schillo, Jacob L., Feddersen, Charlotte R., Varzavand, Afshin, Vaughn, Hayley R., Wadsworth, Lexy S., Voigt, Andrew P., Zhu, Eliot Y., Riordan, Jesse D., Stipp, Christopher S., Dupuy, Adam J.

“…Abstract The serine/threonine protein kinase BRAF is mutated in approximately 50% of cutaneous melanomas, leading to hyperactivation of the MAPK/ERK pathway…”
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Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma by Feddersen, Charlotte R, Schillo, Jacob L, Varzavand, Afshin, Vaughn, Hayley R, Wadsworth, Lexy S, Voigt, Andrew P, Zhu, Eliot Y, Jennings, Brooke M, Mullen, Sarah A, Bobera, Jeremy, Riordan, Jesse D, Stipp, Christopher S, Dupuy, Adam J

“…The use of selective BRAF inhibitors (BRAFi) has produced remarkable outcomes for patients with advanced cutaneous melanoma harboring a mutation…”
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MP99-10 SYNERGISTIC CONTRIBUTIONS OF ABL1 AND ABL2 TO AN ?3?1 INTEGRIN – ABL KINASE – HIPPO SUPPRESSOR PATHWAY IN PROSTATE CANCER by Varzavand, Afshin, Hacker, William, Ma, Deqin, Gibson-Corley, Katherin, Hawayek, Maria, Brown, James, Henry, Michael, Stipp, Christopher

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Single-cell genomics analysis reveals complex genetic interactions in an in vivo model of acquired BRAF inhibitor resistance by Schillo, Jacob L, Feddersen, Charlotte R, Peplinski, Rebekah M, Powell, Lexy S, Varzavand, Afshin, Stipp, Christopher S, Riordan, Jesse D, Dupuy, Adam J

“…The evolution of therapeutic resistance is a major obstacle to the success of targeted oncology drugs. While both inter- and intratumoral heterogeneity limit…”
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Integrin α3β1 regulates tumor cell responses to stromal cells and can function to suppress prostate cancer metastatic colonization by Varzavand, Afshin, Drake, Justin M., Svensson, Robert U., Herndon, Mary E., Zhou, Bo, Henry, Michael D., Stipp, Christopher S.

“…Integrin α3β1 promotes tumor cell adhesion, migration, and invasion on laminin isoforms, and several clinical studies have indicated a correlation between…”
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Integrin [alpha]3[beta]1 regulates tumor cell responses to stromal cells and can function to suppress prostate cancer metastatic colonization by Varzavand, Afshin, Drake, Justin M, Svensson, Robert U, Herndon, Mary E, Zhou, Bo, Henry, Michael D, Stipp, Christopher S

“…Integrin [alpha]3[beta]1 promotes tumor cell adhesion, migration, and invasion on laminin isoforms, and several clinical studies have indicated a correlation…”
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Integrin α3β1 regulates tumor cell responses to stromal cells and can function to suppress prostate cancer metastatic colonization by Varzavand, Afshin, Drake, Justin M., Svensson, Robert U., Herndon, Mary E., Zhou, Bo, Henry, Michael D., Stipp, Christopher S.

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A Critical Role for Tetraspanin CD151 in alpha 3 beta 1 and alpha 6 beta 4 Integrin- dependent Tumor Cell Functions on Laminin-5 by Winterwood, Nicole E, Varzavand, Afshin, Meland, Marit N, Ashman, Leonie K, Stipp, Christopher S

“…The basement membrane protein laminin-5 supports tumor cell adhesion and motility and is implicated at multiple steps of the metastatic cascade. Tetraspanin…”
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A critical role for tetraspanin CD151 in alpha3beta1 and alpha6beta4 integrin-dependent tumor cell functions on laminin-5 by Winterwood, Nicole E, Varzavand, Afshin, Meland, Marit N, Ashman, Leonie K, Stipp, Christopher S

“…The basement membrane protein laminin-5 supports tumor cell adhesion and motility and is implicated at multiple steps of the metastatic cascade. Tetraspanin…”
Get full text