Search Results - "Vartanov, Alexander R"

SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia by Wang, Lili, Lawrence, Michael S, Wan, Youzhong, Stojanov, Petar, Sougnez, Carrie, Stevenson, Kristen, Werner, Lillian, Sivachenko, Andrey, DeLuca, David S, Zhang, Li, Zhang, Wandi, Vartanov, Alexander R, Fernandes, Stacey M, Goldstein, Natalie R, Folco, Eric G, Cibulskis, Kristian, Tesar, Bethany, Sievers, Quinlan L, Shefler, Erica, Gabriel, Stacey, Hacohen, Nir, Reed, Robin, Meyerson, Matthew, Golub, Todd R, Lander, Eric S, Neuberg, Donna, Brown, Jennifer R, Getz, Gad, Wu, Catherine J

“…CLL is a heterogeneous disease with a variable clinical course and response to therapy. New genetic lesions have been noted in subgroups of patients through…”
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Concurrent Lymphoma and COVID-19: Diagnostic and Therapeutic Challenges of High-Grade Lymphoma and COVID-19 by Hundal, Jasmin, Vartanov, Alexander R, Huh, Kang, Ballesteros, Enrique, Forbes, Victoria

“…The coronavirus disease 2019 (COVID-19) global pandemic has put an unprecedented strain on cancer care. The initial months were marred by fears of…”
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Association of advanced leukemic stage and skin cancer tumor stage with poor skin cancer outcomes in patients with chronic lymphocytic leukemia by Velez, Nicole F, Karia, Pritesh S, Vartanov, Alexander R, Davids, Matthew S, Brown, Jennifer R, Schmults, Chrysalyne D

“…Although it has been well established that patients with chronic lymphocytic leukemia (CLL) have an increased risk of developing skin cancer, few studies have…”
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Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL by Wang, Lili, Shalek, Alex K., Lawrence, Mike, Ding, Ruihua, Gaublomme, Jellert T., Pochet, Nathalie, Stojanov, Petar, Sougnez, Carrie, Shukla, Sachet A., Stevenson, Kristen E., Zhang, Wandi, Wong, Jessica, Sievers, Quinlan L., MacDonald, Bryan T., Vartanov, Alexander R., Goldstein, Natalie R., Neuberg, Donna, He, Xi, Lander, Eric, Hacohen, Nir, Regev, Aviv, Getz, Gad, Brown, Jennifer R., Park, Hongkun, Wu, Catherine J.

“…One major goal of cancer genome sequencing is to identify key genes and pathways that drive tumor pathogenesis. Although many studies have identified candidate…”
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Ofatumumab plus high dose methylprednisolone followed by ofatumumab plus alemtuzumab to achieve maximal cytoreduction prior to allogeneic transplantation for 17p deleted or TP53 mutated chronic lymphocytic leukemia by Davids, Matthew S., Kim, Haesook T., Yu, Lijian, De Maeyer, Guadalupe, McDonough, Mikaela, Vartanov, Alexander R., Langey, Rachael, Fernandes, Stacey M., Hellman, Jeffrey M., Francoeur, Karen, Arnason, Jon, Jacobsen, Eric D., LaCasce, Ann S., Fisher, David C., Brown, Jennifer R.

“…We hypothesized that ofatumumab with sequential methylprednisolone - alemtuzumab would be an effective and tolerable regimen for patients with high-risk…”
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A Comparative Analysis of Engraftment Outcomes for Recipients of Allogeneic Hematopoietic Stem Cell Transplants (allo HSCT) and Post-Transplant Cyclophosphamide (PTCy) Based on Ideal Body Weight (IBW) or Actual Body Weight (ABW) Dosing of CD34-Positive Stem Cells by Styler, Michael, Shestovska, Yuliya, Vartanov, Alexander R, Varshavsky-Yanovsky, Asya, Khanal, Rashmi, Abdelmessieh, Peter, Joshi, Shalina, Mandzhieva, Dzhirgala, Fung, Henry

“…Previous studies have demonstrated that CD34+ cell doses using IBW are more predictive of engraftment than ABW, with 2 × 106 CD34 cells/Kg of IBW established…”
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Mass Cytometry Identifies T Cell Populations Associated with Severe Hepatotoxicity in CLL Patients on Upfront Idelalisib by Vartanov, Alexander R., Matos, Tiago R, McWilliams, Emily M., Gadi, Deepti, Rao, Deepak, Kasar, Siddha, Lampson, Benjamin L., Fernandes, Stacey M., Ritz, Jerome, Brown, Jennifer R.

