Search Results - "Vartabedian, Vincent F."

Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic by Chin, Emily N, Yu, Chenguang, Vartabedian, Vincent F, Jia, Ying, Kumar, Manoj, Gamo, Ana M, Vernier, William, Ali, Sabrina H, Kissai, Mildred, Lazar, Daniel C, Nguyen, Nhan, Pereira, Laura E, Benish, Brent, Woods, Ashley K, Joseph, Sean B, Chu, Alan, Johnson, Kristen A, Sander, Philipp N, Martínez-Peña, Francisco, Hampton, Eric N, Young, Travis S, Wolan, Dennis W, Chatterjee, Arnab K, Schultz, Peter G, Petrassi, H Michael, Teijaro, John R, Lairson, Luke L

“…Stimulator of interferon genes (STING) links innate immunity to biological processes ranging from antitumor immunity to microbiome homeostasis. Mechanistic…”
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The processing and presentation of lipids and glycolipids to the immune system by Vartabedian, Vincent F., Savage, Paul B., Teyton, Luc

“…Summary The recognition of CD1–lipid complexes by T cells was discovered 20 years ago and has since been an emerging and expanding field of investigation…”
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Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo by Ogasawara, Daisuke, Ichu, Taka-Aki, Vartabedian, Vincent F., Benthuysen, Jacqueline, Jing, Hui, Reed, Alex, Ulanovskaya, Olesya A., Hulce, Jonathan J., Roberts, Amanda, Brown, Steven, Rosen, Hugh, Teijaro, John R., Cravatt, Benjamin F.

“…ABHD12 metabolizes bioactive lysophospholipids, including lysophosphatidylserine (lyso-PS). Deleterious mutations in human ABHD12 cause the neurological…”
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Identification of an N-acetylneuraminic acid-presenting bacteria isolated from a human microbiome by Han, Zhen, Thuy-Boun, Peter S., Pfeiffer, Wayne, Vartabedian, Vincent F., Torkamani, Ali, Teijaro, John R., Wolan, Dennis W.

“…N -Acetylneuraminic acid is the most abundant sialic acid (SA) in humans and is expressed as the terminal sugar on intestinal mucus glycans. Several pathogenic…”
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IFN-β, but not IFN-α, is Responsible for the Pro-Bacterial Effect of Type I Interferon by Shaabani, Namir, Vartabedian, Vincent F, Nguyen, Nhan, Honke, Nadine, Huang, Zhe, Teijaro, John R

“…During an immune response, type I interferon (IFN-I) signaling induces a wide range of changes, including those which are required to overcome viral infection…”
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Endoplasmic Reticulum Proteostasis Influences the Oligomeric State of an Amyloidogenic Protein Secreted from Mammalian Cells by Chen, John J, Genereux, Joseph C, Suh, Eul Hyun, Vartabedian, Vincent F, Rius, Bibiana, Qu, Song, Dendle, Maria T A, Kelly, Jeffery W, Wiseman, R Luke

“…Transthyretin (TTR) is a tetrameric serum protein associated with multiple systemic amyloid diseases. In these disorders, TTR aggregates in extracellular…”
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Sialic Acid Ligands of CD28 Suppress Costimulation of T Cells by Edgar, Landon J, Thompson, Andrew J, Vartabedian, Vincent F, Kikuchi, Chika, Woehl, Jordan L, Teijaro, John R, Paulson, James C

“…Effector T cells comprise the cellular arm of the adaptive immune system and are essential for mounting immune responses against pathogens and cancer. To reach…”
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Tumor membrane-based vaccine immunotherapy in combination with anti-CTLA-4 antibody confers protection against immune checkpoint resistant murine triple-negative breast cancer by Pack, Christopher D., Bommireddy, Ramireddy, Munoz, Luis E., Patel, Jaina M., Bozeman, Erica N., Dey, Paulami, Radhakrishnan, Vijayaraghavan, Vartabedian, Vincent F., Venkat, Kalpana, Ramachandiran, Sampath, Reddy, Shaker J. C., Selvaraj, Periasamy

“…Triple-negative breast cancer (TNBC) afflicts women at a younger age than other breast cancers and is associated with a worse clinical outcome. This poor…”
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IL-27 promotes the expansion of self-renewing CD8 + T cells in persistent viral infection by Huang, Zhe, Zak, Jaroslav, Pratumchai, Isaraphorn, Shaabani, Namir, Vartabedian, Vincent F, Nguyen, Nhan, Wu, Tuoqi, Xiao, Changchun, Teijaro, John R

“…Chronic infection and cancer are associated with suppressed T cell responses in the presence of cognate antigen. Recent work identified memory-like CXCR5 TCF1…”
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ISG15 Drives Immune Pathology and Respiratory Failure during Systemic Lymphocytic Choriomeningitis Virus Infection by Shaabani, Namir, Zak, Jaroslav, Johnson, Jennifer L., Huang, Zhe, Nguyen, Nhan, Lazar, Daniel C., Vartabedian, Vincent F., Honke, Nadine, Jardine, Joseph G., Woehl, Jordan, Prinz, Marco, Knobeloch, Klaus-Peter, Arimoto, Kei-Ichiro, Zhang, Dong-Er, Catz, Sergio D., Teijaro, John R.

