Search Results - "Vary, Calvin P."

Interactions with Muscle Cells Boost Fusion, Stemness, and Drug Resistance of Prostate Cancer Cells by Uygur, Berna, Leikina, Evgenia, Melikov, Kamran, Villasmil, Rafael, Verma, Santosh K, Vary, Calvin P H, Chernomordik, Leonid V

“…Poorly understood interactions with nonmalignant cells within the tumor microenvironment play an important role in cancer progression. Here, we explored…”
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BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses by Young, Kira, Tweedie, Eric, Conley, Barbara, Ames, Jacquelyn, FitzSimons, MaryLynn, Brooks, Peter, Liaw, Lucy, Vary, Calvin P H

“…Endoglin is a type III TGFβ auxiliary receptor that is upregulated in endothelial cells during angiogenesis and, when mutated in humans, results in the…”
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BMP9 regulates endoglin-dependent chemokine responses in endothelial cells by Young, Kira, Conley, Barbara, Romero, Diana, Tweedie, Eric, O'Neill, Christine, Pinz, Ilka, Brogan, Louise, Lindner, Volkhard, Liaw, Lucy, Vary, Calvin P.H.

“…BMP9 signaling has been implicated in hereditary hemorrhagic telangiectasia (HHT) and vascular remodeling, acting via the HHT target genes, endoglin and ALK1…”
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Purification of functional mouse skeletal muscle mitochondria using percoll density gradient centrifugation by Anunciado-Koza, Rea Victoria P, Guntur, Anyonya R, Vary, Calvin P, Gartner, Carlos A, Nowak, Madeleine, Koza, Robert A

“…Our goal was to isolate purified mitochondria from mouse skeletal muscle using a Percoll density gradient and to assess bioenergetic function and purity via…”
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AHNAK2 Participates in the Stress-Induced Nonclassical FGF1 Secretion Pathway by Kirov, Aleksandr, Kacer, Doreen, Conley, Barbara A., Vary, Calvin P.H., Prudovsky, Igor

“…ABSTRACT FGF1 is a nonclassically released growth factor that regulates carcinogenesis, angiogenesis, and inflammation. In vitro and in vivo, FGF1 export is…”
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Understanding Mechanisms Underlying Non-Alcoholic Fatty Liver Disease (NAFLD) in Mental Illness: Risperidone and Olanzapine Alter the Hepatic Proteomic Signature in Mice by Rostama, Bahman, Beauchemin, Megan, Bouchard, Celeste, Bernier, Elizabeth, Vary, Calvin P H, May, Meghan, Houseknecht, Karen L

“…Patients with severe mental illness have increased mortality, often linked to cardio-metabolic disease. Non-alcoholic fatty liver disease (NAFLD) incidence is…”
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RhoA-Mediated Signaling in Notch-Induced Senescence-Like Growth Arrest and Endothelial Barrier Dysfunction by Venkatesh, Deepak, Fredette, Natalie, Rostama, Bahman, Tang, Yuefeng, Vary, Calvin P.H, Liaw, Lucy, Urs, Sumithra

“…OBJECTIVE—Notch signaling has a critical role in vascular development and morphogenesis. Activation of Notch in endothelial cells led to a senescence-like…”
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Improved Survival Outcomes in Cancer Patients with Hereditary Hemorrhagic Telangiectasia by DUARTE, Christine W, MURRAY, Kimberly, LUCAS, F. Lee, FAIRFIELD, Kathleen, MILLER, Heather, BROOKS, Peter, VARY, Calvin P. H

“…Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder characterized by deficiency in endoglin, an angiogenic protein. The net effect of endoglin…”
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Endoglin-mediated suppression of prostate cancer invasion is regulated by activin and bone morphogenetic protein type II receptors by Breen, Michael J, Moran, Diarmuid M, Liu, Wenzhe, Huang, Xiaoke, Vary, Calvin P H, Bergan, Raymond C

“…Mortality from prostate cancer (PCa) is due to the formation of metastatic disease. Understanding how that process is regulated is therefore critical. We…”
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Endoglin Regulates Cancer-Stromal Cell Interactions in Prostate Tumors by ROMERO, Diana, O'NEILL, Christine, TERZIC, Aleksandra, CONTOIS, Liangru, YOUNG, Kira, CONLEY, Barbara A, BERGAN, Raymond C, BROOKS, Peter C, VARY, Calvin P. H

“…Endoglin is an accessory receptor for TGF-β that has been implicated in prostate cancer cell detachment, migration, and invasiveness. However, the…”
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Cancer incidence in patients with hereditary hemorrhagic telangiectasia by Duarte, Christine W., Black, Adam W., Lucas, F. Lee, Vary, Calvin P. H.