“…Introduction Phosphatidylinositol-3-kinase (PI3K) inhibition has emerged as a novel targeted mechanism for achieving durable remission in CLL in both the…”
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High Sensitivity NGS Analysis of MRD in CLL Patients Prospectively Treated with Ibrutinib Plus FCR (iFCR) by Vartanov, Alexander R., Fernandes, Stacey M., Nguy, Winnie I, Brander, Danielle M., Tyekucheva, Svitlana, Savell, Alexandra, Jacob, Allison P., Arnason, Jon E., Abramson, Jeremy S., Davids, Matthew S., Brown, Jennifer R.

“…Background Studies from the chemoimmunotherapy (CIT) era and more recently with venetoclax have demonstrated the correlation between minimal residual disease…”
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Imbalance in T Cell Subsets Triggers the Autoimmune Toxicity of PI3K Inhibitors in CLL by Gadi, Deepti, Kasar, Siddha, Griffith, Alec, Chiu, Pui Yan, Tyekucheva, Svitlana, Rai, Vanessa, Vartanov, Alexander R., Fernandes, Stacey M., Pan, Yang, Lederer, James A, Sherry, Barbara, Brown, Jennifer R.

“…Idelalisib and duvelisib are FDA approved oral inhibitors of PI3K delta and PI3K delta/gamma, respectively. Previously, we reported a decrease in regulatory T…”
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Using Oral Vancomycin As Prophylaxis Against Clostridioides Difficile Infection in Stem Cell Transplant Recipients Is Associated with Increased Gram Negative Bacteremia by Vartanov, Alexander R, Shestovska, Yuliya, Hamby, Matthew, Sorrentino, Michele, Ballas, Brittany, Ridgway, Forrest, Mandzhieva, Dzhirgala, Ojala, Anne, Abdelmessieh, Peter, Varshavsky-Yanovsky, Asya, Styler, Michael, Fung, Henry, Khanal, Rashmi

“…Infections complications continue to pose significant risk for patients undergoing hematopoietic stem cell transplantation (HSCT). Clostridioides difficile…”
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High-grade heart block associated with ibrutinib therapy by Vartanov, Alexander R., Lampson, Benjamin L., Jacobsen, Eric D., Alyea, Edwin P., Moslehi, Javid J., Brown, Jennifer R.

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Whole Genome Sequencing of Indolent CLL Reveals Novel Structural Rearrangements by Kasar, Siddha, Tiao, Grace, Improgo, Reina, Kiezun, Adam, Sougnez, Carrie, Bahl, Samira, Fernandes, Stacey M., Vartanov, Alexander R., Hoang, Kevin, Gabriel, Stacey, Landau, Dan A., Wu, Catherine J, Lander, Eric, Kim, Haesook T., Getz, Gad, Brown, Jennifer R.

“…Several recent next generation sequencing studies have uncovered mutations in key genes that contribute to CLL pathogenesis. Most CLLs with deletions of…”
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Rearrangement of 14q32 in the Absence of t(14;18) Is Associated with Short Time to First Treatment in Chronic Lymphocytic Leukemia by Davids, Matthew S., Vartanov, Alexander R., Werner, Lillian, Neuberg, Donna, Cin, Paola Dal, Brown, Jennifer R

“…Abstract 1438 The hierarchical cytogenetic classification for chronic lymphocytic leukemia (CLL) provides a valuable prognostic framework validated in several…”
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Prior Treatment with Chemotherapy Is Associated with Poor Outcomes of High Risk Skin Cancers in Patients with Chronic Lymphocytic Leukemia by Davids, Matthew S., Velez, Nicole F., Karia, Pritesh, Guo, Ye, Vartanov, Alexander R., Neel, Victor A., Brown, Jennifer R., Schmults, Chrysalyne D.

