Search Results - "Varughese, Kottayil I"

In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration by Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Ayyadevara, Haarika, Kiaei, Lily, Shmookler Reis, Robert J., Varughese, Kottayil I., Kiaei, Mahmoud

“…Amyotrophic lateral sclerosis (ALS) is an inexorably progressive and degenerative disorder of motor neurons with no currently-known cure. Studies to determine…”
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Structure-based Design Targeted at LOX-1, a Receptor for Oxidized Low-Density Lipoprotein by Thakkar, Shraddha, Wang, Xianwei, Khaidakov, Magomed, Dai, Yao, Gokulan, Kuppan, Mehta, Jawahar L., Varughese, Kottayil I.

“…Atherosclerosis related cardiovascular diseases continue to be the primary cause of mortality in developed countries. The elevated level of low density…”
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LOX-1 in Atherosclerosis and Myocardial Ischemia by Pothineni, Naga Venkata K., MD, Karathanasis, Sotirios K., PhD, Ding, Zufeng, PhD, Arulandu, Arockiasamy, PhD, Varughese, Kottayil I., PhD, Mehta, Jawahar L., MD, PhD

“…Abstract Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), one of the scavenger receptors for oxidized low-density lipoprotein cholesterol…”
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LIS1 Regulates Osteoclastogenesis through Modulation of M-SCF and RANKL Signaling Pathways and CDC42 by Ye, Shiqiao, Fujiwara, Toshifumi, Zhou, Jian, Varughese, Kottayil I, Zhao, Haibo

“…We have previously reported that depletion of LIS1, a key regulator of microtubules and cytoplasmic dynein motor complex, in osteoclast precursor cells by…”
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Structural characterization of a therapeutic anti-methamphetamine antibody fragment: oligomerization and binding of active metabolites by Peterson, Eric C, Celikel, Reha, Gokulan, Kuppan, Varughese, Kottayil I

“…Vaccines and monoclonal antibodies (mAb) for treatment of (+)-methamphetamine (METH) abuse are in late stage preclinical and early clinical trial phases,…”
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The Crystal Structure of Beryllofluoride Spo0F in Complex with the Phosphotransferase Spo0B Represents a Phosphotransfer Pretransition State by VARUGHESE, Kottayil I, TSIGELNY, Igor, HAIYAN ZHAO

“…AUTHOR'S CORRECTION ( vol. 189 , p. 3328 ) Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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Correction: Structural Characterization of a Therapeutic Anti-Methamphetamine Antibody Fragment: Oligomerization and Binding of Active Metabolites by Peterson, Eric C., Celikel, Reha, Gokulan, Kuppan, Varughese, Kottayil I.

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LOX-1 in Atherosclerosis and Myocardial Ischemia: Biology, Genetics, and Modulation by Pothineni, Naga Venkata K, Karathanasis, Sotirios K, Ding, Zufeng, Arulandu, Arockiasamy, Varughese, Kottayil I, Mehta, Jawahar L

“…Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), one of the scavenger receptors for oxidized low-density lipoprotein cholesterol (ox-LDL),…”
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Crystal structure of the transcriptional repressor PagR of Bacillus anthracis by Zhao, Haiyan, Volkov, Arsen, Veldore, Vidya Harini, Hoch, James A, Varughese, Kottayil I

“…1 Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA 2 Department of Physiology and Biophysics,…”
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A transient interaction between two phosphorelay proteins trapped in a crystal lattice reveals the mechanism of molecular recognition and phosphotransfer in signal transduction by Zapf, James, Sen, Udayaditya, Madhusudan, Hoch, James A, Varughese, Kottayil I

“…Background: Spo0F and Spo0B specifically exchange a phosphoryl group in a central step of the phosphorelay signal transduction system that controls sporulation…”
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Oxidized LDL receptors: a recent update by Khan, Mohd Azeem, Mohammad, Irshad, Banerjee, Sohom, Tomar, Akanksha, Varughese, Kottayil I, Mehta, Jawahar L, Chandele, Anmol, Arockiasamy, Arulandu

“…LDL in its oxidized form, or 'oxLDL', is now generally acknowledged to be highly proatherogenic and to play a significant role in atherosclerotic plaque…”
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PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis by Fujiwara, Toshifumi, Ye, Shiqiao, Castro-Gomes, Thiago, Winchell, Caylin G., Andrews, Norma W., Voth, Daniel E., Varughese, Kottayil I., Mackintosh, Samuel G., Feng, Yunfeng, Pavlos, Nathan, Nakamura, Takashi, Manolagas, Stavros C., Zhao, Haibo

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(E)-13-(4-Amino-phen-yl)parthenolide by Penthala, Narsimha Reddy, Janganati, Venumadhav, Parkin, Sean, Varughese, Kottayil I, Crooks, Peter A

“…The title compound, C21H25NO3 [systematic name:…”
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Exploring the druggability of oxidized low-density lipoprotein (ox-LDL) receptor, LOX-1, a proatherogenic drug target involved in atherosclerosis by Tomar, Akanksha, Sahoo, Sibasis, Aathi, Muthusankar, Kuila, Shobhan, Khan, Mohd Azeem, Ravi, Guru Raj Rao, Jeyaraman, Jeyakanthan, Mehta, Jawahar L., Varughese, Kottayil I., Arockiasamy, Arulandu

“…Lectin-like oxidized low-density lipoprotein (ox-LDL) receptor 1 (LOX-1) is a vital scavenger receptor involved in ox-LDL binding, internalization, and…”
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Drug resistance in Mycobacterium tuberculosis and targeting the l,d‐transpeptidase enzyme by Gokulan, Kuppan, Varughese, Kottayil I.

“…Tuberculosis (TB) is a disease that has afflicted mankind for thousands of years, but in the last seven decades, much progress has been made in anti‐TB…”
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Conformational Changes of Spo0F along the Phosphotransfer Pathway by VARUGHESE, Kottayil I, WEMMER, David E, KERN, Dorothee

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The structural basis of effective LOX-1 inhibition by Kore, Rajshekhar A, Bagchi, Ashim K, Varughese, Kottayil I, Mehta, Jawahar L

“…Along with other scavenger receptors, splice variants of LOX-1 play an important role in modulating numerous subcellular mechanisms such as normal cell…”
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ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation by Kiaei, Mahmoud, Balasubramaniam, Meenakshisundaram, Govind Kumar, Vivek, Shmookler Reis, Robert J., Moradi, Mahmoud, Varughese, Kottayil I.

“…Profilin-1 (PFN1) is a 140-amino-acid protein with two distinct binding sites―one for actin and one for poly-L-proline (PLP). The best-described function of…”
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Structure and Inhibitor Specificity of L,D-Transpeptidase (LdtMt2) from Mycobacterium tuberculosis and Antibiotic Resistance: Calcium Binding Promotes Dimer Formation by Gokulan, Kuppan, Khare, Sangeeta, Cerniglia, Carl E., Foley, Steven L., Varughese, Kottayil I.

“…The final step of peptidoglycan (PG) synthesis in all bacteria is the formation of cross-linkage between PG-stems. The cross-linking between amino acids in…”
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The crystal structure of YycH involved in the regulation of the essential YycFG two‐component system in Bacillus subtilis reveals a novel tertiary structure by Szurmant, Hendrik, Zhao, Haiyan, Mohan, Michael A., Hoch, James A., Varughese, Kottayil I.

“…The Bacillus subtilis YycFG two‐component signal transduction system is essential for cell viability, and the YycH protein is part of the regulatory circuit…”
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