“…Abstract ISG15, an IFN-stimulated gene, plays a crucial role in modulating immune responses during viral infections. Its upregulation is part of the host’s…”
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Proteomic discovery of chemical probes that perturb protein complexes in human cells by Lazear, Michael R., Remsberg, Jarrett R., Jaeger, Martin G., Rothamel, Katherine, Her, Hsuan-lin, DeMeester, Kristen E., Njomen, Evert, Hogg, Simon J., Rahman, Jahan, Whitby, Landon R., Won, Sang Joon, Schafroth, Michael A., Ogasawara, Daisuke, Yokoyama, Minoru, Lindsey, Garrett L., Li, Haoxin, Germain, Jason, Barbas, Sabrina, Vaughan, Joan, Hanigan, Thomas W., Vartabedian, Vincent F., Reinhardt, Christopher J., Dix, Melissa M., Koo, Seong Joo, Heo, Inha, Teijaro, John R., Simon, Gabriel M., Ghosh, Brahma, Abdel-Wahab, Omar, Ahn, Kay, Saghatelian, Alan, Melillo, Bruno, Schreiber, Stuart L., Yeo, Gene W., Cravatt, Benjamin F.

“…Most human proteins lack chemical probes, and several large-scale and generalizable small-molecule binding assays have been introduced to address this problem…”
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Influenza virus-like particles engineered by protein transfer with tumor-associated antigens induces protective antitumor immunity by Patel, Jaina M., Vartabedian, Vincent F., Kim, Min-Chul, He, Sara, Kang, Sang-Moo, Selvaraj, Periasamy

“…ABSTRACT Delivery of antigen in particulate form using either synthetic or natural particles induces stronger immunity than soluble forms of the antigen. Among…”
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Plasma membrane vesicles decorated with glycolipid-anchored antigens and adjuvants via protein transfer as an antigen delivery platform for inhibition of tumor growth by Patel, Jaina M, Vartabedian, Vincent F, Bozeman, Erica N, Caoyonan, Brianne E, Srivatsan, Sanjay, Pack, Christopher D, Dey, Paulami, D'Souza, Martin J, Yang, Lily, Selvaraj, Periasamy

“…Abstract Antigen delivered within particulate materials leads to enhanced antigen-specific immunity compared to soluble administration of antigen. However,…”
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Protein transfer-mediated surface engineering to adjuvantate virus-like nanoparticles for enhanced anti-viral immune responses by Patel, Jaina M, Kim, Min-Chul, PhD, Vartabedian, Vincent F, Lee, Yu-Na, PhD, He, Sara, MS, Song, Jae-Min, PhD, Choi, Hyo-Jick, PhD, Yamanaka, Satoshi, Amaram, Nikhil, Lukacher, Anna, Montemagno, Carlo D., PhD, Compans, Richard W., PhD, Kang, Sang-Moo, PhD, Selvaraj, Periasamy, PhD

“…Abstract Recombinant virus-like nanoparticles (VLPs) are a promising nanoparticle platform to develop safe vaccines for many viruses. Herein, we describe a…”
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Cancer CARtography: charting out a new approach to cancer immunotherapy by Patel, Jaina M, Dale, Gordon A, Vartabedian, Vincent F, Dey, Paulami, Selvaraj, Periasamy

“…Evaluation of: Davila ML, Riviere I, Wang X et al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci…”
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Too Much of a Good Thing: IFN-I, Dendritic Cells, and Cancer by Vartabedian, Vincent F, Kemper, Esther K, Parker, Christopher G, Shaabani, Namir, Teijaro, John R

“…Abstract To prime T cells to fight cancer, dendritic cells (DCs) require Type I Interferon (IFN-I) signaling. IFN-I signaling induces the transcription and…”
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Abstract 1735: The potent and selective MERTK/AXL inhibitor PF-5807/ARRY-067 activates dendritic cells to cross-prime CD8+ T cells for anti-tumor activity by Wong, Jim, Harrison, Jacqueline, Bouhana, Karyn, Nguyen, Nhan, Shaabani, Namir, Vartabedian, Vincent F., Cable, LouAnn, Rieger, Robert, Opie, Lisa Pieti, Allen, Shelley, Cook, Adam, Dahlke, Joshua, Hinklin, Ronald, Chantry, David, Winski, Shannon, Teijaro, John

“…Abstract The TAM family of receptor tyrosine kinases (MERTK, AXL, and TYRO3) are expressed on DCs and macrophages, and they serve a critical role in…”
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Modulation of Anti-viral and Anti-tumor Immune Responses through Chemical and Genetic Means by Vartabedian, Vincent F

“…Cancer and viral infections are major global health burdens that affect hundreds of millions of people per year, cause millions of deaths, and exert billions…”
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