“…Purpose Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder characterized by deficiency in endoglin, an angiogenic protein. We previously showed…”
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Endoglin suppresses human prostate cancer metastasis by Lakshman, Minalini, Huang, Xiaoke, Ananthanarayanan, Vijayalakshmi, Jovanovic, Borko, Liu, Yueqin, Craft, Clarissa S, Romero, Diana, Vary, Calvin P. H, Bergan, Raymond C

“…Endoglin is a transmembrane receptor that suppresses human prostate cancer (PCa) cell invasion. Small molecule therapeutics now being tested in humans can…”
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Mechanisms of TGF-β-induced differentiation in human vascular smooth muscle cells by Tang, Yuefeng, Yang, Xuehui, Friesel, Robert E, Vary, Calvin P H, Liaw, Lucy

“…Transforming growth factor-β (TGF-β) plays an important role in vascular homeostasis through effects on vascular smooth muscle cells (SMC). Fine-tuning of…”
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Increases in serum estrogen levels during major illness are caused by increased peripheral aromatization by Spratt, Daniel I, Morton, Jeremy R, Kramer, Robert S, Mayo, Sara W, Longcope, Christopher, Vary, Calvin P H

“…Although serum testosterone levels decrease acutely in critically ill patients, estrogen levels rise. We hypothesized that increased rates of aromatization of…”
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Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration by Romero, Diana, Terzic, Aleksandra, Conley, Barbara A., Craft, Clarissa S., Jovanovic, Borko, Bergan, Raymond C., Vary, Calvin P.H.

“…Endoglin, a transmembrane glycoprotein that acts as a transforming growth factor-β (TGF-β) coreceptor, is downregulated in PC3-M metastatic prostate cancer…”
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The TGF-β co-receptor endoglin modulates the expression and transforming potential of H-Ras by Santibanez, Juan F., Pérez-Gómez, Eduardo, Fernandez-L, Africa, Garrido-Martin, Eva M., Carnero, Amancio, Malumbres, Marcos, Vary, Calvin P.H., Quintanilla, Miguel, Bernabéu, Carmelo

“…Endoglin is a coreceptor for transforming growth factor-β (TGF-β) that acts as a suppressor of malignancy during mouse skin carcinogenesis. Because in this…”
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Functional blockade of Smad4 leads to a decrease in β-catenin levels and signaling activity in human pancreatic carcinoma cells by Romero, Diana, Iglesias, Maite, Vary, Calvin P.H., Quintanilla, Miguel

“…In the last several years, many laboratories have tried to unravel the complex signaling mechanisms activated by TGF-β1 in transformed cells. Smad proteins are…”
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Transcriptional activation of endoglin and transforming growth factor-β signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury by Botella, Luisa M., Sánchez-Elsner, Tilman, Sanz-Rodriguez, Francisco, Kojima, Soichi, Shimada, Jun, Guerrero-Esteo, Mercedes, Cooreman, Michael P., Ratziu, Vlad, Langa, Carmen, Vary, CalvinP.H., Ramı́rez, Jose R., Friedman, Scott, Bernabéu, Carmelo

“…Endoglin is an endothelial membrane glycoprotein involved in cardiovascular morphogenesis and vascular remodeling. It associates with transforming growth…”
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Genistein induces phenotypic reversion of endoglin deficiency in human prostate cancer cells by Craft, Clarissa S, Xu, Li, Romero, Diana, Vary, Calvin P H, Bergan, Raymond C

“…Genistein has been shown to inhibit human prostate cancer (PCa) cell motility. Endoglin has been identified as an important suppressor of PCa cell motility,…”
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Endoglin Regulates Cyclooxygenase-2 Expression and Activity by Jerkic, Mirjana, Rivas-Elena, Juan V, Santibanez, Juan F, Prieto, Marta, Rodríguez-Barbero, Alicia, Perez-Barriocanal, Fernando, Pericacho, Miguel, Arévalo, Miguel, Vary, Calvin P.H, Letarte, Michelle, Bernabeu, Carmelo, López-Novoa, Jose M

“…The endoglin heterozygous (Eng) mouse, which serves as a model of hereditary hemorrhagic telangiectasia (HHT), was shown to express reduced levels of…”
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