“…Abstract 3920 The increased incidence of skin cancer in patients with chronic lymphocytic leukemia (CLL) has been well-documented; however, the outcomes for…”
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Effect Of MYD88 Mutation In CLL On IRAK4 and BTK Inhibition In Vitro by Tesar, Bethany, Chaudhary, Divya, Werner, Lillian, Improgo, Reina, Pochet, Nathalie, Fernandes, Stacey M, Hoang, Kevin, Vartanov, Alexander R., Romero, Donna L., Robinson, Shaughnessy D., Neuberg, Donna S., Westlin, William F., Brown, Jennifer R.

“…Recent work in CLL and other lymphoproliferative disorders has established the importance of somatic mutations in the pathogenesis and prognosis of disease…”
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NF-κB Pathway Mutations Modulate Cell Survival and Ibrutinib Response In Chronic Lymphocytic Leukemia by Improgo, Reina, Tiao, Grace, Kiezun, Adam, Wang, Yaoyu, Werner, Lillian, Sougnez, Carrie, Tesar, Bethany, Fernandes, Stacey M, Vartanov, Alexander R., Hoang, Kevin, Neuberg, Donna S., Getz, Gad, Brown, Jennifer R.

“…Constitutive activation of the NF-κB pathway is a critical feature of hematologic malignancies and is associated with increased lymphocyte proliferation and…”
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Functional Somatic and Germline Variants in the NF-κB Pathway in Chronic Lymphocytic Leukemia by Improgo, Ma. Reina, Kiezun, Adam, Wang, Yaoyu, Werner, Lillian, Stojanov, Petar, Landau, Dan, Sougnez, Carrie, Tesar, Bethany, Fernandes, Stacey M., Vartanov, Alexander R., Lawrence, Michael S., Cibulskis, Kristian, Neuberg, Donna S., Wu, Catherine J., Getz, Gad, Brown, Jennifer R.

“…Abstract 560 Nuclear factor kappa B (NF-κB) encompasses a family of transcription factors involved in oncogenic processes including cellular proliferation and…”
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Somatic and Germline Copy Neutral Loss of Heterozygosity Are Common in Chronic Lymphocytic Leukemia by Hanna, Megan, Tesar, Bethany, Stevenson, Kristen E., Vartanov, Alexander R., Fernandes, Stacey M., Macconaill, Laura, Landau, Dan-Avi, Wu, Catherine J., Neuberg, Donna S., Freedman, Arnold S., Brown, Jennifer R.

“…Abstract 4567 Chronic lymphocytic leukemia (CLL) is the most common leukemia of adults, and prognosis is still difficult to predict, although cytogenetic…”
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The Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia by Landau, Dan-Avi, Carter, Scott, Stojanov, Petar, Stevenson, Kristen E., Mckenna, Aaron, Lawrence, Michael, Sougnez, Carrie, Sivachenko, Andrey, Wang, Lili, Zhang, Wandi, Sachet, Shukla, Vartanov, Alexander R., Fernandes, Stacey M., Cibulskis, Kristian, Tesar, Bethany, Gabriel, Stacey, Meyerson, Matthew, Lander, Eric S., Neuberg, Donna S., Brown, Jennifer R., Getz, Gad, Wu, Catherine J.

“…Abstract 5 The impact of clonal heterogeneity on cancer progression in chronic lymphocytic leukemia (CLL) is not well understood. We hypothesized that the…”
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Novel Germline Genetic Variants Associated with Familial Chronic Lymphocytic Leukemia (CLL) by Brown, Jennifer R, Lawrence, Michael S, Hanna, Megan, Tesar, Bethany, Stojanov, Petar, Vartanov, Alexander R., Fernandes, Stacey M, Sougnez, Carrie, MacConaill, Laura, Pochet, Nathalie, Regev, Aviv, Werner, Lillian, Gabriel, Stacey, Lander, Eric S, Neuberg, Donna, Freedman, Arnold S., Getz, Gad, Wu, Catherine J

“…Abstract 465 CLL is among the most heritable of all cancers. To understand the genetic basis of this heritability, we have undertaken a comprehensive genomic…”
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